Examining the long-term relationship between sleep and diet

项目总结/摘要 饮食质量差导致美国成年人心脏代谢疾病负担过重。短睡眠 和睡眠质量差的人越来越多，并与肥胖和心脏代谢疾病有关。有 有证据表明，饮食和睡眠时间和质量的减少都会影响非洲裔美国人和那些低 社会经济地位高于其他群体，这些差异可能有助于健康 心脏代谢疾病的差异。饮食的特定方面与睡眠结果有关， 短期和类似地，睡眠限制的实验研究发现，睡眠不足会导致不良的 饮食选择和体重增加，证明了饮食和睡眠关系的双向性， 近期然而，饮食和睡眠之间的相互关系是复杂的，很少被研究， 长期也不与持续时间以外的睡眠方面，包括质量，规律性，干扰， 困倦因此，本研究将通过研究长期关系来解决这一知识差距 在博加卢萨心脏研究队列中，来自一个社区的1250名男性和女性的饮食和睡眠之间的关系 在路易斯安那州，从童年开始，已经被前瞻性地跟踪了40多年。第一个目标 研究是前瞻性地检查睡眠的多个方面的影响（例如持续时间，质量，嗜睡） 在博加卢萨心脏研究队列中，研究的第二个目的是 前瞻性地研究成年早期饮食摄入对以后生活中长期睡眠结果的影响 包括睡眠持续时间、质量、规律性、干扰和嗜睡占体重指数、风险 治疗睡眠呼吸障碍和身体活动。第三个目标是确定种族差异， 生理性别、社会经济地位等因素在饮食与睡眠的关系中存在着生命历程的差异。 在追求这个研究项目和培训计划的长期目标是产生一个独立的调查员 在营养和生活方式流行病学，充分准备追求的研究事业，减轻负担， 海湾南部地区肥胖和肥胖相关发病率和死亡率的差异 美国的这将通过实现该项目的总体目标，实施一项量身定制的， 个性化的，指导性的研究培训经验，有助于关闭一个长期的知识 饮食和睡眠之间长期关系的差距。这项工作的影响将产生一个未来 营养和生活方式流行病学的领导者。所获得的知识将有助于发展 适当定时和有针对性的干预机会，以保持健康的体重和睡眠模式， 在美国不同人群中预防慢性心脏代谢疾病， 差距。博加卢萨心脏研究队列是进行这项研究的独特和理想的环境。

PROJECT SUMMARY/ABSTRACT Poor diet quality contributes to the excess burden of cardiometabolic diseases among U.S. adults. Short sleep and poor quality sleep are increasing and have been linked to obesity and cardiometabolic diseases. There is evidence that both diet and reduced sleep duration and quality impact African Americans and those with low socio-economic status more so than other groups, and that these differences may contribute to health disparities in cardiometabolic diseases. Specific aspects of diet have been linked to sleep outcomes in the short term and similarly, experimental studies of sleep restriction have found short sleep can lead to poor dietary choices and weight gain, demonstrating the bi-directionality of the diet and sleep relationship in the near term. However, the inter-relationship between diet and sleep is complex and has rarely been studied in the long-term nor with aspects of sleep beyond duration including quality, regularity, disturbance, and sleepiness. Therefor, this study will address this knowledge gap by examining the long-term relationships between diet and sleep in the Bogalusa Heart Study cohort of 1250 men and women from a biracial community in Louisiana that have been prospectively followed for over 40 years, since childhood. The first aim of the research is to prospectively examine the effect of multiple aspects of sleep (e.g. duration, quality, sleepiness) on dietary intake in midlife among the Bogalusa Heart Study cohort. The second aim of the research is to prospectively examine the effect of dietary intake in young adulthood on long-term sleep outcomes later in life including sleep duration, quality, regularity, disturbance, and sleepiness accounting for body mass index, risk for sleep disordered breathing, and physical activity. The third aim is to determine if differences by race, biologic sex, and socioeconomic status exist in the relationships between diet and sleep over the life course. The long-term goal in pursuing this research project and training plan is to produce an independent investigator in nutritional and lifestyle epidemiology, well prepared to pursue a research career that alleviates the burden of disparity in obesity and obesity-related morbidity and mortality for people in the Gulf South Region of the United States. This will be achieved by meeting the overall objective of this project, implementing a tailored, individualized, mentored research training experience that contributes to closing a long-standing knowledge gap in the long-term relationship between diet and sleep. The impact of this work will be to produce a future leader in nutritional and lifestyle epidemiology. The knowledge gained will allow for the development of appropriately timed and targeted intervention opportunities to maintain healthy weight and sleep patterns that prevent chronic cardiometabolic diseases among diverse populations in the U.S. while reducing health disparities. The Bogalusa Heart Study cohort is a unique and ideal setting in which to perform this research.