Effects of binge alcohol drinking on synaptic computing in the nucleus accumbens

这项行政补充研究拨款正在寻求资金，以培训马萨诸塞州大学医学院的蒂米·勒 符合NOT-OD-20-031代表不足B类和 C.这项行政补充拨款提案的目标是识别细胞 从随意饮酒到持续饮酒的早期转变的基础 模特。在这个项目的过程中，Timmy Le将学习使用和实现各种 互补方法，包括小鼠遗传学、光遗传学、行为学和生物物理学 检验计算大脑皮质突触强度这一总体假设的方法 杏仁核的输入(一种也称为突触门控的现象)是一种使 伏隔核是整合认知和情绪信息的中棘神经元，以及 是通过酒精暴露来控制消费的。除了获得新的技术 技能方面，他还将接受药物滥用概念方面的强化培训，并接受口头和 书面表达能力。

This admistrative supplement research grant is seeking funding to train Timmy Le, a UMass Medical School graduate student eligible under the NOT-OD-20-031 Underrepresented Categories B and C. The ambition of this administrative supplement grant proposal is to identify the cellular underpinnings of the early transition between casual to sustain drinking using drinking-in-the-dark model. Over the course of this project, Timmy le will learn to use and implement a variety of complementary approaches, including mouse genetics, optogenetics, behavior and biophysical approaches to test the overarching hypothesis that computing of the synaptic strength of cortical and amygdala inputs (a phenomenon also known as synaptic gating) is a mechanism enabling nucleus accumbens medium spiny neurons to integrate cognitive and emotional information, and is modulated by alcohol exposure to control consumption. In addition to acquiring new technical skills, he will also receive intense training in conceptual aspects of drugs of abuse and in oral and written presentation skills.