ShEEP Request for Noldus EthoVision XT System

ShEEP 请求 Noldus EthoVision XT 系统

• 批准号: 10534037
• 负责人: ADVIYE ERGUL
• 金额: --
• 依托单位: RALPH H JOHNSON VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10534037
• 关键词: Affect; Alcohol dependence; Alzheimer' s Disease; Animal Experimentation; Animals; Anxiety Disorders; Aortic Aneurysm; Behavior; Behavior assessment; Behavioral; Behavioral Research; Biochemical; Biomedical Research; Blood Pressure; Body Temperature; Brain; Cardiovascular system; Cells; Cerebrovascular Disorders; Complement; Complex; Computer software; Consultations; Core Facility; Data; Degenerative polyarthritis; Dementia; Discipline; Disease; Disease Progression; Disease model; Drug Addiction; Electrocardiogram; Environment; Evaluation; Feedback; Fees; Fostering; Goals; Health; Heart Diseases; Heart failure; Histology; Hypertension; Image; Immunology; Injury; International; Intervention; Link; Logistics; Maintenance; Medical; Medical center; Mental Depression; Methodology; Minor; Mission; Modeling; Molecular; Multiple Sclerosis; Mus; Musculoskeletal; Operative Surgical Procedures; Organ; Outcome; Participant; Pathology; Peripheral; Phenotype; Physiological; Physiology; Post-Traumatic Stress Disorders; Protocols documentation; Rattus; Rehabilitation therapy; Research; Research Personnel; Rodent; Rodent Model; Schedule; Services; Sheep; Spinal cord injury; Stem Cell Development; Strategic Planning; Stroke; Structure; System; Technology; Telemetry; Time; Training; Traumatic Brain Injury; Treatment Efficacy; Vascular Dementia; Veterans; base; body system; bone fracture repair; chronic pain; clinically relevant; conflict resolution; design; efficacy testing; functional outcomes; instrumentation; member; novel; novel therapeutics; post stroke cognitive impairment; recruit; stroke recovery; surgical research; tool; translational potential

The primary goal of this proposal is to establish a Functional Behavior Assessment/Phenotyping Core for clinically relevant rat models of disease that are highly critical for the advancement of translational biomedical research. The need for this critical core is based on several factors. First, in the last two years, the research portfolio that involves behavioral analyses and the number of investigators who use rat models have substantially increased at the Ralph H. Johnson VA Medical Center (RHJ VAMC). Second, with the recent advances in technology, the genetically modified rat models are becoming available, and this is highly attractive for our investigators who use complex instrumentation. The availability of a “rat” core will enable us to be at the forefront of this line of research. Third, the need for a “systems physiology approach” in behavioral research is increasingly recognized as complex brain-peripheral organ axes are being unraveled in many diseases including traumatic brain injury (TBI), spinal cord injury (SCI), stroke, dementia, and post-traumatic stress disorders (PTSD), depression and anxiety disorders, drug and alcohol addiction, chronic pain, cardiac disease including heart failure, hypertension and aortic aneurysms, and musculoskeletal pathologies (fracture healing, osteoarthritis, multiple sclerosis), all of which disproportionately affect our Veterans. Accordingly, we propose to establish a core with an integrated system of behavior (designed for rats) and telemetry hardware that is driven by a central software control platform. The Noldus EthoVision XT System represents a state-of-the-art integrated system allowing for automated, quantitative, comprehensive behavioral and physiological assessment for each animal as a function of time, injury model, disease progression, or intervention. Using this integrative technology, four primary aims will pursued: 1) Provide a research platform that facilitates basic discovery with high translational potential; 2) Develop a research environment that fosters cross cultivation of disciplines to identify novel links between organ systems and diseases; 3) Test the efficacy of therapeutic strategies and interventional methodologies on functional outcomes and identify “personalizable” targets. and 4) Integrate behavioral, physiological and biochemical outcomes to provide comprehensive analysis of disease models. The Functional Behavior Assessment/Phenotyping Core is a necessity for the diverse research efforts of our local VAMC investigators who investigate TBI/SCI, stroke recovery, dementia, PTSD, chronic pain, cardio and cerebrovascular disease, immunology, and stem cell development and therapies. This Core will greatly strengthen the research capabilities of our station, serve as an excellent recruitment tool to attract new investigators to VA research, and facilitate basic scientific discovery leading to the rapid implementation of cutting-edge personalized medical treatment for our Veterans, a specific directive outlined in the Secretary’s Blueprint for Excellence that is directly relevant to the VA Mission.

该提案的主要目标是建立功能行为评估/表型核心 临床相关的大鼠疾病模型，对于转化生物医学的进步非常关键 研究。对这个关键核心的需求基于几个因素。首先，近两年的研究 涉及行为分析的投资组合和使用大鼠模型的研究人员数量显着增加 拉尔夫·H·约翰逊退伍军人医疗中心 (RHJ VAMC) 的发病率有所增加。其次，随着最近的进展 技术的进步，转基因大鼠模型的出现，这对我们来说非常有吸引力 使用复杂仪器的调查人员。 “老鼠”核心的出现将使我们走在最前沿 这一研究方向。第三，行为研究对“系统生理学方法”的需求日益增加 被认为是复杂的大脑-周围器官轴正在许多疾病中被解开，包括创伤性疾病 脑损伤（TBI）、脊髓损伤（SCI）、中风、痴呆和创伤后应激障碍（PTSD）， 抑郁症和焦虑症、药物和酒精成瘾、慢性疼痛、心脏病（包括心脏病） 衰竭、高血压和主动脉瘤以及肌肉骨骼病变（骨折愈合、骨关节炎、 多发性硬化症），所有这些都对我们的退伍军人产生了不成比例的影响。因此，我们建议设立一个 具有集成行为系统（专为老鼠设计）和由中央驱动器驱动的遥测硬件的核心 软件控制平台。 Noldus EthoVision XT 系统代表了最先进的集成系统 允许对每只动物进行自动化、定量、全面的行为和生理评估 作为时间、损伤模型、疾病进展或干预的函数。利用这种集成技术，四个 追求的主要目标：1）提供一个研究平台，促进高转化率的基础发现 潜在的; 2）开发一个促进学科交叉培养的研究环境，以发现新的联系 器官系统与疾病之间； 3）测试治疗策略和介入的效果 功能结果的方法论并确定“个性化”目标。 4）整合行为， 生理和生化结果提供疾病模型的综合分析。功能性 行为评估/表型核心是我们当地 VAMC 多样化研究工作的必要条件 调查 TBI/SCI、中风恢复、痴呆、创伤后应激障碍 (PTSD)、慢性疼痛、心脏病和 脑血管疾病、免疫学、干细胞发育和治疗。该核心将大大 加强本站的研究能力，作为吸引新人的优秀招聘工具 研究人员参与 VA 研究，并促进基础科学发现，从而导致快速实施 为我们的退伍军人提供尖端的个性化医疗，这是部长的一项具体指令 与 VA 使命直接相关的卓越蓝图。