Spatial and temporal tumor-immune co-evolution and interactions that model lung adenocarcinoma development
模拟肺腺癌发展的时空肿瘤免疫协同进化和相互作用
基本信息
- 批准号:10651836
- 负责人:
- 金额:$ 42.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAtlasesB cell clonalityB-Cell Antigen ReceptorB-LymphocytesCell CommunicationCell modelCellsCessation of lifeClinicalCommunitiesComplexCopy Number PolymorphismDataDevelopmentDiagnosisDimensionsDiseaseDisease OutcomeDistantEarly DiagnosisEarly treatmentEcosystemEpitheliumEventEvolutionExhibitsFoundationsHeterogeneityHumanImmuneImmunologic ReceptorsImmunotherapyIndividualInflammatoryKnowledgeLesionLungLung AdenocarcinomaMalignant - descriptorMalignant NeoplasmsMalignant neoplasm of lungMapsModelingMolecularMusMutationMutation AnalysisNormal CellNormal tissue morphologyPathogenesisPathologicPathologic ProcessesPatientsPerformancePhenotypePhysiological ProcessesPopulationPrevention strategyProbabilityPrognosisPropertyRNAReceptor CellRecurrenceRoleSiteSmokingSomatic MutationStructure of parenchyma of lungTechnologyTestingTimeTrainingWorkcohortdata portalimmunological interventionimprovedin vivolung developmentlung lesionmachine learning modelmathematical modelmouse modelneoplasticnovel therapeutic interventionpatient subsetspremalignantprogenitorprogramssingle cell sequencingsingle cell technologyspatiotemporaltranscriptome sequencingtranscriptomicstreatment strategytumortumor heterogeneitytumor-immune system interactions
项目摘要
PROJECT SUMMARY
Lung adenocarcinoma (LUAD) is the most frequent subtype of lung cancer and accounts for most cancer
deaths. Improved early detection has increased the number of LUADs diagnosed at earlier pathological stages,
thus warranting strategies to treat this growing patient subpopulation. Thwarting these advances is a very poor
understanding of early events that drive LUAD development and that thus would guide ideal approaches for
interception. While normal lung epithelia of LUAD patients were shown to display tumor-pertinent molecular
and inflammatory changes, it is not clear why a LUAD develops within a particular region in the lung. Whereas
the lung is ecologically rich with many cell populations that partake in both physiological and pathological
processes, we still do not know how the properties and roles of individual cell populations, such as epithelial
and immune subsets, co-evolve and interact to instigate LUAD development from a specific niche in the lung.
In our preliminary efforts, we found by multi-region single-cell sequencing remarkable evolution of the
properties and transcriptomic features of multiple cell subsets and states (e.g., protumor immunosuppressive
phenotypes) across macro-space, such that cellular ecosystems and immune cell receptor repertoires were
more similar among LUADs and adjacent normal regions than with more distant normal sites. Also, such
spatial properties were progressively enriched along the pathologic continuum of matched human normal lung,
to preneoplasias, up to invasive LUADs. Our preliminary findings motivate the hypothesis that geospatially
and temporally evolving expression programs, properties, and interplay of epithelial and immune cells
model early development of LUAD from the normal and premalignant lung. In Aim 1, we will study LUADs
and matched multi-region normal tissues with defined spatial proximities from the tumors by single-cell RNA
and immune receptor sequencing in conjunction with analysis of mutations in the tumors to establish single-cell
maps of LUAD and immune co-evolution in space. Spatially modulated cell properties and states will then be
used to feed and train a machine learning model that portrays LUAD development from the lung ecosystem. In
Aim 2, we will single-cell decode tumor-immune co-evolution along the pathologic continuum of normal and
premalignant lung to LUAD as well as identify cell states and properties that are modulated by early immune
intervention. We will use temporal information in mice, along with human matched normal lung tissues,
preneoplastic lesions, and invasive LUADs, to iteratively validate and fine-tune the performance of our machine
learning model to portray LUAD development in time from the normal and premalignant lung. At the end of our
studies, we will have built new models that reliably portray LUAD evolution in space and time. By providing an
atlas of LUAD development in an accessible data portal, we also expect that our study will offer scalable
roadmaps for the scientific community to develop new strategies for treatment of this fatal disease.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cell-by-Cell: Unlocking Lung Cancer Pathogenesis.
- DOI:10.3390/cancers14143424
- 发表时间:2022-07-14
- 期刊:
- 影响因子:5.2
- 作者:
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Humam Kadara其他文献
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{{ truncateString('Humam Kadara', 18)}}的其他基金
Spatial and temporal tumor-immune co-evolution and interactions that model lung adenocarcinoma development
模拟肺腺癌发展的时空肿瘤免疫协同进化和相互作用
- 批准号:
10447468 - 财政年份:2022
- 资助金额:
$ 42.87万 - 项目类别:
Interplay between host microbiome and immunomodulatory responses in the pathogenesis of Kras mutant lung cancer
Kras 突变肺癌发病机制中宿主微生物组与免疫调节反应之间的相互作用
- 批准号:
10555291 - 财政年份:2021
- 资助金额:
$ 42.87万 - 项目类别:
Interplay between host microbiome and immunomodulatory responses in the pathogenesis of Kras mutant lung cancer
Kras 突变肺癌发病机制中宿主微生物组与免疫调节反应之间的相互作用
- 批准号:
10186622 - 财政年份:2021
- 资助金额:
$ 42.87万 - 项目类别:
Interplay between host microbiome and immunomodulatory responses in the pathogenesis of Kras mutant lung cancer
Kras 突变肺癌发病机制中宿主微生物组与免疫调节反应之间的相互作用
- 批准号:
10356940 - 财政年份:2021
- 资助金额:
$ 42.87万 - 项目类别:
(PQ1) Progression of the airway field of injury to Kras mutant lung cancer
(PQ1) Kras 突变肺癌气道损伤的进展
- 批准号:
9171783 - 财政年份:2016
- 资助金额:
$ 42.87万 - 项目类别:
(PQ1) Progression of the airway field of injury to Kras mutant lung cancer
(PQ1) Kras 突变肺癌气道损伤的进展
- 批准号:
9355580 - 财政年份:2016
- 资助金额:
$ 42.87万 - 项目类别:
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