Annual Vitamin D Workshops

维生素D研讨会是一个非营利性的教育组织（est。其使命是组织 关于维生素D的代谢、生物功能和健康影响的科学会议。R13的目标是 资助申请，以支持2021-2025年的一系列年度维生素D研讨会。迄今为止， 22个非常成功的国际维生素D研讨会，通常吸引了200-300名基本 来自地球仪的研究人员、转化科学家、临床医生和政策制定者。维生素D是 一种活性类固醇激素的前体，可激活核受体（维生素D受体，或VDR）， 调节基因表达。它的传统作用是调节骨、肾和肠中细胞的生物学 来控制钙和骨代谢维生素D可以通过饮食和补充剂作为维生素获得 D2和D3以及维生素D3也可以在暴露于紫外线时在皮肤中合成。无论是皮肤生产 维生素D和控制钙代谢的分子作用受到衰老的抑制。许多研究 维生素D状态与多种生理和年龄相关的病理过程相关，例如 癌症、糖尿病、多发性硬化症和炎症性肠病。虽然这项研究已经产生了 大量的媒体关注，也导致了许多关于维生素分子作用的新问题 D激素，评估维生素D状态的挑战和预防慢性疾病的最佳摄入量。它 目前尚不清楚年龄、种族和遗传学如何影响维生素D的作用，以及维生素D的需求如何改变。 不同的人群。这些问题引起了科学家、卫生专业人员和公众的极大兴趣。 总的来说，这些因素证明了维生素D科学家年度会议的必要性， 资源，讨论新兴的基础和应用数据，并带来争议的领域光。 维生素D研讨会的具体目标是： 1.举办一系列关于维生素D的生物学和健康相关应用的科学会议， 地址： ·最新的同行评审的科学研究，关于生产，代谢和机制的 维生素D的作用，因为它们与生理状态和年龄有关。 ·关注全球各年龄组的维生素D缺乏症，以及如何最好地识别，治疗 并在不同人群和年龄组中预防这种情况。 ·关于个人维生素D摄入和补充的充足和安全水平的证据 在整个生命过程中，以及在那些与年龄有关的各种慢性疾病状态。 ·研究维生素D的最先进的研究方法。 2.汇集了来自学术界、医学界、工业界、政府和 在科学地检查维生素D对健康的影响方面有共同兴趣的基层组织。 3.鼓励和承认早期阶段，少数民族和弱势调查人员进行研究， 维生素D，并通过提供奖学金、旅行 赠款和青年研究员奖。 4.通过出版会议记录传播研讨会的成果。

The Vitamin D Workshop is a non-profit educational organization (est. 1977) whose mission is to organize scientific meetings on the metabolism, biological functions, and health effects of vitamin D. The goal of this R13 grant application to support a series of annual Vitamin D Workshops from 2021-2025. To date there have been 22 highly successful international Vitamin D Workshops which have typically attracted 200-300 basic researchers, translational scientists, clinicians, and policy makers from around the globe. Vitamin D is the precursor for an active steroid hormone that activates a nuclear receptor (the Vitamin D receptor, or VDR) to regulate gene expression. Its traditional role is to regulate the biology of cells in the bone, kidney, and intestine to control calcium and bone metabolism. Vitamin D can be obtained through diet and supplements as vitamins D2 and D3, and vitamin D3 can also be synthesized in skin upon exposure to UV light. Both the skin production of vitamin D and the molecular actions controlling calcium metabolism are suppressed by aging. Many studies have associated vitamin D status with a wide variety of physiologic and age-related, pathologic processes, e.g. cancer, diabetes, multiple sclerosis, and inflammatory bowel disease. While this research has generated considerable media attention, it has also led to many new questions about the molecular actions of the vitamin D hormone, the challenges of assessing vitamin D status and the optimal intake to prevent chronic diseases. It is not clear how aging, ethnicity and genetics influence vitamin D actions, and how requirements are altered in diverse populations. These issues are of great interest to scientists, health professionals and the general public. Collectively, these factors justify an annual meeting of vitamin D scientists to share research ideas and resources, discuss the emerging basic and applied data, and bring areas of controversy to light. The Specific Aims of the Vitamin D Workshops are: 1. To conduct a series of scientific conferences on the biology and health-relevant applications of vitamin D that address: • The latest peer-reviewed scientific research regarding the production, metabolism and mechanisms of action of vitamin D as they relate to physiologic state and age. • The concern of worldwide vitamin D deficiency across age groups as well as how to best identify, treat and prevent this condition in different populations and age groups. • The evidence on the adequate and safe levels of vitamin D intake and supplementation for individuals throughout the life course and in those with various age-related chronic disease states. • State of the art research approaches for studying vitamin D. 2. To bring together an interdisciplinary group of scientists from academia, medicine, industry, government and grassroots organizations with common interests in scientifically examining the health effects of vitamin D. 3. To encourage and recognize early-stage, minority and disadvantaged investigators conducting research on vitamin D and facilitate their interactions with established investigators through provision of scholarships, travel grants and young investigator awards. 4. To disseminate outcomes of the workshop through publication of the Conference Proceedings.