Minimally Invasive Tissues Sampling to Evaluate HIV-associated Meningitis in Zambia
赞比亚通过微创组织取样评估艾滋病毒相关脑膜炎
基本信息
- 批准号:10536463
- 负责人:
- 金额:$ 47.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-15 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAfrica South of the SaharaAfricanAreaAutomobile DrivingAutopsyBiological AssayBiological MarkersBiopsy SpecimenBrainBurialCaringCentral Nervous System InfectionsCerebrospinal FluidCessation of lifeClinicalClinical ManagementCollectionCore BiopsyCountryDiagnosisDiagnosticEtiologyEvaluationFamilyFellowshipFutureGoalsHIVHIV SeropositivityHIV diagnosisHistologicHistologyHourIncidenceInfectionInpatientsInvestigationKnowledgeLaboratoriesLipidsMeasuresMeningeal TuberculosisMeningitisMetagenomicsMethodsMicrobiologyMolecularMycobacterium tuberculosisNeuraxisOrganOrganismOutcomePathologistPathologyPatient-Focused OutcomesPatientsPolymerase Chain ReactionPopulationPreparationPrevalenceRapid diagnosticsReligious BeliefResearchResource-limited settingRoleSamplingServicesSiteSpecificitySpinal PunctureSymptomsTabooTestingTimeTissue SampleTissuesTrainingZambiabrain tissueco-infectioncomorbiditydiagnostic biomarkerdiagnostic strategydoctoral studentimprovedimproved outcomeinnovationinsightlateral flow assaylipidomicslipoarabinomannanlow and middle-income countriesminimally invasivemolecular diagnosticsmortalitymycobactinsneuropathologynext generation sequencingpathogenpoint of carepoint-of-care diagnosticsportabilitypreventprogramspublic health relevancescreeningtreatment strategyuptake
项目摘要
There is an urgent need to establish the etiology and improve diagnostics of HIV-associated
meningitis in countries like Zambia given the high rates of mortality. A lack of post-mortem studies
in low and middle-income countries prevents in-depth studies on tissue from confirmed meningitis
patients. Central nervous system (CNS) co-infection frequently occurs in HIV-associated
meningitis, but no study has investigated its impact on mortality. Tuberculous meningitis (TBM),
one of the most common causes of HIV-associated meningitis, lacks a sensitive cerebrospinal
fluid (CSF) lateral flow assay to serve as a simple point of care diagnostic. The best candidate
lipid biomarker for a point of care assay has not been established. Best practices and expertise
for CSF and brain tissue handling, processing, and analyses are also lacking in many sub-
Saharan African countries. Our long-term goal is to establish causes of mortality, optimal
diagnostic biomarkers, and laboratory expertise to improve outcomes of HIV-associated
meningitis. We will test the following set of specific aims:
Aim 1) Establish comprehensive etiologies of HIV-associated meningitis
Aim 2) To improve CSF diagnostics for patients with HIV-associated meningitis in
resource-limited settings, we will explore more optimal candidate CSF lipid biomarkers to
diagnose TBM.
Aim 3) Strengthen laboratory services to improve the diagnosis of meningitis
The approach is innovative, because it systematically uses post-mortem tissue from an endemic
setting to evaluate HIV-associated meningitis. The proposed research is significant because it
allows us to establish etiologies and diagnostic biomarkers in HIV-associated meningitis while
improving the laboratory capability in Zambia to diagnose CNS infections. These findings will have
an important impact on the clinical management of meningitis and provide specific evidence to
guide empiric treatment of patients in the future.
目前迫切需要确定艾滋病毒相关性肺炎的病因并改进诊断方法。
在赞比亚等国,由于死亡率高,缺乏尸检研究
在低收入和中等收入国家,
患者中枢神经系统(CNS)合并感染经常发生在HIV相关的
脑膜炎,但没有研究调查其对死亡率的影响。脑膜炎(TBM),
艾滋病毒相关脑膜炎的最常见原因之一,缺乏敏感的脑脊液
液体(CSF)侧流测定用作简单的护理点诊断。最佳人选
尚未建立用于护理点测定的脂质生物标志物。最佳做法和专门知识
对于CSF和脑组织的处理、加工和分析,
撒哈拉非洲国家。我们的长期目标是确定死亡原因,
诊断生物标志物和实验室专业知识,以改善艾滋病毒相关的
脑膜炎我们将测试以下一组具体目标:
目的1)建立HIV相关脑膜炎的综合病因学
目的2)提高对HIV相关脑膜炎患者的CSF诊断,
在资源有限的情况下,我们将探索更佳的候选CSF脂质生物标志物,
诊断TBM。
目的3)加强化验服务,提高脑膜炎的诊断水平
这种方法是创新的,因为它系统地使用了一种流行病的死后组织,
以评估HIV相关脑膜炎。这项研究意义重大,因为它
使我们能够建立HIV相关脑膜炎的病因学和诊断生物标志物,
提高赞比亚诊断中枢神经系统感染的实验室能力。这些发现将
对脑膜炎的临床管理产生重要影响,并提供具体证据,
指导今后患者的经验性治疗。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Omar Khalik Siddiqi其他文献
Omar Khalik Siddiqi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Omar Khalik Siddiqi', 18)}}的其他基金
Minimally Invasive Tissues Sampling to Evaluate HIV-associated Meningitis in Zambia
赞比亚通过微创组织取样评估艾滋病毒相关脑膜炎
- 批准号:
10644009 - 财政年份:2022
- 资助金额:
$ 47.22万 - 项目类别:
Novel CSF Diagnostics and Genotype Markers of Tuberculous Meningitis in Zambia
赞比亚结核性脑膜炎的新型脑脊液诊断和基因型标记
- 批准号:
8914052 - 财政年份:2014
- 资助金额:
$ 47.22万 - 项目类别:
Novel CSF Diagnostics and Genotype Markers of Tuberculous Meningitis in Zambia
赞比亚结核性脑膜炎的新型脑脊液诊断和基因型标记
- 批准号:
9134889 - 财政年份:2014
- 资助金额:
$ 47.22万 - 项目类别:
Novel CSF Diagnostics and Genotype Markers of Tuberculous Meningitis in Zambia
赞比亚结核性脑膜炎的新型脑脊液诊断和基因型标记
- 批准号:
8789125 - 财政年份:2014
- 资助金额:
$ 47.22万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 47.22万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 47.22万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 47.22万 - 项目类别:
Standard Grant
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 47.22万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 47.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 47.22万 - 项目类别:
Discovery Early Career Researcher Award
RUI: Evaluation of Neurotrophic-Like properties of Spaetzle-Toll Signaling in the Developing and Adult Cricket CNS
RUI:评估发育中和成年蟋蟀中枢神经系统中 Spaetzle-Toll 信号传导的神经营养样特性
- 批准号:
2230829 - 财政年份:2023
- 资助金额:
$ 47.22万 - 项目类别:
Standard Grant
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 47.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 47.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 47.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)