BLR&D Research Career Scientist Award Application

BLR

• 批准号: 10047693
• 负责人: ADVIYE ERGUL
• 金额: --
• 依托单位: RALPH H JOHNSON VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10047693
• 关键词: Address; Administrative Supplement; Affect; American; American Heart Association; Animal Model; Animals; Appointment; Award; Biology; Blood Vessels; Blood flow; Brain; Brain Diseases; Cardiometabolic Disease; Cardiovascular Diseases; Cerebrovascular Disorders; Cerebrovascular system; Cerebrum; Chronic; Coagulation Process; Collaborations; Complications of Diabetes Mellitus; Dementia; Diabetes Mellitus; Disease; Disease model; Endocrinology; Extramural Activities; Failure; Female; Funding; Grant; Healthcare; Hypertension; Impaired cognition; Impairment; Injury; Intervention; Ischemic Brain Injury; Ischemic Stroke; Journals; Mentors; Microvascular Dysfunction; Mission; Molecular; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Neurological Disorders and Stroke; Neurons; Paper; Pathologic; Patients; Pattern; Pericytes; Pharmaceutical Preparations; Pharmacology; Physiology; Postdoctoral Fellow; Process; Program Research Project Grants; Publications; Publishing; Quality of life; Recovery; Recovery of Function; Research; Research Personnel; Risk; Risk Factors; Role; Scientist; Senior Scientist; Societies; Stroke; Structure; System; Training; Training Programs; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Veterans; Wages; Women' s Health; acute stroke; arteriole; brain repair; career; cognitive recovery; dementia risk; diabetic; disability; improved; injury recovery; innovation; ischemic injury; juvenile animal; male; military veteran; multidisciplinary; neovascularization; next generation; peer; post stroke; post stroke cognitive impairment; professor; programs; repaired; sex; stroke patient; stroke recovery; stroke therapy; success; vascular injury; vascular risk factor; working group

Stroke is the number one cause of disability in the US. This is a result of physical impairments as well as increased risk of dementia after stroke. High blood pressure is the top risk factor for stroke followed by diabetes. High blood pressure, diabetes and stroke are highly prevalent in our Veterans. Hypertension is the most common vascular risk factor among Veterans with stroke. Moreover, among Veterans, hypertension is the most common chronic condition, affecting more than 37% of the Veteran population. 25% of our Veterans have diabetes. Despite years of extensive research, all efforts to protect neurons from ischemic stroke injury failed. There is only one treatment for stroke and that is to open the occluded blood vessels with a clot-busting drug. There is NO treatment for dementia that develops after stroke. Reasons for this failure may be several fold: 1) researchers have used otherwise healthy and young animal models in research; 2) most studies utilized male animals; and 3) researchers have tried to salvage and repair only "neurons". It is now increasingly recognized that blood vessels of the brain are extremely critical for the acute stroke injury and chronic recovery. When blood flow to the brain is compromised, cognitive impairment ensues and recovery from stroke is impaired. Targets for new treatments may be different in females and/or diseases like diabetes and high blood pressure that are commonly found in patients with stroke or cognitive impairment. This is also quite relevant to VA mission as our female Veterans are steadily increasing among our Veterans and suffering from these diseases necessitating the VA to launch the “Women’s Health Initiative”. Dr. Ergul, a well-accomplished VA Research Career Scientist and Regents’ Professor at Augusta University, uses her uniquely combined expertise in endocrinology, physiology, pharmacology and vascular biology to address these gaps by studying the interaction of diabetes and high blood pressure with associated complications such as stroke and cognitive impairment in both sexes. She is extremely committed to improve the quality of life of our Veterans and our society, a commitment solidified by Research Career Scientist recognition in the last 5 years. Her commitment to VA and cardiovascular disease research is evidenced by 1) continuous extramural finding by National Institutes of Health, American Heart Association, American Diabetes Association, and Veterans Affairs in the last 20 years, 2) her over 150 publications (59 alone during the tenure of the RCS in the last 5 years), 3) success of renewing VA Merit Award twice during the current RCS award period, 4) receiving additional extramural funding to address complementary scientific questions, 5) her stature as a leader in the field and 6) the success of her mentoring next generation of scientists.

中风是美国第一大致残原因。这是由于身体缺陷以及 中风后患痴呆症的风险增加。高血压是中风的首要危险因素，其次是 糖尿病。高血压、糖尿病和中风在我们的退伍军人中非常普遍。高血压是 中风退伍军人中最常见的血管危险因素。此外，在退伍军人中，高血压是 最常见的慢性病，​​影响超过 37% 的退伍军人。 25% 的退伍军人 患有糖尿病。尽管经过多年的广泛研究，保护神经元免受缺血性中风损伤的所有努力 失败的。中风只有一种治疗方法，那就是用溶栓药物打开闭塞的血管 药品。中风后发生的痴呆症尚无治疗方法。造成这种失败的原因可能有几个 折叠：1）研究人员在研究中使用了其他健康且年轻的动物模型； 2）大多数研究 利用雄性动物； 3）研究人员试图仅挽救和修复“神经元”。现在越来越多 认识到大脑血管对于急性中风损伤和慢性中风损伤极为关键 恢复。当流向大脑的血液受到损害时，就会出现认知障碍并从中风中恢复 受到损害。新疗法的目标在女性和/或糖尿病和高血压等疾病中可能有所不同 中风或认知障碍患者中常见的血压。这也相当 与退伍军人事务部的使命相关，因为我们的女性退伍军人在退伍军人中稳步增加，并遭受 这些疾病迫使退伍军人管理局发起“妇女健康倡议”。 Ergul 博士，一位卓有成就的 VA 研究职业科学家和奥古斯塔大学摄政教授，利用她独特的结合 内分泌学、生理学、药理学和血管生物学方面的专业知识，通过研究来弥补这些差距 糖尿病和高血压与中风和认知等相关并发症的相互作用 两性都有损害。她非常致力于提高退伍军人和我们的生活质量 过去 5 年，研究职业科学家的认可巩固了这一承诺。她的承诺 VA 和心血管疾病研究的证据是 1) 国家连续的校外发现 健康研究所、美国心脏协会、美国糖尿病协会和退伍军人事务部 过去 20 年，2) 她发表了 150 多篇出版物（仅在过去 5 年 RCS 任期内就有 59 篇），3) 在当前 RCS 奖励期内成功续订 VA 优异奖两次，4) 获得额外奖励 用于解决补充科学问题的校外资金，5) 她作为该领域领导者的地位，以及 6) 她指导下一代科学家的成功。