Fear Entrainment of Circadian Rhythms

昼夜节律的恐惧夹带

基本信息

  • 批准号:
    10539261
  • 负责人:
  • 金额:
    $ 33.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-12-01 至 2023-11-30
  • 项目状态:
    已结题

项目摘要

SUMMARY Recent work in our laboratory has shown that cyclic fear can prevail over entrainment of circadian rhythms by the light-dark (LD) cycle and lead to diurnal foraging and feeding in nocturnal rodents. When mice or rats are housed in a cage setup in which they need to leave a safe nesting area to access a foraging area for food and water, they forage and feed during the dark phase of the LD cycle. If the foraging area is rendered dangerous with random footshocks during the active dark phase, the animals’ foraging and feeding activity shifts to the light phase. This switch to diurnal behavior represents the output of a circadian oscillator, which is entrained by the cyclic fear stimulus, and is dependent on an intact suprachiasmatic nucleus (SCN), where the master clock resides, and an intact amygdala, which encodes fear perception. Our working hypothesis for this proposal is that a circadian oscillator within the amygdala is entrained by cyclic fear and leads to a shift in the timing of foraging and feeding behavior. Specific Aim 1 will determine whether cyclic nocturnal fear entrains the circadian oscillators in the amygdala and/or the SCN in animals entrained to cyclic fear under LD or constant darkness (DD) conditions. Specific Aim 2 will determine whether cyclic fear can also entrain the circadian rhythms of foraging and feeding in female mice, and whether sex differences are explained by the ovarian hormone regulation. Specific Aim 3 will determine whether the evocation of fear by electrical or optogenetic stimulation of the basolateral amygdala (BLA) during the dark phase is sufficient to induce entrainment of feeding and foraging, and whether the activation of the BLA is necessary for fear entrainment by optogenetically inhibiting it while animals are exposed to the fear stimulus. This Aim will also assess whether in vitro optogenetic stimulation of the amygdala is sufficient to locally entrain the amygdala circadian oscillator. Specific Aim 4A,B will exploit region-specific KOs of the clock gene Bmal1 or global KOs of the clock genes Per1 and Per2 to determine whether canonical molecular clock of mammals is part of the fear-entrained oscillator. Aim 4C will assess whether amygdala-specific Bmal1 KOS fail to entrain to cyclic fear. Our finding that nocturnal fear entrains circadian rhythms indicates that limbic centers that encode fear are part of the circuitry that orchestrates circadian rhythms. It also provides a uniquely tractable system to unmask how the master circadian clock within the SCN and the amygdala integrate photic and fear cues to time complex behavioral processes. Circadian and sleep disorders are a hallmark of anxiety and fear disorders such as post- traumatic stress disorder; our findings could shed light into the neural mechanisms that link trauma to the regulation of sleep and circadian rhythms.
总结

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sleep and the circadian system: The latest gossip on a tumultuous long-term relationship.
Sleep timing and the circadian clock in mammals: Past, present and the road ahead.
睡眠时间和哺乳动物的昼夜节律:过去,现在和前进的道路。
  • DOI:
    10.1016/j.semcdb.2021.05.034
  • 发表时间:
    2022-06
  • 期刊:
  • 影响因子:
    7.3
  • 作者:
    Sanchez REA;Kalume F;de la Iglesia HO
  • 通讯作者:
    de la Iglesia HO
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Horacio O De La Iglesia其他文献

Horacio O De La Iglesia的其他文献

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{{ truncateString('Horacio O De La Iglesia', 18)}}的其他基金

Regulation of Circadian Rhythms and Sleep by The Lunar Month
农历月份对昼夜节律和睡眠的调节
  • 批准号:
    10514347
  • 财政年份:
    2022
  • 资助金额:
    $ 33.1万
  • 项目类别:
Circadian Structural Plasticity in Central Pacemakers
中央起搏器的昼夜节律结构可塑性
  • 批准号:
    10287332
  • 财政年份:
    2021
  • 资助金额:
    $ 33.1万
  • 项目类别:
Fear Entrainment of Circadian Rhythms
昼夜节律的恐惧夹带
  • 批准号:
    10311536
  • 财政年份:
    2018
  • 资助金额:
    $ 33.1万
  • 项目类别:
Fear Entrainment of Circadian Rhythms
昼夜节律的恐惧夹带
  • 批准号:
    10531752
  • 财政年份:
    2018
  • 资助金额:
    $ 33.1万
  • 项目类别:
The Society for Research on Biological Rhythms Conference: The Implications of Biological Rhythms for Health and Society
生物节律研究学会会议:生物节律对健康和社会的影响
  • 批准号:
    9543207
  • 财政年份:
    2018
  • 资助金额:
    $ 33.1万
  • 项目类别:
Fear Entrainment of Circadian Rhythms
昼夜节律的恐惧夹带
  • 批准号:
    10057402
  • 财政年份:
    2018
  • 资助金额:
    $ 33.1万
  • 项目类别:
Role of GABA on circadian and homeostatic regulation of sleep
GABA 对昼夜节律和睡眠稳态调节的作用
  • 批准号:
    9128731
  • 财政年份:
    2015
  • 资助金额:
    $ 33.1万
  • 项目类别:
Role of GABA on circadian and homeostatic regulation of sleep
GABA 对昼夜节律和睡眠稳态调节的作用
  • 批准号:
    9004847
  • 财政年份:
    2015
  • 资助金额:
    $ 33.1万
  • 项目类别:
Upstream Regulation of Kiss1 Cells
Kiss1 细胞的上游调控
  • 批准号:
    7988587
  • 财政年份:
    2010
  • 资助金额:
    $ 33.1万
  • 项目类别:
Communication in the Mammalian Circadian Clock: The Role of Nitric Oxide
哺乳动物昼夜节律钟中的通讯:一氧化氮的作用
  • 批准号:
    8011525
  • 财政年份:
    2009
  • 资助金额:
    $ 33.1万
  • 项目类别:
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