Regulation of Circadian Rhythms and Sleep by The Lunar Month

农历月份对昼夜节律和睡眠的调节

• 批准号: 10514347
• 负责人: Horacio O De La Iglesia
• 金额: $ 56.95万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-25 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10514347
• 关键词: Address; Affect; Argentina; Body Temperature; Circadian Rhythms; Communities; Data; Disease; Elderly; Electricity; Environment; Event; Evolution; Geography; Goals; Gold; Habitats; Health; Human; Hydrocortisone; Impairment; Individual; Industrialization; Laboratories; Lead; Life; Light; Measures; Melatonin; Moon; Moon Cycle; Moon Phases; Participant; Pattern; Perception; Persons; Phase; Plasma; Pollution; Polysomnography; Population; Process; Protocols documentation; Psyche structure; Publishing; Recording of previous events; Recovery; Regulation; Rural; Sleep; Sleep Deprivation; Sleep disturbances; Societies; System; Testing; Time; Urban Community; Urbanization; Variant; Visit; Wakefulness; Work; awake; base; circadian; circadian pacemaker; circadian regulation; indigenous community; light intensity; pressure; rural area; sleep onset; sleep pattern; sleep regulation; sleep regulatory center; university student; urban area; urban setting; young adult

PROJECT SUMMARY Throughout evolution and history humans have progressively isolated themselves from the natural cycles by building artificial habitats that shield them from the external environment. This has vastly affected when and how much humans sleep, especially since the near universalization of electric light. The key to this isolation and change in sleep patterns is the ability to manipulate artificial light and extend activity into the nighttime. A recent study from our laboratory found that the timing of sleep changes across the moon cycle, with later and shorter events of night sleep on the nights leading up to the full moon. Surprisingly, we found this lunar cycle modulation not only in rural but also in urban environments. Sleep is controlled by two simultaneous processes: the circadian clock determines the optimal times for sleep throughout the 24-h cycle while the homeostatic drive for sleep increases as we stay awake. The two processes combine to determine the natural human patterns of night sleep. This project aims to determine which of these two mechanisms that regulate sleep is affected throughout the moon cycle to delay and shorten sleep on the nights before full moon. We will combine longitudinal field recordings of sleep and sleep laboratory strategies to address the following two aims: Specific Aim 1: Assess circadian phase at opposite phases of the moon cycle in Toba/Qom communities. We will conduct longitudinal monitoring of sleep in rural and urban native Toba/Qom communities in northern Argentina. In individuals with robust lunar patterns we will assess the phase of the dim-light melatonin onset (DLMO), the gold- standard for determining circadian phase in humans, in the days leading to the full and new moons. Our hypothesis is that the phase of the circadian clock is modulated across the moon cycle, and predicts that the DLMO phase will be delayed on the days preceding the full moon relative to the pre-new moon days. Specific Aim 2: Assess circadian phase, and circadian and homeostatic regulation of sleep at opposite phases of the moon cycle in a highly urbanized community. We have already confirmed that this lunar modulation is present even in industrialized societies, where artificial light during the evening reigns over the full moon’s light. We will screen Seattle participants through longitudinal sleep monitoring and select those with the most robust lunar rhythms to participate in sleep laboratory visits twice at the opposite phases of the moon cycle. We will use polysomnographic wake and sleep recordings, as well as a constant routine protocol to study the potential lunar monthly change in circadian phase and in the homeostatic regulation of sleep after sleep deprivation. Whether the moon can affect sleep has been a matter of high controversy for decades. Our recent work demonstrated that sleep patterns vary across the moon cycle in a very predictable manner in real life conditions, in very different populations and under different environments. This project aims to shed light on the mechanisms through which this modulation occurs, which will further our understanding of the regulation of human sleep, and its impact on health and disease.

项目概要 在整个进化和历史中，人类通过建造建筑逐渐将自己与自然循环隔离开来。 人工栖息地保护它们免受外部环境的影响。这极大地影响了人类何时以及有多少 睡眠，尤其是自从电灯接近普及以来。这种隔离和睡眠模式改变的关键是 操纵人造光并将活动延长至夜间的能力。我们实验室最近的一项研究发现 睡眠时间在月亮周期中会发生变化，导致夜间睡眠时间变晚且变短 直到满月。令人惊讶的是，我们不仅在农村而且在城市环境中发现了这种月球周期调制。 睡眠由两个同时发生的过程控制：生物钟决定最佳睡眠时间 在整个 24 小时周期中，当我们保持清醒时，睡眠的稳态驱动力会增加。两个过程结合起来 确定人类夜间睡眠的自然模式。该项目旨在确定这两个中的哪一个 调节睡眠的机制在整个月亮周期中都会受到影响，从而延迟和缩短夜间的睡眠 满月之前。我们将结合睡眠的纵向现场记录和睡眠实验室策略来解决 以下两个目标： 具体目标 1：评估多巴/库姆社区月亮周期相反阶段的昼夜节律相位。我们将 对阿根廷北部农村和城市托巴/库姆社区的睡眠进行纵向监测。在 对于具有强大月球模式的个体，我们将评估弱光褪黑激素发作（DLMO）的阶段，即黄金- 确定人类昼夜节律阶段的标准，即满月和新月之前的日子。我们的假设是 生物钟的相位在整个月球周期中受到调节，并预测 DLMO 相位将是 相对于新月前的日子，满月前的日子延迟。 具体目标 2：评估昼夜节律阶段以及相反阶段睡眠的昼夜节律和稳态调节 高度城市化社区的月亮周期。我们已经证实，这种月球调制甚至存在于 在工业化社会，晚上的人造光统治着满月的光。我们将筛选西雅图 通过纵向睡眠监测来选择参与者，并选择那些月球节律最强劲的参与者参与 睡眠实验室在月球周期的相反阶段进行两次访问。我们将使用多导睡眠图唤醒和睡眠 记录，以及研究昼夜节律阶段和月相中潜在的月球每月变化的恒定常规协议 睡眠剥夺后睡眠的稳态调节。 几十年来，月亮是否会影响睡眠一直是一个备受争议的问题。我们最近的工作表明 在现实生活条件下，睡眠模式在月球周期中以一种非常可预测的方式变化，在非常不同的情况下 不同的人群和不同的环境下。该项目旨在阐明这一机制 调节的发生，这将进一步我们了解人类睡眠的调节及其对健康和健康的影响 疾病。