Center for Harmonizing and Improving Interventions to Prevent Suicide (CHIIPS)

协调和改进预防自杀干预措施中心 (CHIIPS)

• 批准号: 10662785
• 负责人: Marianne Goodman
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662785
• 关键词: Address; Adult; Advisory Committees; Assessment tool; Biological Markers; Characteristics; Clinical; Clinical Trials; Collaborations; Communities; Complement; Consultations; Data; Data Analyses; Death Rate; Development; Disparity; Education; Effectiveness; Faculty; Fellowship; Funding; Funding Mechanisms; Goals; Grant Review; Growth; Guidelines; Individual; Infrastructure; Intervention; Leadership; Mentors; Mentorship; Methodology; Methods; Mission; Monitor; Outcome; Patients; Pilot Projects; Population; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Predictive Analytics; Prevention Research; Protocols documentation; Publishing; Qualifying; Recommendation; Research; Research Design; Research Personnel; Resources; Review Literature; Risk; Role; Safety; Science; Services; Standardization; Suicide; Suicide attempt; Suicide prevention; System; Time; Training; Training Programs; Training and Education; Veterans; Vision; Vulnerable Populations; Work; career; comparative effectiveness study; data repository; education resources; experience; improved; innovation; member; next generation; precision medicine; preventive intervention; reducing suicide; research and development; research facility; response; screening; secondary analysis; service member; social determinants; success; suicidal individual; suicidal morbidity; suicidal risk; suicide mortality; suicide rate; synergism; therapy development; timeline; tool; treatment planning

Background: The rate of death by suicide has risen by more than 30% in the past 20 years in the U.S. The rate of death by suicide among U.S. Veterans has risen even faster. Whereas Veterans only constitute 8.5% of the population, they account for 18% of all suicide deaths among U.S. adults. Although recent declines in suicide mortality among Veterans may be cause for some hopefulness, they also obscure the dynamics of suicide mortality and effectiveness of preventive interventions across vulnerable groups. Further, although we do have methods available to stratify individuals by risk level and interventions that can have positive effects in terms of reducing suicide attempts, these tools are far from perfect. There is still an urgent need to determine which available suicide prevention interventions might be the most effective for a given individual at a given time. Significance: The proposed suicide prevention clinical resource center (SP-CRC) is responsive to CSRD’s solicitation of applications from VA research facilities to establish an SP-CRC that will serve suicide prevention investigators by providing highly critical research resources to facilitate programmatic and scientific needs. The mission of our SP-CRC, the Center for Harmonizing and Improving Interventions to Prevent Suicide (CHIIPS), will be to advance a precision medicine approach to suicide prevention research. CHIIPS content area hubs will include Predictive Analytics, Biomarkers, Identification, Screening, Assessment, Social Determinants/Disparities, Interventions, and (v) Training and Education Innovation and Impact: By establishing a VA SP-CRC with an explicit focus on promoting precision medicine for suicide prevention, we will improve individual suicide prevention outcomes, address unsatisfactory response rates for standardized treatments, promote the incorporation of diverse patient presentations, characteristics, and needs into treatment plans and suicide prevention research, improve system and population-level outcomes, and increase efficient use of finite resources (staff, funds, infrastructure). Resources Delivered: At the completion of this project, we will have provided several resources to the VA suicide prevention research community including: 1) a portfolio review of VA suicide prevention research portfolio projects on precision medicine, 2) a dataset repository for use by VA suicide prevention researchers to conduct secondary analyses, 3) the establishment of precision medicine suicide prevention research postdoctoral fellowships, 4) creation and dissemination of several recommendations for clinical trials methodology and safety protocols for suicide prevention research, 5) various precision medicine related educational resources for suicide prevention researchers to promote competent precision medicine suicide prevention research, 6) a statistical and research design consultation service, 7) funding for precision medicine suicide prevention pilot studies or supplemental funding for ongoing studies, 8) a literature review of all precision medicine suicide prevention research to date. Coordination with SPRINT: CHIIPS will work closely with the Suicide Prevention Research Impact Network (SPRINT) PIs and hubs to optimize synergies and avoid duplication of effort between the two centers. Our goal is to enhance current SPRINT activities, by leveraging their network and infrastructure to focus on precision medicine approaches. Together, SPRINT and CHIIPS will help VA Office of Research and Development create a vision and set priorities for as well as build a precision medicine suicide prevention research portfolio that will advance the state of the science and help VA achieve its mission of significantly reducing the number of Veteran suicides.

背景：过去20年美国自杀死亡率上升了30%以上 美国退伍军人的自杀死亡率上升得更快。而退伍军人仅占 8.5% 就人口而言，他们占美国成年人自杀死亡人数的 18%。尽管近期有所下降 退伍军人的自杀死亡率可能会带来一些希望，但它们也掩盖了退伍军人自杀的动态 弱势群体的自杀死亡率和预防干预措施的有效性。此外，虽然我们 确实有方法可以根据风险水平对个人进行分层，并且可以采取干预措施，从而产生积极的影响 就减少自杀企图而言，这些工具远非完美。仍然迫切需要确定 哪些可用的自杀预防干预措施对于特定个人在特定时间可能是最有效的 时间。意义：拟议的自杀预防临床资源中心（SP-CRC）响应 CSRD 向 VA 研究机构征求建立 SP-CRC 服务自杀的申请 预防调查人员通过提供高度关键的研究资源来促进计划和科学 需要。我们 SP-CRC（协调和改进预防干预措施中心）的使命 自杀（CHIIPS）将推进自杀预防研究的精准医学方法。芯片 内容区域中心将包括预测分析、生物标记、识别、筛选、评估、社交 决定因素/差异、干预措施以及 (v) 培训和教育创新及影响： 建立 VA SP-CRC，明确侧重于促进预防自杀的精准医疗，我们 将改善个人自杀预防结果，解决标准化反应率不令人满意的问题 治疗，促进将不同的患者表现、特征和需求纳入 治疗计划和自杀预防研究，改善系统和人群水平的结果，并增加 有效利用有限资源（人员、资金、基础设施）。交付资源：本次任务完成时 项目中，我们将为 VA 自杀预防研究界提供多种资源，包括：1) 对 VA 精准医学自杀预防研究组合项目的组合回顾，2) 数据集 供 VA 自杀预防研究人员使用进行二次分析的存储库，3) 建立 精准医学自杀预防研究博士后奖学金，4）创建和传播 关于自杀预防研究的临床试验方法和安全方案的若干建议， 5）各种精准医学相关教育资源，供自杀预防研究人员推广 胜任的精准医学自杀预防研究，6）统计和研究设计咨询 服务，7) 为精准医学自杀预防试点研究提供资金或为正在进行的补充资金 研究，8）迄今为止所有精准医学自杀预防研究的文献综述。协调与 SPRINT：CHIIPS 将与自杀预防研究影响网络 (SPRINT) 的 PI 和 中心，以优化协同效应并避免两个中心之间的重复工作。我们的目标是增强 当前的 SPRINT 活动，通过利用其网络和基础设施专注于精准医疗 接近。 SPRINT 和 CHIIPS 将共同帮助 VA 研究与开发办公室制定愿景 确定优先事项并建立精准医学自杀预防研究组合， 推进科学发展并帮助 VA 实现显着减少 退伍军人自杀。