CSR&D Research Career Development Transition Award Application

企业社会责任

• 批准号: 10663063
• 负责人: Josh Woolley
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663063
• 关键词: Acceleration; Acute; Adherence; Affect; Agonist; Area; Award; Behavior; Behavioral; Behavioral Mechanisms; Caring; Cellular Phone; Chronic; Clinical; Clinical Trials; Cognitive; Consumption; Detection; Development; Diagnosis; Diagnostic; Disease; Doctor of Philosophy; Emotions; Epidemic; Eye; Face; Faculty; Feeling; Focus Groups; Funding; Goals; Health; Health Care Costs; Health system; Healthcare; Individual; Industry; Interdisciplinary Study; International; Intervention; K-Series Research Career Programs; Laboratories; Lead; Loneliness; Measures; Medical; Medical Students; Mental Health; Mental disorders; Mentors; Mission; Modification; Morbidity - disease rate; Motivation; Neuropeptides; Occupational; Outcome; Oxytocin; Pathologic; Pathway interactions; Patients; Performance; Personal Satisfaction; Persons; Pharmaceutical Preparations; Pharmacological Treatment; Phase; Physiological; Positioning Attribute; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Prevalence; Privatization; Productivity; Psilocybin; Psyche structure; Psychiatric therapeutic procedure; Psychophysiology; Psychoses; Psychotherapy; Quality of life; Reporting; Research; Research Assistant; Research Personnel; Schizophrenia; Scientist; Services; Severities; Short-Term Memory; Site; Social Behavior; Social Functioning; Social Processes; Social isolation; Social support; Substance Use Disorder; Suicide; Talents; Testing; Time; Training; Transition Career Development Award (K22); United States National Institutes of Health; Veterans; Work; alcohol use disorder; attentional bias; clinical application; cognitive ability; cohesion; comorbidity; cost; craving; diagnostic strategy; disability; doctoral student; economic cost; ecstasy; effective therapy; efficacy trial; gaze; graduate student; improved; member; mortality; multidisciplinary; neural; neuroimaging; neuromechanism; neurophysiology; neuropsychiatric disorder; novel; opioid use disorder; pharmacologic; physical conditioning; pre-doctoral; program costs; programs; psychologic; psychosocial; randomized, clinical trials; receptor; reduce symptoms; service utilization; side effect; smartphone application; social; social cognition; social deficits; social situation; stimulant use disorder; treatment program; uptake; volunteer

There is an “epidemic of loneliness” with 20% of civilians and up to 50% of veterans reporting feeling lonely or socially isolated. This is clinically important because loneliness and social isolation are strong predictors of worse physical health and early mortality. Mental illness is intimately entwined with this epidemic because it both causes and is worsened by loneliness and social isolation. It is the social deficits of mental illness that most strongly contribute to loneliness and social isolation. These social deficits include difficulty understanding other people’s behavior and difficulty behaving appropriately in social situations. Despite their importance, these social deficits are poorly understood at the neural and behavioral levels and are difficult to quantify. Moreover, available treatments for them are inadequate. I am the Director of the Bonding and Attunement in Neuropsychiatric Disorders (BAND) lab, which comprises one junior faculty member supported by a CSR&D Career Development Award, 5 postdoctoral fellows including MDs and PhDs, 4 graduate students, 6 paid research assistants, over 20 volunteers. We believe the key to mental health and well-being starts with strong relationships. Our mission is to develop novel pharmacological and cognitive interventions for mental illness that enable patients to strengthen their connections to other people and the world. Our work has primarily focused on understanding the psychological, behavioral, physiological, and neural effects of administration of the neuropeptide oxytocin across multiple psychiatric illnesses. For example, we have conducted numerous studies determining the acute effects of oxytocin administration in individuals with schizophrenia. One highlight of this work is that we found that a single administration of oxytocin to individuals with schizophrenia normalized neural activity during high-level social cognitive processing and that this normalization was associated with improved behavioral performance. This work led to a VA CSR&D Merit Award to conduct the largest randomized clinical trial of repeated administration of oxytocin in schizophrenia to date. We have also conducted studies investigating oxytocin as a potential treatment for individuals with alcohol, opioid, and stimulant use disorders, and co-occurring post-traumatic stress disorder (PTSD) and alcohol use disorder (a common and difficult-to-treat comorbidity). We also recently completed a large laboratory-based study in healthy individuals to determine whether acute oxytocin administration can accelerate the development of team cohesion. This work led us to hypothesize that pharmacological treatments that affect social processes could be paired with psychosocial treatments to possibly achieve synergistically positive outcomes. To investigate this possibility, we have conducted studies pairing administration of various drugs with social effects, including oxytocin, 3,4-methylenedioxy-methamphetamine (MDMA), and psilocybin, with various psychotherapy interventions including group-based psychotherapy. In the non-pharmacological arena, we have been investigating attention bias modification delivered through a smartphone app as a treatment for PTSD. Our studies incorporate multiple analytic approaches including objective measures of social behavior such as eye-gaze, facial expressivity, team cohesion and performance, quantification of social cognitive abilities, neuroimaging approaches, laboratory-based craving induction paradigms, and quantification of psychophysiological changes and interpersonal synchrony. In sum, I have developed a broad and highly productive trans-diagnostic program of research and assembled a large, energetic, and multidisciplinary research group focused on developing and testing novel treatments for the difficult to treat social deficits that cut across most psychiatric disorders. By improving social deficits across disorders, veterans will have better social functioning and decreased symptom severity and will be able to more effectively mobilize their social support networks and engage in other psychiatric treatment. This will lead to better health outcomes and decreased costs for the VA health system.

有一种“孤独流行病”，20%的平民和高达50%的退伍军人报告感到孤独或孤独

项目成果

Posttraumatic stress disorder symptoms associated with protective and risky behaviors for coronavirus disease 2019.

• DOI: 10.1037/hea0001157
• 发表时间: 2022-03
• 期刊: Health psychology : official journal of the Division of Health Psychology, American Psychological Association
• 作者: Nishimi K;Borsari B;Marx BP;Tripp P;Woodward E;Rosen RC;Cohen BE;Maven D;Jiha A;Woolley JD;Neylan TC;O'Donovan A
• 通讯作者: O'Donovan A

Risks and benefits of psilocybin use in people with bipolar disorder: An international web-based survey on experiences of 'magic mushroom' consumption.

• DOI: 10.1177/02698811221131997
• 发表时间: 2023-01
• 期刊: JOURNAL OF PSYCHOPHARMACOLOGY
• 影响因子: 4.1
• 作者: Morton, Emma;Sakai, Kimberly;Ashtari, Amir;Pleet, Mollie;Michalak, Erin E.;Woolley, Josh
• 通讯作者: Woolley, Josh

The effects of intranasal oxytocin on black participants' responses to outgroup acceptance and rejection.

• DOI: 10.3389/fpsyg.2022.916305
• 发表时间: 2022
• 期刊: FRONTIERS IN PSYCHOLOGY
• 影响因子: 3.8
• 作者: Park, Jiyoung;Woolley, Joshua;Mendes, Wendy Berry
• 通讯作者: Mendes, Wendy Berry

"A sense of the bigger picture:" A qualitative analysis of follow-up interviews with people with bipolar disorder who self-reported psilocybin use.

• DOI: 10.1371/journal.pone.0279073
• 发表时间: 2022
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: DellaCrosse, Meghan;Pleet, Mollie;Morton, Emma;Ashtari, Amir;Sakai, Kimberly;Woolley, Josh;Michalak, Erin
• 通讯作者: Michalak, Erin