Alcohol action on extended amygdala glutamate synapses
Alcohol action on extended amygdala glutamate synapses
批准号:
10515868
负责人:
DANNY G WINDER
金额:
$3.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
未结题
起止时间:
2010-04-01 至 2025-07-31
关键词:
AbstinenceAffectiveAlcohol withdrawal syndromeAlcoholsAmygdaloid structureCellsChronicCommunicationCorticotropin-Releasing Hormone ReceptorsDevelopmentElectrophysiology (science)Financial HardshipGlutamatesHealthInsula of ReilLiteratureManuscriptsMapsMediatingMentorshipModelingN-Methyl-D-Aspartate ReceptorsNeuronsPlayPreparationRegulationResearchRewardsRodentSeriesSocietiesStressSynapsesTestingTrainingalcohol exposurealcohol use disorderbehavioral responsebrain circuitrycareer developmentex vivo imagingexperienceexperimental studynew therapeutic targetposterspostsynapticreceptor functionrecruitskillssymposiumtherapeutic development
中文摘要
摘要
酒精使用障碍 (AUD) 给我们的社会带来了巨大的健康和经济负担。不断增长的文学
表明扩展的杏仁核在压力-奖励相互作用中发挥着关键作用,可能调解关键
对长期酒精暴露的行为反应。我们证明,慢性间歇性酒精暴露
上调 CRF 受体依赖性谷氨酸释放增强以及突触后 NMDA
扩展杏仁核谷氨酸突触的受体功能。我们在这里建议测试“两次打击”模型,
长期接触酒精和戒断造成的情感破坏取决于
扩展杏仁核谷氨酸突触的突触前和突触后协调调节。为了增强这一点
根据受训者的研究经验和发展,我们提出了一系列实验来制定机制
通过这种方式,可以通过改变来组织和招募 BNST(来自岛)的谷氨酸输入
对这些细胞的兴奋性和抑制性驱动。她将在强制禁欲模型中探索这些机制
慢性酒精暴露,获得离体成像和电生理训练,以及经验
啮齿动物酒精暴露模型。指导还将侧重于通过手稿进行沟通技巧
科学会议海报的准备和制作。
英文摘要
Abstract
Alcohol Use Disorder (AUD) is a tremendous health and financial burden on our society. A growing literature
indicates that the extended amygdala plays a key role in stress-reward interactions that may mediate key
behavioral responses to chronic alcohol exposure. We demonstrated that chronic intermittent alcohol exposure
up regulates CRF receptor dependent augmentation of glutamate release, as well as postsynaptic NMDA
receptor function at extended amygdala glutamate synapses. We propose here to test a "two-hit" model,
whereby affective disruptions produced by chronic alcohol exposure and withdrawal depend upon the
coordinated pre- and postsynaptic regulation of extended amygdala glutamate synapses. To enhance this
trainee’s research experience and development, we propose a series of experiments to map out mechanisms
by which glutamateric inputs to the BNST (from the insula) may be organized and recruited via changes in
excitatory and inhibitory drive on these cells. She will explore these mechanisms in a forced abstinence model
of chronic alcohol exposure, gaining ex vivo imaging and electrophysiological training, and experience with
rodent alcohol exposure models. Mentorship will also focus on communication skills through manuscript
preparation and preparation of posters for scientific conferences.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Noradrenergic Regulation in the BNST
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批准号:9920688
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项目类别:
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资助金额:$35.27万
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财政年份:2016
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负责人:DANNY G WINDER
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依托单位:
Noradrenergic Regulation in the BNST
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批准号:10472646
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项目类别:
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资助金额:$40.71万
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财政年份:2016
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负责人:DANNY G WINDER
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依托单位:
Noradrenergic Regulation in the BNST
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批准号:9180250
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项目类别:
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资助金额:$35.29万
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财政年份:2016
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负责人:DANNY G WINDER
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依托单位:
Noradrenergic Regulation in the BNST
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批准号:9917488
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项目类别:
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资助金额:$4.14万
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财政年份:2016
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负责人:DANNY G WINDER
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依托单位:
Noradrenergic Regulation in the BNST
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批准号:9308915
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项目类别:
-
资助金额:$35.28万
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财政年份:2016
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负责人:DANNY G WINDER
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依托单位:
Noradrenergic Regulation in the BNST
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批准号:10313263
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项目类别:
-
资助金额:$40.71万
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财政年份:2016
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负责人:DANNY G WINDER
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依托单位:
Noradrenergic Regulation in the BNST
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批准号:10667494
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项目类别:
-
资助金额:$40.71万
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财政年份:2016
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负责人:DANNY G WINDER
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依托单位:
BNST GluN2B and CRF signaling in the antidepressant actions of ketamine
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批准号:8717064
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项目类别:
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资助金额:$19.59万
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财政年份:2014
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负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10670471
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项目类别:
-
资助金额:$6.65万
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财政年份:2010
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负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8658782
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项目类别:
-
资助金额:$34.54万
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财政年份:2010
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负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10685339
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项目类别:
-
资助金额:$35.75万
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财政年份:2010
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负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10455751
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项目类别:
-
资助金额:$35.75万
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财政年份:2010
-
负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10886286
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项目类别:
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资助金额:$3.32万
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财政年份:2010
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负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8005919
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项目类别:
-
资助金额:$36.81万
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财政年份:2010
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负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:10242233
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项目类别:
-
资助金额:$35.75万
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财政年份:2010
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负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8980056
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项目类别:
-
资助金额:$35.29万
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财政年份:2010
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负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8265728
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项目类别:
-
资助金额:$35.61万
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财政年份:2010
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负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8097576
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项目类别:
-
资助金额:$35.61万
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财政年份:2010
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负责人:DANNY G WINDER
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依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:8459612
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项目类别:
-
资助金额:$33.12万
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财政年份:2010
-
负责人:DANNY G WINDER
-
依托单位:
Alcohol action on extended amygdala glutamate synapses
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批准号:9754571
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项目类别:
-
资助金额:$46.5万
-
财政年份:2010
-
负责人:DANNY G WINDER
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依托单位:
海外基金