Stephenson Cancer Center - Cancer Center Support Grant

史蒂芬森癌症中心 - 癌症中心支持补助金

• 批准号: 10514691
• 负责人: ROBERT S. MANNEL
• 金额: $ 39.99万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10514691
• 关键词: Address; American Indians; Benchmarking; Biometry; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Catchment Area; Clinical; Clinical Data; Clinical Protocols; Clinical Trials; Cytometry; Data; Development; Diagnosis; Direct Costs; Disease; Education; Enrollment; Environment; Environment Design; Foundations; Funding; Goals; Health Professional; Health Technology; Incidence; Intervention; Leadership; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Medical Research; Mission; Molecular Biology; Monitor; NCI-Designated Cancer Center; Nature; Newly Diagnosed; Oklahoma; Oncology; Pathology; Patient-Focused Outcomes; Patients; Peer Review; Physicians; Population; Prevention; Privatization; Protocols documentation; Reporting; Research; Research Design; Research Personnel; Research Training; Resource Sharing; Rural; Safety; Science; Secure; Services; Source; Statutes and Laws; Structure; Tissues; Training; Universities; base; cancer education; cancer health disparity; cancer prevention; cancer research center director; career; data management; high standard; mHealth; member; mortality; multidisciplinary; next generation; organizational structure; pre-clinical; programs; recruit; standard of care; translational cancer research; treatment research; treatment trial; underserved area

OVERALL – ABSTRACT Oklahoma currently ranks 7th highest among all states for cancer mortality rates, and 2nd in cancer incidence and mortality rates among the 15 states currently without an NCI-designated cancer center. To address this cancer burden, the State passed bipartisan-supported legislation in 2001, directing the University of Oklahoma to create an academic cancer center that would provide statewide leadership in cancer education, prevention, treatment and research. Acting on this mandate, the University established the Stephenson Cancer Center (SCC), a matrix-based academic cancer center with a mission of reducing the burden of cancer in Oklahoma, a catchment area underserved by NCI-designated cancer centers. An essential partner in advancing this mission is the Oklahoma Medical Research Foundation (OMRF), the SCC's proposed consortium partner. Under the leadership of Robert Mannel, MD, who was appointed Director in 2006, the SCC has secured institutional and other commitments totaling $383.7 million of state, university and philanthropic dollars over the past ten years, which have been used to recruit new cancer researchers and oncology physicians, add new physical space, and develop formal research programs and new shared resources. The level of support for the SCC constitutes the largest public – private biomedical initiative ever launched in the State and has resulted in an academic cancer center that has achieved the following benchmarks during the reporting period (CY2016):  $18,371,115 in overall funding base (peer-reviewed, cancer-relevant) (direct costs).  $8,981,794 in NCI research and training funding (direct costs).  $34,234,985 in total funding (direct costs).  96 full and associate members, representing 32 different academic departments.  278,609 sf. of total physical space (research, clinical, administrative).  $33.1 million in annual discretionary funds under the control of the SCC Director.  2,727 newly diagnosed and treated patients, with 612 enrollments on interventional treatment trials. The SCC has developed an organizational structure and environment designed to promote transdisciplinary, team-based science, move ideas along the translational continuum and stimulate research that impacts the SCC catchment area. This structure includes three formal research programs: Preclinical Translational Cancer Research (PTCR), Gynecologic Cancers (GC) and Cancer Prevention and Control (CPC). SCC member research is supported by four formal shared resource facilities: Biostatistics and Research Design, Molecular Biology and Cytometry Research, Tissue Pathology and Mobile Health Technology. Centralized Clinical Protocol and Data Management, Data and Safety Monitoring, and Protocol Review and Monitoring functions oversee and support the SCC's robust clinical trials program.

总体--摘要 俄克拉荷马州目前的癌症死亡率在所有州中排名第七，癌症发病率排名第二。 以及目前没有NCI指定癌症中心的15个州的死亡率。要解决这个问题 癌症负担，该州在2001年通过了两党支持的立法，指导俄克拉荷马大学 创建一个学术癌症中心，在全州范围内提供癌症教育、预防、 治疗和研究。根据这一授权，该大学成立了斯蒂芬森癌症中心 (SCC)是一个以矩阵为基础的学术癌症中心，其使命是减轻俄克拉荷马州的癌症负担。 NCI指定的癌症中心服务不足的集水区。推进这一使命的重要合作伙伴 是俄克拉荷马医学研究基金会(OMRF)，SCC拟议的财团合作伙伴。 在2006年被任命为董事的罗伯特·曼内尔医学博士的领导下，SCC获得了 机构和其他承诺，总计3.837亿美元的州、大学和慈善资金 过去十年，一直被用来招聘新的癌症研究人员和肿瘤医生，增加了新的 物理空间，并制定正式的研究计划和新的共享资源。的支持率 SCC是该州有史以来发起的最大的公私生物医学倡议，并已导致 一个学术癌症中心在本报告所述期间(2016财年)实现了以下基准： 总筹资基数为18,371,115美元(同行评审，与癌症相关)(直接成本)。 ：8,981,794美元，用于国家创新中心的研究和培训资金(直接成本)。 资金总额为34,234,985美元(直接成本)。 96个正式成员和准成员，代表32个不同的学术部门。 278,609 SF.占总物理空间的比例(研究、临床、行政)。 在SCC董事控制下的3,310万美元年度可自由支配资金。 新诊断和治疗患者2,727人，有612人参加了介入治疗试验。 SCC建立了一个组织结构和环境，旨在促进跨学科、 基于团队的科学，沿着翻译连续体推动思想，并刺激影响 SCC集水区。这一结构包括三个正式的研究计划：临床前转化性癌症 研究(PTCR)、妇科癌症(GC)和癌症预防与控制(CPC)。SCC成员 研究得到四个正式的共享资源设施的支持：生物统计和研究设计、分子 生物学和细胞学研究、组织病理学和移动卫生技术。集中临床 协议和数据管理、数据和安全监控以及协议审查和监控功能 监督和支持SCC强大的临床试验计划。