The Effects of a Cognitive Behavioral Healthy Lifestyle Intervention for Cardiovascular Risk Reduction in Posttraumatic Stress Disorder

认知行为健康生活方式干预对降低创伤后应激障碍心血管风险的影响

• 批准号: 10515042
• 负责人: Jeffrey L. Kibler
• 金额: $ 43.02万
• 依托单位: NOVA SOUTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10515042
• 关键词: Accelerometer; Address; Adult; Age; Area; Arousal; Behavior; Behavior Therapy; Behavioral; Blood Pressure; Body Weight; Body mass index; Cardiovascular Diseases; Cardiovascular system; Cholesterol; Clinic; Clinical Sciences; Cognitive; Consumption; Disease Marker; Endothelium; Evaluation; Gender; General Population; Goals; Health behavior; High Density Lipoprotein Cholesterol; Individual; Intervention; LDL Cholesterol Lipoproteins; Life; Lipids; Measures; National Heart, Lung, and Blood Institute; Nightmare; Outcome; Participant; Pattern; Physical activity; Physiological; Population; Populations at Risk; Post-Traumatic Stress Disorders; Psychotherapy; Randomized; Recommendation; Research; Research Priority; Rest; Risk Reduction; Sleep; Sleep disturbances; Stress; Symptoms; Testing; Time; Triglycerides; Veterans; arterial stiffness; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; cognitive benefits; design; effective intervention; experimental study; follow-up; fruits and vegetables; healthy lifestyle; heart disease risk; heart rate variability; improved; indexing; lifestyle intervention; longitudinal design; medical specialties; member; nutrition; perceived stress; post intervention; post-traumatic stress; response; sleep quality; stress management; symptomatic improvement; treatment as usual; working group

Project Summary. Considerable research has indicated strong associations between posttraumatic stress and cardiovascular disease (CVD) risk. Individuals with posttraumatic stress disorder (PTSD) tend to show patterns of elevated CVD risk earlier in life than in the general population. The need for developing effective interventions for CVD risk-reduction in PTSD is increasingly evident. In comparison to the cumulative evidence concerning elevated CVD risk in PTSD, relatively little research has addressed CVD risk- reduction in this population. Adjunctive treatments, such as health behavior interventions, may be necessary as supplements to traditional psychotherapy for PTSD in order to reduce CVD risks. The objective of the proposed project is to examine the effects of a healthy lifestyle intervention that addresses multiple CVD-related heath behaviors among civilian adults across genders (ages 18+), who evidence PTSD and CVD risk at baseline. We will assess the intervention impact on both subjective and objective indices of health behaviors, cardiovascular risks and CVD markers over a one-year timeframe. The healthy lifestyle intervention addresses unique aspects of PTSD symptom presentation that serve as barriers to healthy behaviors (e.g., avoidance of physiological arousal/activation, viewing extra body weight as protection against abuse, nightmares/sleep disruption, and cognitive responses to stress), while encouraging healthy lifestyle changes. The primary goal of the present study is to examine whether, compared to a usual care psychotherapy control condition, utilizing the healthy lifestyle intervention as an adjunct to psychotherapy will result in significantly reduced CVD risks and improved CVD markers among civilian adults with PTSD and elevated CVD risks. Therefore, participants will be randomly assigned to either a usual care psychotherapy-only control condition or a usual care psychotherapy plus healthy lifestyle intervention condition. Outcomes will be assessed at post-intervention (12 weeks), as well as 6- month and 12-month time points for follow-up evaluation.

项目摘要。 大量研究表明，创伤后应激与心血管疾病之间存在密切联系。 疾病（CVD）风险。患有创伤后应激障碍（PTSD）的人往往表现出以下模式： 在生命早期CVD风险升高比一般人群。发展有效的 降低PTSD患者心血管疾病风险的干预措施越来越明显。与累计相比， 关于PTSD中CVD风险升高的证据，相对较少的研究涉及CVD风险- 减少这一人口。辅助治疗，如健康行为干预，可能是 作为传统PTSD心理治疗的补充，以减少CVD风险。 拟议项目的目的是研究健康生活方式干预的效果， 解决了不同性别（18岁以上）平民成年人中多种CVD相关的健康行为， PTSD和CVD风险的证据。我们将评估干预对主观和 健康行为、心血管风险和心血管疾病标志物的客观指数。 健康的生活方式干预解决了PTSD症状表现的独特方面， 健康行为的障碍（例如，避免生理唤醒/激活，查看额外的身体 体重作为防止虐待、噩梦/睡眠中断和对压力的认知反应的保护），而 鼓励健康生活方式的改变。本研究的主要目的是探讨， 与通常的护理心理治疗对照条件相比，利用健康生活方式干预作为 心理治疗的辅助治疗将显著降低心血管疾病的风险，并改善心血管疾病的标志物， 患有创伤后应激障碍和心血管疾病风险升高的成年平民因此，参与者将被随机分配到 无论是常规护理心理治疗，只有控制条件或常规护理心理治疗加健康 生活方式干预条件。将在干预后（12周）以及6- 随访评价的时间点为1个月和12个月。

项目成果

Pilot Findings Indicate a Cognitive Behavioral Healthy Lifestyle Intervention for PTSD Improves Sleep and Physical Activity.

• DOI: 10.3390/brainsci13111565
• 发表时间: 2023-11-08
• 期刊: Brain sciences
• 影响因子: 3.3