Alcohol action on extended amygdala glutamate synapses
Alcohol action on extended amygdala glutamate synapses
批准号:
10515868
负责人:
DANNY G WINDER
金额:
$3.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
未结题
起止时间:
2010-04-01 至 2025-07-31
关键词:
AbstinenceAffectiveAlcohol withdrawal syndromeAlcoholsAmygdaloid structureCellsChronicCommunicationCorticotropin-Releasing Hormone ReceptorsDevelopmentElectrophysiology (science)Financial HardshipGlutamatesHealthInsula of ReilLiteratureManuscriptsMapsMediatingMentorshipModelingN-Methyl-D-Aspartate ReceptorsNeuronsPlayPreparationRegulationResearchRewardsRodentSeriesSocietiesStressSynapsesTestingTrainingalcohol exposurealcohol use disorderbehavioral responsebrain circuitrycareer developmentex vivo imagingexperienceexperimental studynew therapeutic targetposterspostsynapticreceptor functionrecruitskillssymposiumtherapeutic development
中文摘要
摘要
酒精使用障碍(AUD)是我们社会的巨大健康和经济负担。越来越多的文献
表明,扩展杏仁核在压力-奖励相互作用中起着关键作用,
慢性酒精暴露的行为反应我们证明了慢性间歇性酒精暴露
上调CRF受体依赖的谷氨酸释放增加,以及突触后NMDA
受体功能的延伸杏仁核谷氨酸突触。我们建议在这里测试一个“两击”模型,
由此,慢性酒精暴露和戒断所产生的情感障碍取决于
延伸的杏仁核谷氨酸突触的协调的突触前和突触后调节。加强这一
根据受训者的研究经验和发展,我们提出了一系列的实验来绘制机制
通过这种方式,可以通过改变
兴奋性和抑制性驱动。她将在一个强迫禁欲模型中探索这些机制
慢性酒精暴露,获得体外成像和电生理训练,
啮齿动物酒精暴露模型。导师制还将侧重于通过手稿的沟通技巧
为科学会议编写和制作海报。
英文摘要
Abstract
Alcohol Use Disorder (AUD) is a tremendous health and financial burden on our society. A growing literature
indicates that the extended amygdala plays a key role in stress-reward interactions that may mediate key
behavioral responses to chronic alcohol exposure. We demonstrated that chronic intermittent alcohol exposure
up regulates CRF receptor dependent augmentation of glutamate release, as well as postsynaptic NMDA
receptor function at extended amygdala glutamate synapses. We propose here to test a "two-hit" model,
whereby affective disruptions produced by chronic alcohol exposure and withdrawal depend upon the
coordinated pre- and postsynaptic regulation of extended amygdala glutamate synapses. To enhance this
trainee’s research experience and development, we propose a series of experiments to map out mechanisms
by which glutamateric inputs to the BNST (from the insula) may be organized and recruited via changes in
excitatory and inhibitory drive on these cells. She will explore these mechanisms in a forced abstinence model
of chronic alcohol exposure, gaining ex vivo imaging and electrophysiological training, and experience with
rodent alcohol exposure models. Mentorship will also focus on communication skills through manuscript
preparation and preparation of posters for scientific conferences.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Noradrenergic Regulation in the BNST
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批准号:9920688
-
项目类别:
-
资助金额:$35.27万
-
财政年份:2016
-
负责人:DANNY G WINDER
-
依托单位:
Noradrenergic Regulation in the BNST
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批准号:10472646
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项目类别:
-
资助金额:$40.71万
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财政年份:2016
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负责人:DANNY G WINDER
-
依托单位:
Noradrenergic Regulation in the BNST
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批准号:9180250
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项目类别:
-
资助金额:$35.29万
-
财政年份:2016
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负责人:DANNY G WINDER
-
依托单位:
Noradrenergic Regulation in the BNST
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批准号:9917488
-
项目类别:
-
资助金额:$4.14万
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财政年份:2016
-
负责人:DANNY G WINDER
-
依托单位:
Noradrenergic Regulation in the BNST
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批准号:9308915
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项目类别:
-
资助金额:$35.28万
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财政年份:2016
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负责人:DANNY G WINDER
-
依托单位:
Noradrenergic Regulation in the BNST
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批准号:10667494
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项目类别:
-
资助金额:$40.71万
-
财政年份:2016
-
负责人:DANNY G WINDER
-
依托单位:
Noradrenergic Regulation in the BNST
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批准号:10313263
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项目类别:
-
资助金额:$40.71万
-
财政年份:2016
-
负责人:DANNY G WINDER
-
依托单位:
BNST GluN2B and CRF signaling in the antidepressant actions of ketamine
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批准号:8717064
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项目类别:
-
资助金额:$19.59万
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财政年份:2014
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负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10670471
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项目类别:
-
资助金额:$6.65万
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财政年份:2010
-
负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8658782
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项目类别:
-
资助金额:$34.54万
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财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10685339
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项目类别:
-
资助金额:$35.75万
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财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10455751
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项目类别:
-
资助金额:$35.75万
-
财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10886286
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项目类别:
-
资助金额:$3.32万
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财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8005919
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项目类别:
-
资助金额:$36.81万
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财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10242233
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项目类别:
-
资助金额:$35.75万
-
财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8980056
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项目类别:
-
资助金额:$35.29万
-
财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8265728
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项目类别:
-
资助金额:$35.61万
-
财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8097576
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项目类别:
-
资助金额:$35.61万
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财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8459612
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项目类别:
-
资助金额:$33.12万
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财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10209217
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项目类别:
-
资助金额:$35.75万
-
财政年份:2010
-
负责人:DANNY G WINDER
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依托单位:
海外基金