Mentoring in Translational Malaria Genomics
转化疟疾基因组学指导
基本信息
- 批准号:10077822
- 负责人:
- 金额:$ 17.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-01-12 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdmixtureAfricaAfricanAnti-malarial drug resistanceAntimalarialsAreaArtemisininsAsiaAsiansAwardBacteriaBayesian AnalysisBiologyChloroquineCholeraClinical SciencesCombined Modality TherapyCommunicable DiseasesComplexContainmentCulicidaeDataDemocratic Republic of the CongoDemographic and Health SurveysDevelopmentDihydropteroate SynthaseDoctor of PhilosophyDrug resistanceEducational process of instructingEffectivenessEnsureFacultyFellowship ProgramFosteringFundingFutureGenesGeneticGenetic RecombinationGenomeGenomicsGenotypeGeographyGillsGoalsHumanHuman GeneticsInfluenzaInstitutesInstructionInternationalInterventionKnowledgeLeadershipLife Cycle StagesMalariaMeasuresMentorsMentorshipMethodologyMethodsMid-Career Clinical Scientist Award (K24)Molecular EpidemiologyMosaicismNatural experimentNorth CarolinaParasite resistanceParasitesPatternPharmaceutical PreparationsPhylogenetic AnalysisPlasmodiumPlasmodium falciparumPopulationPopulation CharacteristicsPopulation SizesPositioning AttributePublic Health SchoolsPublishingRecording of previous eventsResearchResearch PersonnelResearch Project GrantsResistanceResourcesSchoolsSideSoutheastern AsiaStructureStudentsSulfadoxineSurfaceTechnologyTrainingTranslatingTranslational ResearchTuberculosisUnited States National Institutes of HealthUniversitiesViralVirusWorkcareercareer developmentdata repositorydesigndoctoral studenteffective interventionepidemiology studyethnic diversitygenome sequencingglobal healthhuman genomicsimprovedinsightinterestlearning strategymedical schoolsmembermid-career facultymigrationnext generation sequencingpathogenic bacteriapathogenic viruspatient oriented researchpreventprogramsrecruitresistance generesistant Plasmodium falciparumresistant strainskillstooltranslational genomicswhole genome
项目摘要
PROJECT SUMMARY
Dr. Jonathan Juliano is an internationally recognized leader in malaria research and a pioneer in the use of
next generation sequencing technologies for applied genomics projects. He is an Associate Professor in the
Division of Infectious Diseases at the University of North Carolina at Chapel Hill, where he has helped to
establish a major center for translational malaria research. He has had continuous independent NIH funding
since 2010. Dr. Juliano is committed to an academic career in patient-oriented research (POR), in which he
and his trainees address problems with direct relevance to malaria control. Recently, he received the
prestigious 2016 Distinguished Teaching Award for Post-Baccalaureate Instruction at UNC for his strong
record of mentoring trainees, which focuses on Infectious Disease fellows and MD/PhD students involed in
POR. The proposed K24 award will allow Dr. Juliano to develop new research skills to enhance his research
expertise and mentorship by gaining skills in statistical genetics and population genomics, by learning
strategies for effective leadership, and by enhancing his mentoring skills. The proposed research will
establish new research opportunities to foster the career development of his trainees. To achieve his goals, Dr.
Juliano will leverage the extensive training resources available at UNC, including the NC Translational and
Clinical Sciences Institute, the Gillings School of Global Public Health, and the School of Medicine. Dr.
Juliano’s involvement in these programs, as well as the School of Medicine MD/PhD program and the UNC
Infectious Diseases Fellowship program, ensures that he will be well positioned to recruit and mentor trainees,
including students, fellows and junior faculty. As part of this proposal, he will receive both formal and informal
guidance to develop as a mentor and also increase his participation in formal mentoring activities on campus.
