Deconstructing the cellular control of hippocampal functions related to mental health: a role for birth order.
解构与心理健康相关的海马功能的细胞控制:出生顺序的作用。
基本信息
- 批准号:10540772
- 负责人:
- 金额:$ 58.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-01 至 2024-11-30
- 项目状态:已结题
- 来源:
- 关键词:AblationAdolescentAdrenal GlandsAdultAlzheimer&aposs DiseaseAmericanAnesthesia proceduresAnimalsAntidepressive AgentsAnxietyBehaviorBehavioralBiologyBirthBirth OrderBrainCell LineageCell physiologyCellsChronic stressComplexDate of birthDevelopmentDiseaseDistalDorsalEnvironmental ExposureExerciseExhibitsExposure toFunctional disorderGeneticGlial Fibrillary Acidic ProteinGlucocorticoid ReceptorGlucocorticoidsHilarHippocampusHormonesHumanHypoxemiaInfectionInjuryLearningLifeLinkLogicMemoryMental DepressionMental HealthMental disordersMineralocorticoid ReceptorModelingMusMutationNeonatalNeuronsOutcomeParahippocampal GyrusPathologyPerformancePharmacogeneticsPhenotypePhysiologicalPhysiologyPopulationPredispositionProcessPsychosocial StressRabies virusRegulationResearch PersonnelRodentRoleSchizophreniaSeriesSliceStressStructureSupporting CellSynapsesSystemTechniquesTestingThinkingToxicant exposureTraumaWorkacute stressadult neurogenesisadult stem cellbehavioral responsebiological adaptation to stresscellular targetingcohortdentate gyrusdepressive behaviordesigndrug of abuseenvironmental changeenvironmental enrichment for laboratory animalsexperienceexperimental studygenetic approachhormone regulationimprovedinterestnerve stem cellneuralneurogenesisneuropsychiatric disorderoptogeneticsperiadolescentpostnatalpostnatal developmentresilienceresponsesensorspatial memorystem cell proliferationstem cellsstress resilience
项目摘要
The hippocampus has been implicated in the biology of stress as both a stress sensor and a regulator
of the stress response. It exhibits the brain's highest concentration of glucocorticoid and mineralocorticoid
receptors, as well as extensive structural and physiological plasticity in response to chronic stress exposure7.
The hippocampus is also involved in encoding context, learning and memory, and has been repeatedly
implicated in performance on depression and anxiety-related tasks in rodents and humans. Hence, it is no
surprise that hippocampal pathology has been attributed to a wide range of psychiatric diseases like
Schizophrenia, depression, anxiety, and Alzheimer's disease.
Within the hippocampus, a postnatal neural stem cell system is exquisitely sensitive to environmental
changes including stressful and enriching experiences. Exposure to chronic stress decreases neurogenesis
and increases the proliferation of stem cells, while exposure to environmental enrichment, exercise, and
antidepressants increases neurogenesis without impacting stem cells. While hippocampal neurogenesis is
highly sensitive to environmental manipulations, the resulting neurons are thought to contribute to all of the
hippocampal functions described above including stress regulation. Thus, neurons that support diverse
functions are born continuously throughout postnatal development and this process of neurogenesis is
sensitive to stress and to other environmental changes.
We are interested in unraveling the cellular logic supporting the functional repertoire of the hippocampal
dentate gyrus. Studies outlined in this proposal aim to identify cells within the dentate gyrus of the
hippocampus that are important for each of the hippocampal functions. We will use a series of state of the art
genetic approaches for targeting discrete populations of dentate gyrus neurons as they would be by stress
during development and then examine how each population of cells contributes to normal hippocampal
functioning and circuitry. Completing the proposed studies will help decipher which hippocampal neurons
contribute to encoding stress responses and determine whether the same or different cells support other
hippocampal functions.
海马体在压力的生物学中被认为既是压力传感器又是压力调节器
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
RbAp48 Protein Is a Critical Component of GPR158/OCN Signaling and Ameliorates Age-Related Memory Loss.
- DOI:10.1016/j.celrep.2018.09.077
- 发表时间:2018-10-23
- 期刊:
- 影响因子:8.8
- 作者:Kosmidis S;Polyzos A;Harvey L;Youssef M;Denny CA;Dranovsky A;Kandel ER
- 通讯作者:Kandel ER
Ablation of proliferating neural stem cells during early life is sufficient to reduce adult hippocampal neurogenesis.
- DOI:10.1002/hipo.22962
- 发表时间:2018-08
- 期刊:
- 影响因子:3.5
- 作者:Youssef M;Krish VS;Kirshenbaum GS;Atsak P;Lass TJ;Lieberman SR;Leonardo ED;Dranovsky A
- 通讯作者:Dranovsky A
Inhibition of norepinephrine signaling during a sensitive period disrupts locus coeruleus circuitry and emotional behaviors in adulthood.
- DOI:10.1038/s41598-023-29175-x
- 发表时间:2023-02-22
- 期刊:
- 影响因子:4.6
- 作者:
- 通讯作者:
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ALEX DRANOVSKY其他文献
ALEX DRANOVSKY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ALEX DRANOVSKY', 18)}}的其他基金
Deconstructing the cellular control of hippocampal functions related to mental health: a role for birth order.
