Administrative Core

摘要-行政核心 杜克自闭症卓越中心（ACE）的总体目标是使用一个转化的数字健康和 计算方法，以解决更有效的早期自闭症筛查工具的迫切需要，目的 和敏感的结果指标，以及可用于年轻人临床试验的基于大脑的生物标志物， 自闭症儿童我们将通过利用共享技术、计算方法和 在三个项目的临床专业知识和三个核心的支持下：传播和推广 核心、数据管理和分析核心以及管理核心。行政核心将服务于 作为中心的“枢纽”，协调和监督所有项目和核心，使其有效运作， 以综合和协同的方式有效地作为一个整体。行政核心将促进一个包容、 研究者之间公平的沟通和协作环境，减少行政负担 提供财务监督，监督监管合规性，并确保科学严谨性， 生产力核心研究将由中心主任兼主要研究者Geraldine Dawson博士指导， 我将与专家行政人员，内部执行委员会，社区参与 咨询委员会和外部咨询委员会。行政核心有三个具体目标。第一、 核心小组将协调中心调查人员之间的沟通、数据共享和协作，以加强 跨项目协同作用、共享专门知识和资源，以及科学进展， 研究计划。第二，核心将对中心进行全面管理和监督。芯会 通过设定目标、定义可交付成果和监测，监督和支持中心的科学工作 进度，确保及时向里程碑和可交付成果迈进。第三，核心将及时提供 财务会计，并确保遵守机构，州和联邦研究和道德准则， 质量控制和成本效益。核心将负责提供专门知识和基础设施， 强有力的财务管理;确保遵守大学、州、NIH和其他联邦研究 法规;管理机构审查委员会的提交和沟通;制定和 传播标准操作规程;实施药物临床试验质量管理规范;保持研究 忠诚度;监督质量控制;并确保及时提交给国家自闭症数据库 Research.

ABSTRACT – Administrative Core The overall goal of the Duke Autism Center of Excellence (ACE) is to use a translational digital health and computational approach to address the critical need for more effective early autism screening tools, objective and sensitive outcome measures, and brain-based biomarkers that can be used in clinical trials with young autistic children. We will achieve our goals by harnessing shared technologies, computational methods, and clinical expertise across three Projects and with the support of three Cores: The Dissemination and Outreach Core, the Data Management and Analysis Core, and the Administrative Core. The Administrative Core will serve as the Center’s “hub”, coordinating and overseeing all Projects and Cores so they function effectively and efficiently as a whole in an integrated and synergistic fashion. The Administrative Core will promote an inclusive, equitable environment of communication and collaboration among investigators, reduce administrative burden on investigators, provide financial oversight, monitor regulatory compliance, and ensure scientific rigor and productivity. The Core will be directed by Center Director and Principal Investigator, Dr. Geraldine Dawson, who will work closely with expert administrative staff, an internal Executive Committee, a Community Engagement Advisory Board, and an External Advisory Committee. The Administrative Core has three specific aims. First, the Core will coordinate communication, data-sharing, and collaboration among Center investigators to enhance cross-Projects synergies, shared expertise and resources, and scientific progress through all phases of the research program. Second, the Core will provide overall management and oversight of the Center. The Core will oversee and support the Center’s scientific efforts by setting goals, defining deliverables, and monitoring progress, ensuring timely advancement toward milestones and deliverables. Third, the Core will provide timely financial accounting and ensure compliance with institutional, state, and federal research and ethical guidelines, quality control, and cost-effectiveness. The Core will be responsible for providing expertise and infrastructure for strong financial management; ensuring compliance with university, state, NIH, and other federal research regulations; managing Institutional Review Board submissions and communication; developing and disseminating Standard Operating Procedures; implementing Good Clinical Practice; maintaining research fidelity; overseeing quality control; and ensuring timely submissions to the National Database for Autism Research.