Mentoring in Translational Malaria Genomics

转化疟疾基因组学指导

• 批准号: 10662964
• 负责人: Jonathan J Juliano
• 金额: $ 17.32万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-12 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10662964
• 关键词: Address; Africa; Africa South of the Sahara; Award; Biological Assay; Biology; Clinic; Clinical Sciences; Communicable Diseases; Communities; Complementarity Determining Regions; Complex; Country; Cross-Sectional Studies; Democratic Republic of the Congo; Detection; Development; Disease; Doctor of Philosophy; Educational process of instructing; Elements; Ensure; Environment; Equity; Evolution; Exclusion; Faculty; Fellowship Program; Fostering; Funding; Genes; Genetic; Genetic Markers; Genetic Variation; Genome; Genomics; Genotype; Geography; Gills; Goals; Hot Spot; Household; Infection; Instruction; International; Intervention; Knowledge; Leadership; Location; London; Malaria; Mentors; Mentorship; Methodology; Methods; Mid-Career Clinical Scientist Award (K24); Modeling; Molecular; Movement; Multigene Family; North Carolina; Parasites; Pathogenesis; Pattern; Persons; Plasmodium falciparum; Population; Positioning Attribute; Postbaccalaureate; Public Health; Publishing; Research; Research Personnel; Resistance; Resolution; Resources; Risk Factors; Rural; Sampling; Schools; Site; Structure; Students; Technology; Time; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Urbanicity; Work; Zanzibar; career; career development; college; comparative; cost effective; deep sequencing; design; doctoral student; effective intervention; experience; genome sequencing; genomic tools; improved; induced pluripotent stem cell; learning strategy; malaria infection; malaria transmission; medical schools; member; migration; next generation sequencing; patient oriented research; professor; programs; recruit; rural area; skills; targeted sequencing; tool; translational genomics; transmission process; urban setting; whole genome

PROJECT SUMMARY Dr. Jonathan Juliano is an internationally recognized leader in malaria research and a pioneer in the use of next generation sequencing technologies for applied genomics projects. He is a Professor in the Division of Infectious Diseases at the University of North Carolina at Chapel Hill, where he has helped to establish a major center for translational malaria research. He has had continuous independent NIH funding since 2010. Dr. Juliano is committed to an academic career in patient-oriented research (POR), in which he and his trainees address problems with direct relevance to malaria control, He is recognized as an outstanding mentor, having received the prestigious 2016 Distinguished Teaching Award for Post-Baccalaureate Instruction at UNG for his strong record of mentoring trainees, which focuses on Infectious Disease fellows and MD/PhD students students involved in POR The proposed renewal of his K24 award will allow Dr. Juliano to develop new research skills to enhance his research expertise and mentorship by gaining skills in spatial and transmission modeling of malaria, by learning strategies for effective leadership, and by building on the mentoring skills developed in his K24. In particular, he will newly focus on skills specifically for mentoring diverse groups of trainees through both formal and informal guidance. To foster the career development of his trainees, Dr. Juliano will leverage the extensive training resources available at UNG, including the NC Translational and Clinical Sciences Institute, the Gillings School of Global Public Health, and the School of Medicine. Dr. Juliana's involvement in these programs, as well as the School of Medicine MD/PhD program and the UNG Infectious Diseases Fellowship program, ensures that he will be well positioned to recruit and mentor trainees. The proposed CAMMM study (Comparative Analysis of Methods for Malaria Movement) will aid the malaria elimination agenda by providing a better understanding of how parasites move in space in different transmission settings, Understanding the spatial dynamics of parasite migration and transmission can help define hot spots for intervention, define importation, and inform models to predict the spread of resistance. However, to realize this goal, a better understanding of what genomic methods work in different locations and transmission intensities is needed. Combining advances in genotyping with training in spatial and transmission modeling though didactic and a mentored experience at Imperial College London will provide Dr. Juliano and his mentees the ability to strengthen their research and translate their genomic findings into actionable information. The proposed K24 will permit Dr. Juliano to develop a research platform that is a natural extension of his previous work, will result in a significant methodological advance for the study of malaria transmission, will enhance his mentoring skills to ensure an equitable environment for all trainees, and will establish new research opportunities to foster the career development and mentoring of trainees and young faculty members in POR.

项目总结 乔纳森·朱利亚诺博士是国际公认的疟疾研究领导者，也是将下一代测序技术用于应用基因组学项目的先驱。他是北卡罗来纳大学教堂山分校传染病系的教授，在那里他帮助建立了一个主要的疟疾翻译研究中心。自2010年以来，他一直获得美国国立卫生研究院的独立资助。朱利亚诺博士致力于以患者为导向的研究(POR)的学术生涯，在该研究中，他和他的学员解决与疟疾控制直接相关的问题，他被公认为一位杰出的导师，他因其在指导学员方面的出色记录而获得了著名的2016年度UNG学士学位后教学杰出教学奖，该奖项侧重于参与POR的传染病研究员和MD/博士生。拟议中的续签他的K24奖项将使胡利亚诺博士能够发展新的研究技能，通过获得疟疾空间和传播模型方面的技能，通过学习有效领导的策略，增强他的研究专长和指导，并通过建立在他的K24中培养的指导技能。特别是，他将特别注重通过正式和非正式指导来指导不同受训人员群体的技能。为了促进学员的职业发展，Juliano博士将利用UNG现有的广泛培训资源，包括北卡罗来纳州翻译和临床科学研究所、吉林斯全球公共卫生学院和医学院。Juliana博士参与了这些项目，以及医学院的MD/PhD计划和UNG传染病奖学金计划，确保他将处于招募和指导受训人员的有利地位。拟议的CAMMM研究(疟疾运动方法比较分析)将通过更好地了解寄生虫在不同传播环境下如何在空间中移动，了解寄生虫迁移和传播的空间动力学，有助于确定干预热点，定义输入，并为预测耐药性传播的模型提供信息，从而帮助消除疟疾议程。然而，为了实现这一目标，需要更好地了解什么基因组方法在不同的位置和传播强度下有效。通过授课和在伦敦帝国理工学院的指导经验，将基因分型方面的进展与空间和传播建模方面的培训结合起来，将使朱利亚诺博士和他的受训者有能力加强他们的研究，并将他们的基因组发现转化为可操作的信息。拟议的K24将允许Juliano博士开发一个研究平台，这是他以前工作的自然延伸，将导致疟疾传播研究的方法上的重大进步，将提高他的指导技能，以确保为所有受训人员提供公平的环境，并将建立新的研究机会，以促进受训人员和POR年轻教员的职业发展和指导。