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Core C: Medicinal Chemistry and DMPK

核心 C：药物化学和 DMPK

基本信息

批准号：
10522807
负责人：
Thomas D Bannister
金额：
$ 1314.19万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-16 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10522807
关键词：
Antiviral Agents Area Biochemical Biological Assay Blood Cells Chemicals Chicago Cluster Analysis Collaborations Cryoelectron Microscopy DNA Development Dose Drug Kinetics Ebola Human Resources Illinois In Vitro Industrialization Lead Libraries Liver Microsomes Metabolism Midwestern United States Minnesota Mississippi Modification Oral Patients Permeability Pharmaceutical Chemistry Pharmaceutical Preparations Philosophy Prevention Problem Solving Property Research Research Personnel Resources Risk Roentgen Rays Role SARS-CoV-2 entry inhibitor SARS-CoV-2 inhibitor Safety Schedule Scientist Series Site Solubility Structure Structure-Activity Relationship Therapeutic Toxic effect Translations Triage Virus Work analog antiviral drug development base clinical development clinical translation computational chemistry design drug candidate drug development drug discovery drug distribution drug metabolism efficacy study experience follow-up helicase high risk high throughput screening in vivo insight interest multidisciplinary novel pandemic disease pathogen pathogenic virus pharmacokinetics and pharmacodynamics preclinical development scaffold screening small molecule structural biology success targeted agent translational potential

项目摘要

Core C – Medicinal Chemistry and DMPK ABSTRACT The discovery of possible drug candidates requires effective collaboration of diverse teams of skilled scientists. Medicinal chemists fulfill a core problem solving role, generally leading efforts to overcome the myriad of obstacles sure to be encountered in any drug discovery campaign. A great many of these hurdles typically involve overcoming deficiencies in drug metabolism and pharmacokinetic (DMPK) properties. Core C of the Midwest AViDD Center centralizes medicinal chemistry and DMPK support functions, with a key role for computational chemistry in impacting hit-to-lead efforts. Core C is comprised of top researchers in their fields, located at 8 different research sites: Scripps-FL, U. Minnesota, Georgia State U, U. Illinois-Chicago, U. Mississippi, N.Y. Blood Center, U.C San Diego, and U.C. Berkeley. The effort seeks not to merely validate new targets and discover “probes” that are ill-suited for development but is focused on the delivery of agents with high translational potential. This philosophy derives in part from the extensive industrial experience of many key personnel in the core. Objectives include the identification and triage of validated hit series, their optimization to validated leads, and finally to the delivery of tractable orally bioavailable drug development candidates in multiple target areas for viruses with high pandemic potential.

核心C -药物化学和DMPK