Neuroendocrine control of synaptic connectivity.
突触连接的神经内分泌控制。
基本信息
- 批准号:10522227
- 负责人:
- 金额:$ 51.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-15 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:AdultAfferent NeuronsAgonistAnatomyAnimal ModelAnimalsAttentionBehaviorBehavioralBehavioral AssayBeta CellBilateralBiological ModelsBiological ProcessBrainBrain imagingCaenorhabditis elegansCalciumCellsCerebral DominanceDefectDevelopmentElectronsEnvironmentEnvironmental Risk FactorExhibitsExposure toFoundationsGeneticGenetic TranscriptionGenetic studyGoalsGuanylate CyclaseHeartHormonalHumanImageIndividualInsulinInsulin ReceptorIonsKnock-outLabelLanguageLeftLinkLiverLocomotionMeasurableMediatingMental DepressionMental disordersMicroscopicMolecularMorphologyNematodaNeuronsNeurosciencesNeurosecretory SystemsOrganPost-Traumatic Stress DisordersPsychologyResearchResolutionRoleSchizophreniaSensoryShapesSignal PathwaySodium ChlorideSpace PerceptionStructureSumSynapsesTaste BudsTestingTimeTransgenic OrganismsTranslatingTranslationsWorkantagonistautism spectrum disorderbasebehavioral studycognitive abilityexperienceexperimental studygenetic manipulationhormonal signalsimaging studyinsightinsulin signalingneural circuitneural networkneuropsychiatric disorderneuropsychiatryoptogeneticsprogramsreceptorreceptor expressionreceptor functionreconstructionresponsevisual processing
项目摘要
PI: Buelow, Hannes E.
Project Summary
The general body plan of most animals follows a bilateral symmetry. Some organs such as the heart and
liver break this gross anatomical symmetry, while other structures such as the brain display a superficial
bilaterally symmetric anatomy. Nonetheless, it has been known for a long time that the two hemispheres of the
human brain serve distinct functions, and many classical examples in neuroscience and psychology have
shown the importance of asymmetry in brain function. For example, higher order cognitive abilities such as
language, spatial orientation, attention, and visual processing exhibit left-right (L-R) functional asymmetries in
humans. Of note, many neuropsychiatric conditions including autism spectrum disorders, depression,
schizophrenia, and post-traumatic stress disorder display defects in brain laterality, further underscoring the
importance of lateralized brain function. Not surprisingly, neuropsychiatric conditions often have a genetic and,
hence possibly, a developmental component. Most of these conditions are also influenced by environmental
factors, yet how the environment interfaces with connectivity remains largely unknown. We have identified an
asymmetric synaptic connection between two pairs of sensory neurons in the nematode Caenorhabditis
elegans that changes in response to experience. Importantly, this connection is controlled cell-non-
autonomously from other cells by insulin signaling, which in turn is regulated by experience. This provides a
paradigm to investigate, on a molecular level and in single cell resolution, how the environment can change
hardwiring of a neural circuit in an experience-dependent manner. The goal of this proposal is to investigate
the developmental, plastic and functional aspects of this connection using C. elegans as a model system. In
Specific Aim 1, we will determine the mechanisms by which experience changes connectivity. We will
determine whether transcription or translation is required and whether neuronal activity is necessary and
sufficient, and in which cells. In Specific Aim 2, we will determine the role of insulin signaling in controlling
synaptic connectivity. Specifically, we will test which insulin-like agonists and antagonists function in which
cells to effect the changes in connectivity; where the receptor functions and in which genetic context. Lastly, in
Specific Aim 3, we will determine how changes in connectivity translate into changes in information flow and
behavior using whole brain calcium imaging and behavioral experiments. In sum, our research program aims
to establish the mechanisms, by which the environment changes synaptic hardwiring and behavior in the
context of an asymmetric synaptic connection.
PI:你好,汉内斯·E。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hannes Erich Buelow其他文献
Hannes Erich Buelow的其他文献
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{{ truncateString('Hannes Erich Buelow', 18)}}的其他基金
Genetic Analyses of Dendrite Morphogenesis in Caenorhabditis Elegans
秀丽隐杆线虫树突形态发生的遗传分析
- 批准号:
10736702 - 财政年份:2023
- 资助金额:
$ 51.21万 - 项目类别:
Neuroendocrine Control of Synaptic Connectivity.
突触连接的神经内分泌控制。
- 批准号:
10617839 - 财政年份:2022
- 资助金额:
$ 51.21万 - 项目类别:
A Fluorescence-Based High-Throughput Platform for Glycotyping the Hematopoietic Cell Lineage
基于荧光的造血细胞谱系糖分型高通量平台
- 批准号:
10248374 - 财政年份:2019
- 资助金额:
$ 51.21万 - 项目类别:
A Fluorescence-Based High-Throughput Platform for Glycotyping the Hematopoietic Cell Lineage
基于荧光的造血细胞谱系糖分型高通量平台
- 批准号:
10004021 - 财政年份:2019
- 资助金额:
$ 51.21万 - 项目类别:
A Fluorescence-Based High-Throughput Platform for Glycotyping the Hematopoietic Cell Lineage
基于荧光的造血细胞谱系糖分型高通量平台
- 批准号:
9813902 - 财政年份:2019
- 资助金额:
$ 51.21万 - 项目类别:
Genetic Analyses of Dendrite Development in Caenorhabditis elegans
秀丽隐杆线虫树突发育的遗传分析
- 批准号:
9327082 - 财政年份:2016
- 资助金额:
$ 51.21万 - 项目类别:
Genetic Analyses of Dendrite Development in Caenorhabditis elegans
秀丽隐杆线虫树突发育的遗传分析
- 批准号:
9239433 - 财政年份:2016
- 资助金额:
$ 51.21万 - 项目类别:
Genetic Analyses of Heparan Sulfate Function in Cell-Cell Interactions
硫酸乙酰肝素在细胞-细胞相互作用中功能的遗传分析
- 批准号:
8598913 - 财政年份:2013
- 资助金额:
$ 51.21万 - 项目类别:
Genetic Analyses of Heparan Sulfate Function in Cell-Cell Interactions
硫酸乙酰肝素在细胞-细胞相互作用中功能的遗传分析
- 批准号:
8438887 - 财政年份:2013
- 资助金额:
$ 51.21万 - 项目类别:
Establishing the Role of a Novel Conserved Gene in Dendrite Morphogenesis
建立新型保守基因在树突形态发生中的作用
- 批准号:
8656823 - 财政年份:2013
- 资助金额:
$ 51.21万 - 项目类别:
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