Development and Testing of LUCID: A Therapeutic Device for Brain Injury Following Infant Cardiac Arrest

LUCID 的开发和测试:婴儿心脏骤停后脑损伤的治疗装置

基本信息

  • 批准号:
    10515831
  • 负责人:
  • 金额:
    $ 99.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-21 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Cardiac arrest in infants is a medical emergency requiring rapid resuscitation to restore circulation. However, resuscitation often results in significant brain injury, caused by ischemia/reperfusion injury. Only 36% of infants (<1yr old) treated for out-of-hospital cardiac arrest and 69% of infants that suffer in-hospital cardiac arrest are successfully resuscitated. These infants currently have no therapeutic options to limit brain injury. The current standard treatment for post-cardiac arrest brain injury is therapeutic hypothermia. Unfortunately, recent studies demonstrated that use of therapeutic hypothermia in pediatric cardiac arrest patients does not provide significant benefit beyond what is achieved with controlled normothermia. A safe and effective neuroprotective intervention that specifically targets reperfusion injury would fill a critical unmet need in the treatment of these vulnerable patients. Our molecular studies on mitochondria uncovered a novel method to non-invasively modulate mitochondrial function during reperfusion and reduce brain injury following resuscitation from cardiac arrest. Indeed, our studies have, for the first time: (i) identified two wavelengths of near infrared light (NIR) that specifically and reversibly reduce mitochondrial respiration by acting on cytochrome c oxidase (COX); (ii) documented that NIR, applied at the time of reoxygenation, is neuroprotective in rodent and swine models of infant and pediatric cardiac arrest/resuscitation; and (iii) developed a NIR-delivery system capable of providing therapeutic doses to patients up to 1 year old. Based on these data, we propose to produce the clinical Light Utilizing COX- Inhibitory Device (LUCID), a medical device that will safely deliver therapeutic NIR to the infant brain. To achieve this goal, Phase I will focus on device development and validation of LUCID in 3 experimental aims: • Develop LUCID engineered for clinical use (Aim 1). • Evaluate safety and efficacy of LUCID (Aim 2). • LUCID clinical trial development and HUD and IDE approval (Aim 3). Phase II will utilize the LUCID clinical device and execute the “LUCID Therapy for Infant Cardiac Arrest” (LUTICA) clinical trial (Aim 4). This proposal combines multi-disciplinary expertise, compelling preliminary data, and state-of-the-art resources available to our team to address a significant health problem in a highly vulnerable patient population.
婴儿心脏骤停是一种医学紧急情况,需要快速复苏以恢复血液循环。然而,

项目成果

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MAIK HUETTEMANN其他文献

MAIK HUETTEMANN的其他文献

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{{ truncateString('MAIK HUETTEMANN', 18)}}的其他基金

Development and Testing of LUCID: A Therapeutic Device for Brain Injury Following Infant Cardiac Arrest
LUCID 的开发和测试:婴儿心脏骤停后脑损伤的治疗装置
  • 批准号:
    10708811
  • 财政年份:
    2022
  • 资助金额:
    $ 99.93万
  • 项目类别:
Non-invasive mitochondrial modulation therapy for ischemic stroke
缺血性中风的非侵入性线粒体调节疗法
  • 批准号:
    10352458
  • 财政年份:
    2021
  • 资助金额:
    $ 99.93万
  • 项目类别:
Non-invasive mitochondrial modulation therapy for ischemic stroke
缺血性中风的非侵入性线粒体调节疗法
  • 批准号:
    10231915
  • 财政年份:
    2021
  • 资助金额:
    $ 99.93万
  • 项目类别:
Non-invasive mitochondrial modulation therapy for ischemic stroke
缺血性中风的非侵入性线粒体调节疗法
  • 批准号:
    10583532
  • 财政年份:
    2021
  • 资助金额:
    $ 99.93万
  • 项目类别:
Infant NeuroLUX: A Novel Non-invasive Therapeutic Device for Neonatal Hypoxic Brain Injury
Infant NeuroLUX:一种治疗新生儿缺氧性脑损伤的新型非侵入性治疗装置
  • 批准号:
    10001121
  • 财政年份:
    2019
  • 资助金额:
    $ 99.93万
  • 项目类别:
Infant NeuroLUX: A Novel Non-invasive Therapeutic Device for Neonatal Hypoxic Brain Injury
Infant NeuroLUX:一种治疗新生儿缺氧性脑损伤的新型非侵入性治疗装置
  • 批准号:
    10017347
  • 财政年份:
    2019
  • 资助金额:
    $ 99.93万
  • 项目类别:
Control of Cell Respiration and Apoptosis by Phosphorylation of Cytochrome c
通过细胞色素 c 磷酸化控制细胞呼吸和凋亡
  • 批准号:
    9982332
  • 财政年份:
    2017
  • 资助金额:
    $ 99.93万
  • 项目类别:
Control of Cell Respiration and Apoptosis by Phosphorylation of Cytochrome c
通过细胞色素 c 磷酸化控制细胞呼吸和凋亡
  • 批准号:
    9236889
  • 财政年份:
    2017
  • 资助金额:
    $ 99.93万
  • 项目类别:
Limiting brain reperfusion injury by controlling mitochondrial function
通过控制线粒体功能限制脑再灌注损伤
  • 批准号:
    9149032
  • 财政年份:
    2015
  • 资助金额:
    $ 99.93万
  • 项目类别:
Regulation of Respiration and Apoptosis by Cytochrome c Phosphorylation.
细胞色素 c 磷酸化对呼吸和细胞凋亡的调节。
  • 批准号:
    8306157
  • 财政年份:
    2010
  • 资助金额:
    $ 99.93万
  • 项目类别:

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