成人高血压患者的睡眠质量和心血管风险机制-猫眼课题宝

成人高血压患者的睡眠质量和心血管风险机制

批准号：

10651685

负责人：

ANDREW SHERWOOD

金额：

$74.09万

依托单位：

DUKE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2019

资助国家：

美国

项目状态：

已结题

起止时间：

2019-07-01 至 2024-06-30

来源：

https://reporter.nih.gov/project-details/10651685

关键词：

Address Adult Ambulatory Blood Pressure Monitoring Antihypertensive Agents Behavior Therapy Biological Assay Blood Blood Pressure Cardiovascular Diseases Catecholamines Characteristics Chronic Insomnia Cognitive Therapy Comorbid Insomnia Dose Event Excretory function Exhibits Fasting Hour Hypertension Inferior Intervention Interview Link Lipids Measures Mediating Meta-Analysis Morbidity - disease rate Myocardial Infarction Myocardial Ischemia Outcome Study Participant Patient Self-Report Patients Pharmaceutical Preparations Physiologic pulse Prevalence Reporting Research Design Risk Factors Risk Reduction Running Serum Sleep Sleep Disorders Sleeplessness Stroke Structure Sympathetic Nervous System Technology Vascular Endothelium Woman Wrist actigraphy arterial stiffness biobehavior brachial artery candidate identification cardiovascular disorder risk cardiovascular risk factor circadian design falls follow-up improved improvement on sleep men mortality multimodality poor sleep risk prediction sleep quality treatment response urinary

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中文摘要

翻译

R 01项目概要高血压患者睡眠质量与心血管风险的关系这项研究的目的是阐明心血管疾病风险增加的潜在机制高血压合并失眠症的患者中。为了解决这个问题，我们建议使用对150名高血压伴失眠症的成年人进行行为干预，将接受为期6周的认知行为治疗（CBT-I）干预，该干预已被证明显著改善睡眠质量，促进约60%的患者巩固睡眠。钝夜间血压下降是几种有待研究的机制之一。

英文摘要

R01 Brief Project Summary Sleep Quality and Mechanisms of Cardiovascular Risk in Adults with Hypertension The objective of the study is to elucidate the potential mechanisms responsible for the increased risk of CVD among patients with hypertension and comorbid insomnia. To address this issue, we propose to utilize a behavioral intervention to manipulate sleep quality in 150 adults with hypertension and comorbid insomnia, who will receive a 6-week Cognitive Behavioral Therapy for Insomnia (CBT-I) intervention, which has been shown to markedly improve sleep quality and promote consolidated sleep in approximately 60% of those treated. Blunted nighttime blood pressure dipping is one of several proposed mechanisms to be examined.

期刊论文(1)

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会议论文

Cognitive behavior therapy for insomnia for untreated hypertension with comorbid insomnia disorder: The SLEEPRIGHT clinical trial.

针对未治疗的高血压合并失眠症的失眠症的认知行为疗法：SLEEPRIGHT 临床试验。

DOI： 10.1111/jch.14763

发表时间： 2024

期刊：

Journal of clinical hypertension (Greenwich, Conn.)

影响因子： --

作者：

[Sherwood,Andrew, Ulmer,Christi, Wu,JadeQ, Blumenthal,JamesA, Herold,Emma, Smith,PatrickJ, Koch,GaryG, Johnson,Kristy, Viera,Anthony, Edinger,Jack, Hinderliter,Alan]

通讯作者： Hinderliter,Alan