Mixed-Methods Study of Multidimensional Adversity in Inner-City African American Adults with Chronic Kidney Disease and Type 2 Diabetes Mellitus
患有慢性肾病和 2 型糖尿病的内城非裔美国成年人多维逆境的混合方法研究
基本信息
- 批准号:10650248
- 负责人:
- 金额:$ 14.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-19 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAdultAfrican AmericanAfrican American populationBehaviorBehavior TherapyBlood PressureChronic Kidney FailureClinicalCommunity Health AidesComplexComplications of Diabetes MellitusDataDevelopmentDiabetic NephropathyDimensionsDisease ManagementDisease ProgressionEffectivenessEmploymentEnd stage renal failureFinancial HardshipGlycosylated hemoglobin AGoalsIndividualInterventionIntervention StudiesInterviewKnowledgeLife StyleLipidsLong-Term EffectsMentored Patient-Oriented Research Career Development AwardMethodsMonitorNon-Insulin-Dependent Diabetes MellitusOutcomePatient EducationPatient-Focused OutcomesPatientsPopulationQuality of lifeRandomized, Controlled TrialsResearch DesignReview LiteratureRiskRoleSafetySamplingSelf CareSelf ManagementTransportationbarrier to carebehavior changecareerdietary adherenceexercise adherenceexperiencefood insecurityhealth disparityhigh riskhousing instabilityimprovedinner cityinnovationintervention mappingmedication compliancepeer supportsocial adversity
项目摘要
PROJECT SUMMARY
Approximately 40% of individuals with type 2 diabetes (T2DM) have chronic kidney disease (CKD), also
known as diabetic kidney disease (DKD). DKD is the leading cause of end stage renal disease (ESRD), and
ESRD is the most expensive complication of diabetes. African American adults are almost twice as likely to
have DKD and are three times more likely to progress to ESRD. Inner-city populations, made up of
predominantly African Americans, are at high risk for DKD. Challenges of living in the inner-city include
multidimensional adversity, defined as having three or more social adversities such as loss of employment,
housing instability, food insecurity, transportation needs, utility needs, interpersonal safety, and financial strain.
African American adults living in the inner-city disproportionately experience multidimensional adversity, which
impacts the complex self-management of DKD such as self-monitoring and behavior modification. The
compounded risks of being African American, living in the inner-city, having T2DM and multidimensional
adversity likely contribute to the accelerated rate of CKD progression among African American adults and
potentiate existing health disparities. Patient education and self-management behaviors improve patient
outcomes and represent the cornerstone of DKD management. In addition, behavioral intervention studies in
African American adults with T2DM incorporating cultural tailoring, peer-support/coaching, and community
health workers have shown promise in improving short-term clinical outcomes. However, their benefits are not
sustained long-term, and they do not produce long-term effects on lifestyle and behavior changes. Further,
majority of existing studies do not account for the unique challenges of inner-city African American adults
which limits effectiveness of patient education and self-management behaviors in African American adults
living in the inner-city long-term. Similarly, studies in African American adults with T2DM and CKD that
incorporate the challenges of living with multidimensional adversity are scarce, despite growing evidence which
recognizes the negative effects of multidimensional adversity on clinical outcomes in this population.
Therefore, the goal of this proposal is to address these gaps in knowledge using a convergent parallel mixed
methods study design to understand the role and effect of multidimensional adversity in African American
adults with DKD. In addition, this proposal will identify appropriate intervention components which will inform
the development of a culturally tailored intervention that addresses multidimensional adversity to improve
clinical outcomes, quality of life, and self-care behaviors in African American adults with DKD living in the
inner-city. Ultimately, findings from this proposal will serve as a preliminary data for addressing
multidimensional adversity in a large-scale appropriately powered, multicenter, randomized controlled trial
focused on African American adults with DKD.
项目摘要
大约40%的2型糖尿病(T2 DM)患者患有慢性肾病(CKD),
糖尿病肾病(DKD)。DKD是终末期肾病(ESRD)的主要原因,
ESRD是糖尿病最昂贵的并发症。非洲裔美国成年人几乎是
患有DKD,并且进展为ESRD的可能性增加三倍。市中心的人口,
主要是非洲裔美国人,是DKD的高风险人群。生活在市中心的挑战包括
多维逆境,定义为有三个或三个以上的社会逆境,如失业,
住房不稳定、粮食不安全、交通需求、公用事业需求、人际安全和财政紧张。
生活在市中心的非洲裔美国成年人不成比例地经历多方面的逆境,
影响DKD复杂的自我管理,如自我监测和行为矫正。的
非洲裔美国人,生活在市中心,患有T2 DM和多方面的风险
逆境可能导致非裔美国成年人CKD进展速度加快,
加剧现有的健康差距。患者教育和自我管理行为改善患者
结果,并代表DKD管理的基石。此外,行为干预研究,
非裔美国成年T2 DM患者纳入文化定制、同伴支持/指导和社区
卫生工作者在改善短期临床结果方面显示出希望。然而,它们的好处不是
长期持续,它们不会对生活方式和行为改变产生长期影响。此外,本发明还
大多数现有的研究没有考虑到市中心非裔美国成年人的独特挑战
这限制了非裔美国成年人的患者教育和自我管理行为的有效性
长期居住在市中心。同样,在患有T2 DM和CKD的非裔美国成年人中进行的研究,
尽管越来越多的证据表明,
认识到多维逆境对这一人群临床结局的负面影响。
因此,本提案的目标是使用一种趋同的并行混合
方法研究设计,以了解非洲裔美国人的多维度逆境的作用和影响,
成人DKD此外,该提案将确定适当的干预内容,
制定针对文化的干预措施,解决多层面的逆境,以改善
生活在美国的非裔美国成年DKD患者的临床结局、生活质量和自我护理行为
市中心最终,该提案的调查结果将作为解决以下问题的初步数据:
一项大规模、适当把握度、多中心、随机对照试验中的多维逆境
重点关注患有DKD的非裔美国成年人。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Mukoso N Ozieh其他文献
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{{ truncateString('Mukoso N Ozieh', 18)}}的其他基金
Mixed-Methods Study of Multidimensional Adversity in Inner-City African American Adults with Chronic Kidney Disease and Type 2 Diabetes Mellitus
患有慢性肾病和 2 型糖尿病的内城非裔美国成年人多维逆境的混合方法研究
- 批准号:
10448678 - 财政年份:2022
- 资助金额:
$ 14.92万 - 项目类别:
Basic Needs Navigation Intervention to Address Multidimensional Adversity in African Americans with Diabetic Kidney Disease
基本需求导航干预,以解决患有糖尿病肾病的非裔美国人的多维逆境
- 批准号:
10352781 - 财政年份:2021
- 资助金额:
$ 14.92万 - 项目类别:
Basic Needs Navigation Intervention to Address Multidimensional Adversity in African Americans with Diabetic Kidney Disease
基本需求导航干预,以解决患有糖尿病肾病的非裔美国人的多维逆境
- 批准号:
10676228 - 财政年份:2021
- 资助金额:
$ 14.92万 - 项目类别:
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