Regulation of Circadian Rhythms and Sleep by The Lunar Month

农历月份对昼夜节律和睡眠的调节

• 批准号: 10514347
• 负责人: Horacio O De La Iglesia
• 金额: $ 56.95万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-25 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10514347
• 关键词: Address; Affect; Argentina; Body Temperature; Circadian Rhythms; Communities; Data; Disease; Elderly; Electricity; Environment; Event; Evolution; Geography; Goals; Gold; Habitats; Health; Human; Hydrocortisone; Impairment; Individual; Industrialization; Laboratories; Lead; Life; Light; Measures; Melatonin; Moon; Moon Cycle; Moon Phases; Participant; Pattern; Perception; Persons; Phase; Plasma; Pollution; Polysomnography; Population; Process; Protocols documentation; Psyche structure; Publishing; Recording of previous events; Recovery; Regulation; Rural; Sleep; Sleep Deprivation; Sleep disturbances; Societies; System; Testing; Time; Urban Community; Urbanization; Variant; Visit; Wakefulness; Work; awake; base; circadian; circadian pacemaker; circadian regulation; indigenous community; light intensity; pressure; rural area; sleep onset; sleep pattern; sleep regulation; sleep regulatory center; university student; urban area; urban setting; young adult

PROJECT SUMMARY Throughout evolution and history humans have progressively isolated themselves from the natural cycles by building artificial habitats that shield them from the external environment. This has vastly affected when and how much humans sleep, especially since the near universalization of electric light. The key to this isolation and change in sleep patterns is the ability to manipulate artificial light and extend activity into the nighttime. A recent study from our laboratory found that the timing of sleep changes across the moon cycle, with later and shorter events of night sleep on the nights leading up to the full moon. Surprisingly, we found this lunar cycle modulation not only in rural but also in urban environments. Sleep is controlled by two simultaneous processes: the circadian clock determines the optimal times for sleep throughout the 24-h cycle while the homeostatic drive for sleep increases as we stay awake. The two processes combine to determine the natural human patterns of night sleep. This project aims to determine which of these two mechanisms that regulate sleep is affected throughout the moon cycle to delay and shorten sleep on the nights before full moon. We will combine longitudinal field recordings of sleep and sleep laboratory strategies to address the following two aims: Specific Aim 1: Assess circadian phase at opposite phases of the moon cycle in Toba/Qom communities. We will conduct longitudinal monitoring of sleep in rural and urban native Toba/Qom communities in northern Argentina. In individuals with robust lunar patterns we will assess the phase of the dim-light melatonin onset (DLMO), the gold- standard for determining circadian phase in humans, in the days leading to the full and new moons. Our hypothesis is that the phase of the circadian clock is modulated across the moon cycle, and predicts that the DLMO phase will be delayed on the days preceding the full moon relative to the pre-new moon days. Specific Aim 2: Assess circadian phase, and circadian and homeostatic regulation of sleep at opposite phases of the moon cycle in a highly urbanized community. We have already confirmed that this lunar modulation is present even in industrialized societies, where artificial light during the evening reigns over the full moon’s light. We will screen Seattle participants through longitudinal sleep monitoring and select those with the most robust lunar rhythms to participate in sleep laboratory visits twice at the opposite phases of the moon cycle. We will use polysomnographic wake and sleep recordings, as well as a constant routine protocol to study the potential lunar monthly change in circadian phase and in the homeostatic regulation of sleep after sleep deprivation. Whether the moon can affect sleep has been a matter of high controversy for decades. Our recent work demonstrated that sleep patterns vary across the moon cycle in a very predictable manner in real life conditions, in very different populations and under different environments. This project aims to shed light on the mechanisms through which this modulation occurs, which will further our understanding of the regulation of human sleep, and its impact on health and disease.

项目摘要 通过进化和历史，人类通过建造逐渐与自然周期隔离 人造栖息地将其避免外部环境。这极大地影响了何时以及多少人 睡眠，特别是由于电灯的几乎普遍化。这种隔离和睡眠方式变化的关键是 操纵人造光并将活动扩展到夜间的能力。我们实验室的最新研究发现 睡眠时间在月球周期中发生变化，晚上夜间睡眠的较短事件较短 到满月。令人惊讶的是，我们发现这种月球周期的调制不仅在粗糙的城市环境中，而且在城市环境中。 睡眠由两个简单的过程控制：昼夜节律确定睡眠的最佳时间 在整个24小时的周期中，随着我们保持清醒的状态，睡眠稳态驱动器会增加。这两个过程结合在一起 确定夜间睡眠的自然人类模式。该项目旨在确定这两个项目 调节睡眠的机制在整个月球周期中受到影响，以延迟和缩短睡眠 满月之前。我们将结合睡眠和睡眠实验室策略的纵向现场记录，以解决 以下两个目标： 特定目标1：在Toba/QOM社区的月球周期相反的阶段评估昼夜节相。我们将 在阿根廷北部的农村和城市土著Toba/QOM社区中对睡眠进行纵向监测。在 具有健壮的月球模式的个体我们将评估昏暗的褪黑激素发作（DLMO）的阶段，金 - 确定人类昼夜节律阶段的标准，在导致全新卫星的日子里。我们的假设是 昼夜节律的阶段在整个月球周期中进行了调制，并预测DLMO相将是 相对于新月前的日子，在满月之前的天数延迟。 特定目的2：评估昼夜节律，昼夜节律和稳态调节睡眠的相反阶段的睡眠调节 月球周期在高度城市化的社区中。我们已经确认，即使在 工业化的社会，晚上的人造光统治着满月的光线。我们将筛选西雅图 通过纵向睡眠监控参与者，并选择具有最强大午餐节奏的人参加 睡眠实验室在月球周期的相对阶段两次访问。我们将使用多摄影症唤醒和睡眠 记录以及恒定的常规协议，以研究昼夜节律的潜在月球每月变化和 睡眠剥夺后睡眠的体内稳态调节。 数十年来，月亮是否会影响睡眠一直存在很大的争议。我们最近的工作证明了 在现实生活条件下，这种睡眠模式在月球周期中以非常可预测的方式有所不同 种群和不同环境。该项目旨在阐明该项目的机制 进行调节，这将进一步了解我们对人类睡眠的调节及其对健康的影响 疾病。