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Beyond ganglion cells: Novel foveal avascular zone features in MS with implications for vision loss

超越神经节细胞：多发性硬化症中新的中心凹无血管区特征对视力丧失的影响

基本信息

批准号：
10522605
负责人：
Heather Elspeth Moss
金额：
$ 52.77万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-30 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10522605
关键词：
Address Adult Affect Age Atrophic Autopsy Behavior Biological Biological Markers Blindness Brain Caring Cessation of life Clinic Clinical Clinical Research Comparative Study Complement Confocal Microscopy Coupled Detection Diagnosis Disease Disease Progression Elderly Electroretinography Etiology Experimental Models Eye Functional disorder Future Glaucoma Glean High Prevalence Human Image Imaging Device Imaging Techniques Immunofluorescence Immunologic In Vitro Inflammatory Investigation Lesion Light Location Longitudinal Studies Measurement Measures Methods Microscopy Minority Groups Monitor Multiple Sclerosis Nature Nerve Degeneration Neurodegenerative Disorders Neurologic Ophthalmoscopy Optic Nerve Pathologic Pathology Patients Persons Phenotype Photoreceptors Physicians Population Productivity Protocols documentation Quality of life Research Research Personnel Resolution Retina Retinal Ganglion Cells Sample Size Sampling Scanning Site Societies Specificity Spinal Cord Structure Study Subject Symptoms Testing Thinking Time Translations Vision Visual Visual Acuity Visual Pathways Visual impairment Work adaptive optics aged base candidate marker clinical predictors clinically relevant cost disability disorder control feature detection ganglion cell imaging biomarker in vivo life time cost meetings middle age nervous system disorder novel retinal imaging

项目摘要

PROJECT SUMMARY Multiple sclerosis (MS) is a devastating neuro-degenerative disease that causes visual impairment in young, middle aged and older adults with resulting substantial lost productivity and cost to society. Current thinking attributes vision loss in MS to death and dysfunction of the retinal ganglion cells (RGCs) that comprise the optic nerve. However, there is only weak correlation between visual function and RGC atrophy, and some patients without RGC atrophy have vision loss, suggesting that all relevant contributors to vision loss in MS have not been identified. We have discovered structural features in the foveal avascular zone (FAZ) of retinas of the majority people with MS and a minority of people with glaucoma that cast a shadow on the photoreceptor layer and correlate with visual function. Our discovery contributes to addressing gaps in understanding visual pathway involvement in MS, offering new windows into diagnosis and treatment of vision loss in MS. This project studies the recently discovered FAZ features in retinas of people with MS and related diseases using adaptive optics scanning light ophthalmoscopy, a high resolution, non-invasive, state-of-the-art imaging technique. In the first aim, the relationship between central visual function and FAZ features will be defined using MS as an experimental model. Advanced microperimetry will be used to test the hypothesis that photoreceptor shadowing is the mechanism of vision loss. In the second aim the cause and composition of the FAZ features will be inferred through longitudinal studies of people with MS, cross sectional comparison between MS, glaucoma and related neurological and ophthalmic diseases and histopathological study of ex-vivo MS eyes. In the third aim rapid imaging protocols will be developed to enable faster detection of FAZ features and these will be applied to estimate the distributions of FAZ features in the populations with MS, glaucoma, other diseases and controls. These observations will evaluate the candidacy of the FAZ features as biomarkers of MS by defining specificity. The immediate impact of this research will be advancing understanding of vision loss in MS, developing rapid imaging strategies to enable broader study of large sample sizes at multiple sites and evaluating FAZ features as biomarkers in MS, glaucoma and other disease.

项目总结