Instrumenting the Fetal Membrane on a Chip

在芯片上检测胎儿膜

基本信息

  • 批准号:
    10651647
  • 负责人:
  • 金额:
    $ 61.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-01 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

The first time the immune system can respond to a pathogen is in utero during infections of the fetal membrane. Infection involving the fetal membranes is extremely difficult to study in utero, both because of inaccessibility and the nature of the complicated interface between mother and child. Thus, studies of pregnancy-related conditions benefit from an in vitro model of the fetal membrane, i.e., a highly instrumented fetal membrane on a chip (IFMOC). Specifically, the overarching goal of this research project is to apply multidimensional analytical technologies and microfluidics engineering design to define immune response biosignatures of infection in the in vitro fetal membrane. Given these signatures, our ultimate long-range goal for this bench-to-bedside research program is to develop a simple, inexpensive, and robust lab-on-a-chip system that will permit accurate etiologic diagnosis of infections early during the course of illness based on systemic host-response signatures of infection. We will also utilize sensitive and specific methodologies to differentiate acute infections from pre-existing chronic infections and/or asymptomatic microbial colonization. This work will be based on a fundamental understanding of the human systems biology of infectious diseases and will benefit from recent advances in organ-on-chip microfluidics, optical, amperometric, and enzymatic sensors, and mass spectrometry. Our initial multianalyte sensor profiles are focused on cellular bioenergetics using glucose consumption and lactate production and oxidative burst by superoxide production measured by our microfabricated amperometric sensors as well as MIC-1 protein secretion by the quartz crystal microbalance; subsequently these signatures will be expanded with ion mobility-mass spectrometry (IM-MS).
免疫系统第一次对病原体作出反应是在子宫内感染期间

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Trace Oxygen Affects Osmium Redox Polymer Synthesis for Wired Enzymatic Biosensors.
微量氧气影响有线酶生物传感器的锇氧化还原聚合物合成。
  • DOI:
    10.1149/1945-7111/ac42a0
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    Calhoun,MargaretC;Stachurski,ChristopherD;Winn,SaraL;Gizzie,EvanA;Daniel,AaronW;Schley,NathanD;Cliffel,DavidE
  • 通讯作者:
    Cliffel,DavidE
Chlorpyrifos Disrupts Acetylcholine Metabolism Across Model Blood-Brain Barrier.
Insights and prospects for ion mobility-mass spectrometry in clinical chemistry.
  • DOI:
    10.1080/14789450.2022.2026218
  • 发表时间:
    2022-01
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
    Koomen DC;May JC;McLean JA
  • 通讯作者:
    McLean JA
Adsorption and Electropolymerization of p-Aminophenol Reduces Reproducibility of Electrochemical Immunoassays.
  • DOI:
    10.3390/molecules27186046
  • 发表时间:
    2022-09-16
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Buckey G;Owens OE;Gabriel AW;Downing CM;Calhoun MC;Cliffel DE
  • 通讯作者:
    Cliffel DE
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DAVID E CLIFFEL其他文献

DAVID E CLIFFEL的其他文献

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{{ truncateString('DAVID E CLIFFEL', 18)}}的其他基金

Potentiating Psilocybin
增强裸盖菇素
  • 批准号:
    10354547
  • 财政年份:
    2022
  • 资助金额:
    $ 61.85万
  • 项目类别:
Potentiating Psilocybin
增强裸盖菇素
  • 批准号:
    10602394
  • 财政年份:
    2022
  • 资助金额:
    $ 61.85万
  • 项目类别:
Instrumenting the Fetal Membrane on a Chip
在芯片上检测胎儿膜
  • 批准号:
    10037372
  • 财政年份:
    2020
  • 资助金额:
    $ 61.85万
  • 项目类别:
Instrumenting the Fetal Membrane on a Chip
在芯片上检测胎儿膜
  • 批准号:
    10430227
  • 财政年份:
    2020
  • 资助金额:
    $ 61.85万
  • 项目类别:
Instrumenting the Fetal Membrane on a Chip
在芯片上检测胎儿膜
  • 批准号:
    10249282
  • 财政年份:
    2020
  • 资助金额:
    $ 61.85万
  • 项目类别:
The Fisk-Vanderbilt Biomedical Bridge to the Doctorate
菲斯克-范德比尔特生物医学博士桥梁
  • 批准号:
    8575127
  • 财政年份:
    2013
  • 资助金额:
    $ 61.85万
  • 项目类别:
The Fisk-Vanderbilt Biomedical Bridge to the Doctorate
菲斯克-范德比尔特生物医学博士桥梁
  • 批准号:
    8734456
  • 财政年份:
    2013
  • 资助金额:
    $ 61.85万
  • 项目类别:
The Fisk-Vanderbilt Biomedical Bridge to the Doctorate
菲斯克-范德比尔特生物医学博士桥梁
  • 批准号:
    8883627
  • 财政年份:
    2013
  • 资助金额:
    $ 61.85万
  • 项目类别:
The Fisk-Vanderbilt Biomedical Bridge to the Doctorate
菲斯克-范德比尔特生物医学博士桥梁
  • 批准号:
    9274302
  • 财政年份:
    2013
  • 资助金额:
    $ 61.85万
  • 项目类别:
Epitope Discovery via Nanocluster Presentation
通过纳米簇展示发现表位
  • 批准号:
    7783751
  • 财政年份:
    2006
  • 资助金额:
    $ 61.85万
  • 项目类别:

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