Mentoring in Translational Malaria Genomics

项目摘要 博士Jonathan Juliano是国际公认的疟疾研究领导者，也是使用 应用基因组学项目的下一代测序技术。他是一名副教授， 查佩尔山的北卡罗来纳州大学传染病系，在那里他帮助 建立一个主要的疟疾转化研究中心。他有持续的独立NIH资助 自2010年Juliano博士致力于以患者为导向的研究（POR）的学术生涯，他 他和他的受训人员解决与疟疾控制直接相关的问题。最近，他收到了 著名的2016年杰出教学奖后学士学位教学中，他的强大 指导学员的记录，重点是传染病研究员和MD/博士生参与 POR。拟议的K24奖将使Juliano博士能够发展新的研究技能，以提高他的研究 获得统计遗传学和人口基因组学方面的技能， 有效领导的战略，并提高他的指导技能。拟议的研究将 创造新的研究机会，促进学员的职业发展。为了实现他的目标，博士。 Juliano将充分利用在CNAS提供的广泛培训资源，包括NC翻译和 临床科学研究所、吉林斯全球公共卫生学院和医学院。博士 Juliano参与这些项目，以及医学博士/博士项目和生物医学博士项目。 传染病奖学金计划，确保他将很好地定位招募和指导学员， 包括学生、研究员和初级教员。作为这项建议的一部分，他将收到正式和非正式的 指导，以发展为导师，也增加了他在校园正式辅导活动的参与。 Juliano博士研究的核心是了解抗疟疾药物的耐药性。抗药性的出现 疟疾寄生虫是控制恶性疟原虫的主要障碍，恶性疟原虫已经进化出对 几乎所有的抗疟疾药物都在使用。重要的是，人们对寄生虫种群如何进化 允许抵抗的出现和蔓延。统计遗传学和人口统计推断提供了一个 了解影响寄生虫传播速度和时间的寄生虫种群特征的框架 阻力这些方法提供了一个机会，可以预测耐药性传播的未来路径， 帮助制定有针对性的干预措施。抗疟药耐药性研究的人口学推断 迁移（DISARM）研究将把人类统计遗传学的进展转化为 疟疾寄生虫种群拟议中的K24将允许Juliano博士开发一个研究平台， 他以前的工作的自然延伸，代表了一个重要的方法论进步的研究， 该项目为培训生和年轻教员提供了大量直接指导的机会。

PROJECT SUMMARY Dr. Jonathan Juliano is an internationally recognized leader in malaria research and a pioneer in the use of next generation sequencing technologies for applied genomics projects. He is an Associate Professor in the Division of Infectious Diseases at the University of North Carolina at Chapel Hill, where he has helped to establish a major center for translational malaria research. He has had continuous independent NIH funding since 2010. Dr. Juliano is committed to an academic career in patient-oriented research (POR), in which he and his trainees address problems with direct relevance to malaria control. Recently, he received the prestigious 2016 Distinguished Teaching Award for Post-Baccalaureate Instruction at UNC for his strong record of mentoring trainees, which focuses on Infectious Disease fellows and MD/PhD students involed in POR. The proposed K24 award will allow Dr. Juliano to develop new research skills to enhance his research expertise and mentorship by gaining skills in statistical genetics and population genomics, by learning strategies for effective leadership, and by enhancing his mentoring skills. The proposed research will establish new research opportunities to foster the career development of his trainees. To achieve his goals, Dr. Juliano will leverage the extensive training resources available at UNC, including the NC Translational and Clinical Sciences Institute, the Gillings School of Global Public Health, and the School of Medicine. Dr. Juliano’s involvement in these programs, as well as the School of Medicine MD/PhD program and the UNC Infectious Diseases Fellowship program, ensures that he will be well positioned to recruit and mentor trainees, including students, fellows and junior faculty. As part of this proposal, he will receive both formal and informal guidance to develop as a mentor and also increase his participation in formal mentoring activities on campus. Central to Dr. Juliano’s research is understanding antimalarial resistance. The emergence of drug-resistant malaria parasites is a major hurdle in the control of Plasmodium falciparum, which has evolved resistance to nearly every antimalarial drug in use. Importantly, little is known about how parasite populations evolve to permit the emergence and spread of resistance. Statistical genetics and demographic inference provide a framework for understanding parasite population characteristics that impact the rate and timing of the spread of resistance. These approaches provide an opportunity to predict future paths for the spread of resistance and to help develop targeted interventions. The Demographic Inference to Study Antimalarial Resistance Migration (DISARM) study will translate advances made in statistical genetics for humans to the study of malaria parasite populations. The proposed K24 will permit Dr. Juliano to develop a research platform that is a natural extension of his previous work, represents a significant methodological advance for the study of malaria, and provides rich opportunities for direct mentorship of trainees and young faculty members.