Central to Dr. Juliano’s research is understanding antimalarial resistance. The emergence of drug-resistant
malaria parasites is a major hurdle in the control of Plasmodium falciparum, which has evolved resistance to
nearly every antimalarial drug in use. Importantly, little is known about how parasite populations evolve to
permit the emergence and spread of resistance. Statistical genetics and demographic inference provide a
framework for understanding parasite population characteristics that impact the rate and timing of the spread of
resistance. These approaches provide an opportunity to predict future paths for the spread of resistance and to
help develop targeted interventions. The Demographic Inference to Study Antimalarial Resistance
Migration (DISARM) study will translate advances made in statistical genetics for humans to the study of
malaria parasite populations. The proposed K24 will permit Dr. Juliano to develop a research platform that is a
natural extension of his previous work, represents a significant methodological advance for the study of
malaria, and provides rich opportunities for direct mentorship of trainees and young faculty members.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jonathan J Juliano其他文献
Clinical and genomic diversity of emTreponema pallidum/em subspecies empallidum/em to inform vaccine research: an international, molecular epidemiology study
苍白密螺旋体亚种苍白亚种的临床和基因组多样性,以指导疫苗研究:一项国际分子流行病学研究
- DOI:
10.1016/s2666-5247(24)00087-9 - 发表时间:
2024-09-01 - 期刊:
- 影响因子:20.400
- 作者:
Arlene C Seña;Mitch M Matoga;Ligang Yang;Eduardo Lopez-Medina;Farhang Aghakhanian;Jane S Chen;Everton B Bettin;Melissa J Caimano;Wentao Chen;Jonny A Garcia-Luna;Christopher M Hennelly;Edward Jere;Yinbo Jiang;Jonathan J Juliano;Petra Pospíšilová;Lady Ramirez;David Šmajs;Joseph D Tucker;Fabio Vargas Cely;Heping Zheng;Jonathan B Parr - 通讯作者:
Jonathan B Parr
Association between domesticated animal ownership and emPlasmodium falciparum/em parasite prevalence in the Democratic Republic of the Congo: a national cross-sectional study
刚果民主共和国家养动物所有权与恶性疟原虫寄生虫流行率之间的关联:一项全国横断面研究
- DOI:
10.1016/s2666-5247(23)00109-x - 发表时间:
2023-07-01 - 期刊:
- 影响因子:20.400
- 作者:
Camille E Morgan;Hillary M Topazian;Katerina Brandt;Cedar Mitchell;Melchior Mwandagalirwa Kashamuka;Jérémie Muwonga;Eric Sompwe;Jonathan J Juliano;Thierry Bobanga;Antoinette Tshefu;Michael Emch;Jonathan B Parr - 通讯作者:
Jonathan B Parr
Jonathan J Juliano的其他文献
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{{ truncateString('Jonathan J Juliano', 18)}}的其他基金
Importation and transmission of malaria in Zanzibar: a case study for elimination
桑给巴尔疟疾的输入和传播:消除疟疾的案例研究
- 批准号:
10458051 - 财政年份:2021
- 资助金额:
$ 17.45万 - 项目类别:
Importation and transmission of malaria in Zanzibar: a case study for elimination
桑给巴尔疟疾的输入和传播:消除疟疾的案例研究
- 批准号:
10669022 - 财政年份:2021
- 资助金额:
$ 17.45万 - 项目类别:
Importation and transmission of malaria in Zanzibar: a case study for elimination
桑给巴尔疟疾的输入和传播:消除疟疾的案例研究
- 批准号:
10296505 - 财政年份:2021
- 资助金额:
$ 17.45万 - 项目类别:
Collaborative Research: Impacts of the African Origin of Plasmodium vivax on Contemporary Parasite Populations
合作研究:非洲起源的间日疟原虫对当代寄生虫种群的影响
- 批准号:
9899345 - 财政年份:2017
- 资助金额:
$ 17.45万 - 项目类别:
Diversity and Phenotype of Artemisinin Resistance Mutations in Central Africa
中部非洲青蒿素耐药突变的多样性和表型
- 批准号:
9301336 - 财政年份:2016
- 资助金额:
$ 17.45万 - 项目类别:
Variation in Resistance and Fitness to Artemisinins in African Malaria
非洲疟疾对青蒿素的耐药性和适应性的变化
- 批准号:
9010406 - 财政年份:2015
- 资助金额:
$ 17.45万 - 项目类别:
Dissecting Chloroquine Resistance in the Plasmodium vivax Cross
剖析间日疟原虫交叉中的氯喹耐药性
- 批准号:
8682061 - 财政年份:2014
- 资助金额:
$ 17.45万 - 项目类别:
Effects of Daily Cotrimoxazole on Malaria in HIV Exposed, Uninfected Infants
每日服用复方新诺明对暴露于 HIV 的未感染婴儿的疟疾的影响
- 批准号:
8653934 - 财政年份:2013
- 资助金额:
$ 17.45万 - 项目类别:
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