Improving Brain-Behavior Markers of Preschool Executive Function through aGroup-Based Parenting Intervention for Low-Income Families

通过针对低收入家庭的团体育儿干预改善学前执行功能的大脑行为标志

• 批准号: 10663529
• 负责人: Jennifer Suor
• 金额: $ 20.21万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663529
• 关键词: 5 year old; Address; Adolescence; Aftercare; Age; Area; Award; Behavior; Behavioral; Behavioral Mechanisms; Brain; Caregivers; Chicago; Child; Child Rearing; Childhood; Chronic; Clinical Trials; Community Mental Health Services; Conduct Disorder; Control Groups; Data; Development; Diagnostic; Discipline; Disruptive Behavior Disorder; Electroencephalography; Eligibility Determination; Enrollment; Ensure; Etiology; Evaluation; Executive Dysfunction; Family; Goals; Health Services Research; Illinois; Impairment; Individual Differences; Influentials; Informal Social Control; Intervention; Interview; Investigational Therapies; Knowledge; Link; Longevity; Low income; Measures; Mediating; Medicaid eligibility; Mental Health; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Modification; Monitor; National Institute of Mental Health; Neuronal Plasticity; Nursery Schools; Oppositional Defiant Disorder; Parents; Phase; Poverty; Prediction of Response to Therapy; Prevention program; Problem behavior; Psychiatry; Psychopathology; Publishing; Randomized; Recording of previous events; Reporting; Research; Research Domain Criteria; Risk; Sampling; Scientist; Stress; Surveys; Testing; Time; Training; Universities; Work; Youth; affective neuroscience; brain behavior; career; career development; clinical translation; cognitive control; cognitive performance; cognitive process; cognitive task; collaborative environment; community based research; comparison control; cost efficient; design; diagnostic criteria; dissemination science; early childhood; executive function; experience; follow-up; health disparity; implementation science; improved; indexing; lower income families; neural; neurophysiology; novel; parental influence; prevent; preventive intervention; programs; protective effect; psychosocial; randomized, clinical trials; recruit; scaffold; skills; theories; therapeutic target

PROJECT ABSTRACT Impairments in executive functioning (EF), cognitive processes that support self-regulation, disproportionately impact children living in poverty and increase vulnerability for childhood disruptive behavior disorders (DBDs; oppositional defiant disorder, conduct disorder), which trigger a cascade of mental health problems and psychosocial difficulties across the lifespan. Poverty-related stress and maladaptive parenting styles have been linked to alterations of neural and behavioral EF markers in children; despite this, no studies have studied if parenting prevention programs can directly target childhood EF, and through improving EF, reduce disruptive behaviors in at-risk children. This K23 Mentored Patient-Oriented Research Career Development Award application seeks to conduct a mechanistic randomized clinical trial to determine whether neural-behavioral indices of childhood EF is an experimental therapeutic target that can be modified via caregiver participation in the Chicago Parent Program (CPP; Aim 1). Consistent with the NIMH Research Domain Criteria framework, childhood EF will be assessed across multiple levels of analysis (electroencephalogram [EEG], behavior, survey). The project also seeks to evaluate whether increases in childhood neural-behavioral EF mediate the effects of CPP in reducing disruptive behavior problems over a short-term follow-up (Aim 2). The project will also explore whether increases in specific parenting practices (discipline, scaffolding), previously linked to individual differences in EF, mediate the effects of CPP in predicting change in childhood neural-behavioral EF (Aim 3). The sample will include 90 Medicaid eligible parent-child (ages 4-5 years old) dyads; and will employ a novel recruitment approach where the target child will have moderate-to-severe EF delays at baseline but does not meet diagnostic criteria for a DBD. Consistent with the candidate's translational clinical scientist career goals, the candidate seeks crucial training in: community-based research and dissemination and implementation science, advanced EEG methods to evaluate neural-behavioral EF targets of preventive interventions, and statistical skills to design and evaluate clinical trials. Training will occur in an outstanding interdisciplinary environment at the University of Illinois at Chicago, in the Department of Psychiatry and leverage the department's established strengths in community mental health services research, dissemination and implementation science, and affective neuroscience. Mentors Drs. Atkins, Fitzgerald and Bhaumik and consultants Drs. Klumpp, Wakschlag, Gross, and Handley have expertise in the training areas and extensive histories of early career mentorship, and will work together to ensure the candidate's successful transition to research independence. Study findings will support an R01 application to validate the results on a larger scale and launch the candidate's academic career as a preventive intervention scientist. Findings have significant potential to identify whether CPP, a cost-efficient parenting intervention, modifies neural-behavioral EF indices in urban poor children, a theorized etiological risk mechanism of DBDs, and therefore prevent DBDs.

项目摘要 执行功能障碍（EF），支持自我调节的认知过程，不成比例 影响生活在贫困中的儿童，并增加儿童破坏性行为障碍的脆弱性（DBD； 对立反抗疾病，行为障碍），这引发了一系列心理健康问题和 整个生命周期的社会心理困难。与贫困有关的压力和适应不良的育儿方式具有 与儿童的神经和行为EF标记的改变有关；尽管如此，尚无研究 如果预防育儿计划可以直接针对儿童EF，并通过改善EF，请减少破坏性 高危儿童的行为。这款K23指导了以患者为导向的研究职业发展奖 应用程序旨在进行机械随机临床试验，以确定是否神经行为 儿童期EF的指标是一个实验性治疗靶标，可以通过护理人员参与来修改 芝加哥父母计划（CPP； AIM 1）。与NIMH研究领域标准框架一致 童年EF将在多个分析（脑电图[EEG]，行为，， 民意调查）。该项目还试图评估儿童神经行为的增加是否介导 CPP在短期随访中减少破坏性行为问题的影响（AIM 2）。该项目将 还探讨了特定的育儿惯例（纪律，脚手架）是否有所增加，以前链接到 EF的个体差异，介导CPP在预测儿童神经行为EF变化方面的影响 （目标3）。该样本将包括90个医疗补助符合条件的亲子（4-5岁）二元组；并将采用 新颖的招聘方法，目标孩子在基线时会有中度至重度延误 不符合DBD的诊断标准。与候选人的翻译临床科学家职业一致 目标，候选人寻求重要的培训：基于社区的研究和传播和 实施科学，高级脑电图方法，用于评估预防性神经行为的范围目标 干预措施以及设计和评估临床试验的统计技能。培训将在出色的 伊利诺伊大学芝加哥大学，精神病学系的跨学科环境和 利用该部门在社区心理健康服务研究，传播方面的既定优势 和实施科学和情感神经科学。导师博士。阿特金斯，菲茨杰拉德和bhaumik以及 顾问博士。 Klumpp，Wakschlag，Gross和Handley在培训领域具有专业知识，并广泛 早期职业指导的历史，并将共同努力，以确保候选人的成功过渡到 研究独立性。研究结果将支持R01应用程序，以验证更大范围的结果 并启动候选人作为预防性干预科学家的学术生涯。发现很重要 潜力确定CPP（一种经济高效的育儿干预）是否修改了神经行为的EF指数 在城市贫困儿童中，DBD的理论上病因学风险机制，因此可以预防DBD。