解构与心理健康相关的海马功能的细胞控制:出生顺序的作用。
- 批准号:
10322677 - 财政年份:2019
- 资助金额:
$ 58.02万 - 项目类别:
Deconstructing the cellular control of hippocampal functions related to mental health: a role for birth order.
解构与心理健康相关的海马功能的细胞控制:出生顺序的作用。
- 批准号:
10056224 - 财政年份:2019
- 资助金额:
$ 58.02万 - 项目类别:
Mechanisms and Significance of Stem Cell Fate Plasticity in the Adult Hippocampus
成体海马干细胞命运可塑性的机制及意义
- 批准号:
8600315 - 财政年份:2010
- 资助金额:
$ 58.02万 - 项目类别:
Mechanisms and Significance of Stem Cell Fate Plasticity in the Adult Hippocampus
成体海马干细胞命运可塑性的机制及意义
- 批准号:
8004856 - 财政年份:2010
- 资助金额:
$ 58.02万 - 项目类别:
Mechanisms and Significance of Stem Cell Fate Plasticity in the Adult Hippocampus
成体海马干细胞命运可塑性的机制及意义
- 批准号:
8115042 - 财政年份:2010
- 资助金额:
$ 58.02万 - 项目类别:
Mechanisms and Significance of Stem Cell Fate Plasticity in the Adult Hippocampus
成体海马干细胞命运可塑性的机制及意义
- 批准号:
8449454 - 财政年份:2010
- 资助金额:
$ 58.02万 - 项目类别:
Mechanisms and Significance of Stem Cell Fate Plasticity in the Adult Hippocampus
成体海马干细胞命运可塑性的机制及意义
- 批准号:
8246525 - 财政年份:2010
- 资助金额:
$ 58.02万 - 项目类别:
The contribution of adult-born neurons to hippocampal structure and connectivity.
成年神经元对海马结构和连接的贡献。
- 批准号:
7929292 - 财政年份:2009
- 资助金额:
$ 58.02万 - 项目类别:
The contribution of adult-born neurons to hippocampal structure and connectivity.
成年神经元对海马结构和连接的贡献。
- 批准号:
7339810 - 财政年份:2007
- 资助金额:
$ 58.02万 - 项目类别:
相似海外基金
Exploring the mental health and wellbeing of adolescent parent families affected by HIV in South Africa
探讨南非受艾滋病毒影响的青少年父母家庭的心理健康和福祉
- 批准号:
ES/Y00860X/1 - 财政年份:2024
- 资助金额:
$ 58.02万 - 项目类别:
Fellowship
Scaling-up co-designed adolescent mental health interventions
扩大共同设计的青少年心理健康干预措施
- 批准号:
MR/Y020286/1 - 财政年份:2024
- 资助金额:
$ 58.02万 - 项目类别:
Fellowship
Shared Spaces: The How, When, and Why of Adolescent Intergroup Interactions
共享空间:青少年群体间互动的方式、时间和原因
- 批准号:
ES/T014709/2 - 财政年份:2024
- 资助金额:
$ 58.02万 - 项目类别:
Research Grant
Social Media Mechanisms Affecting Adolescent Mental Health (SoMe3)
影响青少年心理健康的社交媒体机制 (SoMe3)
- 批准号:
MR/X034925/1 - 财政年份:2024
- 资助金额:
$ 58.02万 - 项目类别:
Fellowship
Parent-adolescent informant discrepancies: Predicting suicide risk and treatment outcomes
父母与青少年信息差异:预测自杀风险和治疗结果
- 批准号:
10751263 - 财政年份:2024
- 资助金额:
$ 58.02万 - 项目类别:
Adolescent sugar overconsumption programs food choices via altered dopamine signalling
青少年糖过度消费通过改变多巴胺信号来影响食物选择
- 批准号:
BB/Y006496/1 - 财政年份:2024
- 资助金额:
$ 58.02万 - 项目类别:
Research Grant
The Impact of Online Social Interactions on Adolescent Cognition
在线社交互动对青少年认知的影响
- 批准号:
DE240101039 - 财政年份:2024
- 资助金额:
$ 58.02万 - 项目类别:
Discovery Early Career Researcher Award
Resilience Factors, Pain, and Physical Activity in Adolescent Chronic Musculoskeletal Pain
青少年慢性肌肉骨骼疼痛的弹性因素、疼痛和体力活动
- 批准号:
10984668 - 财政年份:2024
- 资助金额:
$ 58.02万 - 项目类别:
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 58.02万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Evaluating the impact of changes in the proximity and density of vape retailers around secondary schools in Ontario on adolescent vaping behaviours
评估安大略省中学周围电子烟零售商的距离和密度变化对青少年电子烟行为的影响
- 批准号:
500515 - 财政年份:2023
- 资助金额:
$ 58.02万 - 项目类别:
Operating Grants














{{item.name}}会员




