Examining the Interplay of Negative Social Experiences and Self-Criticism on Suicide Risk in the Lab and Daily Life

检查负面社会经历和自我批评对实验室和日常生活中自杀风险的相互作用

• 批准号: 10535283
• 负责人: Lauren Haliczer
• 金额: $ 6.68万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10535283
• 关键词: Acute; Address; Affect; American; Applications Grants; Behavioral; Characteristics; Child Sexual Abuse; Childhood; Conflict (Psychology); Conscious; Data; Data Collection; Development; Ecological momentary assessment; Emotional; Emotions; Environment; Exclusion; Exposure to; Family; Feeling suicidal; Fostering; Frequencies; Funding; Future; Goals; Guilt; Hospitals; Individual; Infrastructure; Inpatients; Intervention; Knowledge; Laboratories; Lead; Life; Link; Literature; Manuscripts; Measures; Memory; Mentorship; Methodology; Modeling; National Institute of Mental Health; National Research Service Awards; Outcome; Participant; Patient Self-Report; Persons; Preparation; Prevention; Protocols documentation; Public Health; Recording of previous events; Research; Research Personnel; Resources; Risk; Risk Assessment; Risk Behaviors; Risk Factors; Risk Management; Sampling; Self-Injurious Behavior; Severities; Shame; Sleep; Social Desirability; Social Environment; Standardization; Stress; Suicide; Suicide attempt; Suicide prevention; Testing; Time; Training; Training Programs; Trauma; Universities; Work; advanced analytics; analytical tool; base; behavior measurement; career; clinical risk; critical period; emotional factor; emotional reaction; experience; high risk; ideation; improved; innovation; interpersonal trauma; medical schools; negative affect; pediatric trauma; recruit; reducing suicide; risk prediction; risk prediction model; skills; social; social exclusion; social factors; social networking website; stressor; suicidal behavior; suicidal morbidity; suicidal risk; tool; trait

Project Summary/Abstract This National Research Service Award will provide essential training and resources for the PI to facilitate her goal of becoming an independent investigator, focused on the prediction, prevention, and treatment of suicidal thoughts and behaviors (STB). Suicide is a major public health concern, with rates steadily rising; despite decades of research focused on prediction, our ability to predict when individuals are at high-risk of engaging in STB remains poor. Identifying periods of acute risk is critical in informing suicide prevention and intervention efforts. Research suggests that negative interpersonal experiences (e.g., childhood trauma, rejection) are associated with STB. However, these experiences are often uncontrollable, and tend to be measured retrospectively via self-report; identifying potential modifiable mechanisms that explain how such negative interpersonal experiences may lead to acute STB risk is vital. Increases in self-criticism is one candidate mechanism (e.g., parental rejection leads to STB via elevated self-criticism). However, self-criticism is often measured at the broad trait level; it is possible that undergoing an acute negative interpersonal experience may prompt immediate increases in state self-criticism and associated self-conscious emotions, and that this then places an individual at imminent risk for STB. The present study will address these gaps in the literature by exploring whether acute increases in self-criticism and self-conscious emotional reactions to (1) a lab-based interpersonal stressor, and (2) interpersonal stressors in daily life predict imminent risk for STB (measured both in the lab and on a momentary basis). Data collection for this innovative project will build upon an ongoing study (R01MH124832); we aim to recruit 85 participants from an inpatient hospital at high risk for suicide. In the lab, we will manipulate social exclusion with a well-tested paradigm (i.e., Cyberball), and measure participants’ state self-criticism and self-conscious affect (shame, guilt), as well as lifetime STB. Participants will also complete 4 weeks of ecological momentary assessment (EMA). This project will be conducted with an individualized training program to facilitate the acquisition of key skills and knowledge to move the applicant towards her career goals. This includes advanced didactic and experiential training in (1) EMA methodology, (2) acute suicide risk prediction models, (3) risk assessment and management in a high-risk clinical sample, (4) advanced statistical tools for analyzing intensive longitudinal data, and (5) grantsmanship and manuscript preparation. The applicant will work closely with her Sponsor, Dr. Armey (expert in EMA and suicide), and her Co-Sponsors Dr. Schatten (expert in EMA and risk management), Dr. Nugent (expert in social contexts of risk and childhood trauma), and Dr. Brick (expert in statistical tools for intensive longitudinal data). This outstanding mentorship team, in combination with the infrastructure and resources available through Butler Hospital and Alpert Medical School of Brown University, represents the ideal environment to accomplish the applicant’s training goals, foster her professional development, and increase her autonomy as a suicide researcher.

项目概要/摘要 该国家研究服务奖将为 PI 提供必要的培训和资源，以帮助她 成为一名独立研究者的目标，专注于自杀的预测、预防和治疗 思想和行为（STB）。自杀是一个主要的公共卫生问题，自杀率稳步上升；尽管 数十年的研究专注于预测，即我们预测个人何时处于参与高风险的能力 STB 仍然很差。识别急性风险期对于预防和干预自杀至关重要 努力。研究表明，负面的人际经历（例如童年创伤、拒绝） 与机顶盒有关。然而，这些经历往往是无法控制的，并且往往是可以衡量的 通过自我报告追溯；确定潜在的可修改机制，解释这种负面影响是如何产生的 人际经历可能导致急性STB风险至关重要。增加自我批评是其中之一 机制（例如，父母的拒绝通过提高自我批评导致 STB）。然而，自我批评往往是 在广泛的特质水平上进行衡量；有可能经历严重的负面人际经历 可能会促使国家自我批评和相关的自我意识情绪立即增加，并且这 然后将个人置于迫在眉睫的 STB 风险之中。本研究将解决文献中的这些空白 通过探索自我批评和自我意识情绪反应是否会急剧增加（1）基于实验室的 人际压力源，以及 (2) 日常生活中的人际压力源预测即将发生 STB 的风险（同时测量 在实验室中并且是暂时的）。这一创新项目的数据收集将建立在持续进行的基础上 研究（R01MH124832）；我们的目标是从一家住院医院招募 85 名自杀高危参与者。在 在实验室中，我们将通过经过充分测试的范例（即网络球）来操纵社会排斥，并测量 参与者陈述自我批评和自我意识情感（羞耻、内疚），以及终生 STB。参加者 还将完成为期4周的生态瞬时评估（EMA）。该项目将与一个 个性化培训计划，促进关键技能和知识的获取，打动申请人 朝着她的职业目标。这包括 (1) EMA 方法的高级教学和体验式培训， (2) 急性自杀风险预测模型，(3) 高风险临床样本的风险评估和管理，(4) 用于分析密集纵向数据的先进统计工具，以及（5）资助和手稿 准备。申请人将与她的担保人 Armey 博士（EMA 和自杀专家）以及她的密切合作 共同发起人 Schatten 博士（EMA 和风险管理专家）、Nugent 博士（风险社会背景专家） 和童年创伤）和布里克博士（密集纵向数据统计工具专家）。这个杰出的 导师团队，结合巴特勒医院和巴特勒医院提供的基础设施和资源 布朗大学阿尔珀特医学院代表了完成申请人学业的理想环境 培训目标，促进她的专业发展，并增加她作为自杀研究者的自主权。