Mentoring patient-oriented researchers in inflammatory airway disease

指导炎症性气道疾病领域以患者为中心的研究人员

基本信息

  • 批准号:
    10515489
  • 负责人:
  • 金额:
    $ 19.37万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-01 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

Abstract The overall goal of the proposed research is to identify novel aspects of human innate lymphoid cell (ILC) biology in airway diseases using patient-oriented research (POR) and through mentoring junior clinical investigators. The candidate has a strong record of mentoring individuals at many levels including clinical investigators in multiple specialties. The mentoring plan includes recruitment and training of fellow and faculty investigators from three disciplines (allergy, otolaryngology, and pulmonary) within the UCSD Center for Asthma and Sinus Disease center of excellence to foster the careers of junior investigators and perform outstanding POR. There are currently large gaps in our understanding of the roles of ILCs in human sinus disease and asthma which cause significant morbidity worldwide. ILCs are divided by the types of cytokines they secrete and ILC2s that secrete Th2 cytokines have been shown to promote airway inflammation in animal models. Importantly, recent work has shown that ILC2s are increased in samples from patients with asthma and chronic rhinosinusitis (CRS). Our group was the first to show that ILC2s are increased in a subgroup of nasal polyps in CRS that contain eosinophils and are also recruited to the nose after aspirin challenge in patients with aspirin-exacerbated respiratory disease (AERD). AERD patients have severe sinus disease with nasal polyps, moderate to severe asthma, and respiratory reactions to aspirin and similar compounds. In the current proposal, we will test the hypothesis that through the use of cutting-edge technology (single cell RNA-seq) we will be able to identify specific subgroups or “endotypes” of patients with CRS and asthma by tissue and blood ILC subset composition. We also posit that biologic blockade of type 2 inflammation in AERD, asthma and CRS patients will reduce ILC2 recruitment to the airway. Critically, this award will provide protected time for POR in sinus disease and asthma and allow for outstanding mentorship of the next generations of POR investigators.
摘要

项目成果

期刊论文数量(0)
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TAYLOR A DOHERTY其他文献

TAYLOR A DOHERTY的其他文献

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{{ truncateString('TAYLOR A DOHERTY', 18)}}的其他基金

Mentoring patient-oriented researchers in inflammatory airway disease
指导炎症性气道疾病领域以患者为中心的研究人员
  • 批准号:
    10657746
  • 财政年份:
    2022
  • 资助金额:
    $ 19.37万
  • 项目类别:
Roles of STING and innate lymphoid cell plasticity in severe asthma
STING 和先天淋巴细胞可塑性在严重哮喘中的作用
  • 批准号:
    10514569
  • 财政年份:
    2020
  • 资助金额:
    $ 19.37万
  • 项目类别:
Roles of STING and innate lymphoid cell plasticity in severe asthma
STING 和先天淋巴细胞可塑性在严重哮喘中的作用
  • 批准号:
    10293537
  • 财政年份:
    2020
  • 资助金额:
    $ 19.37万
  • 项目类别:
Roles of STING and innate lymphoid cell plasticity in severe asthma
STING 和先天淋巴细胞可塑性在严重哮喘中的作用
  • 批准号:
    10008266
  • 财政年份:
    2020
  • 资助金额:
    $ 19.37万
  • 项目类别:
RBM3 regulation of type 2 innate lymphoid cells in allergic inflammation
RBM3 对过敏性炎症中 2 型先天淋巴细胞的调节
  • 批准号:
    8799448
  • 财政年份:
    2014
  • 资助金额:
    $ 19.37万
  • 项目类别:
OX40/OX40L interactions in allergen-induced airway inflammation and remodeling
OX40/OX40L 在过敏原诱导的气道炎症和重塑中的相互作用
  • 批准号:
    8305053
  • 财政年份:
    2010
  • 资助金额:
    $ 19.37万
  • 项目类别:
OX40/OX40L interactions in allergen-induced airway inflammation and remodeling
OX40/OX40L 在过敏原诱导的气道炎症和重塑中的相互作用
  • 批准号:
    8129569
  • 财政年份:
    2010
  • 资助金额:
    $ 19.37万
  • 项目类别:
OX40/OX40L interactions in allergen-induced airway inflammation and remodeling
OX40/OX40L 在过敏原诱导的气道炎症和重塑中的相互作用
  • 批准号:
    8704272
  • 财政年份:
    2010
  • 资助金额:
    $ 19.37万
  • 项目类别:
OX40/OX40L interactions in allergen-induced airway inflammation and remodeling
OX40/OX40L 在过敏原诱导的气道炎症和重塑中的相互作用
  • 批准号:
    8502607
  • 财政年份:
    2010
  • 资助金额:
    $ 19.37万
  • 项目类别:
OX40/OX40L interactions in allergen-induced airway inflammation and remodeling
OX40/OX40L 在过敏原诱导的气道炎症和重塑中的相互作用
  • 批准号:
    7989358
  • 财政年份:
    2010
  • 资助金额:
    $ 19.37万
  • 项目类别:

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