Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness
用于严重精神疾病社交康复的情境感知移动干预
基本信息
- 批准号:10544170
- 负责人:
- 金额:$ 72.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-10 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAddressAnhedoniaAnxietyAreaAttitudeAwarenessBehavior TherapyBeliefCellular PhoneClinicalClinical TrialsCognitiveCognitive TherapyCommunitiesDevicesDigital biomarkerDistalDoseDropoutEcological momentary assessmentEmotionalExposure toFrequenciesGoalsHealth PrioritiesHomeIndividualInterventionInvestigational TherapiesLinkLocationMeasurementMeasuresMediatingMediationMonitorMood DisordersMorbidity - disease rateNational Institute of Mental HealthOutcomeOutpatientsParticipantPatient Self-ReportPerceptionPerformancePersonsPhaseProcessPsychosesPsychotherapyRecoveryRecovery of FunctionResearchResourcesRewardsSamplingSchizophreniaSeveritiesSiteSocial BehaviorSocial EnvironmentSocial FunctioningSocial InteractionSocial PerceptionSocial ProcessesSocial isolationSymptomsSystemTechnologyTherapeutic InterventionTimeTravelWorkanxiousautomated interventionbehavior changeclinically significantcommunity settingdesigndigital assessmentdigital healthdisabilityeconomic impactexperiencefunctional improvementimprovedmicrophonemortalitynew technologynovelphysical conditioningpositive emotional staterandomized trialrecruitresponsesensorsevere mental illnesssmartphone applicationsocialsocial deficitssocial engagementsocial interventionstelecoachingtelephone coachingtherapy development
项目摘要
PROJECT SUMMARY/ABSTRACT
This experimental therapeutics R61/R33 proposal responds to RFA-MH-18-704. The goal of this project
is to evaluate a new technology-supported blended intervention aimed at reducing social isolation and improving
social functioning in serious mental illness (SMI). Social isolation is common in SMI and leads to morbidity and
limits functional recovery. Unfortunately, few available interventions specifically target social isolation and its
determinants in SMI, which include anxious social avoidance, defeatist attitudes toward interactions, and social
anhedonia. Moreover, intervention development in this area is limited by imprecise measurement of social
interactions, processes, and related constructs. Our new blended intervention, mobile Social Interaction Therapy
by Exposure (mSITE), blends brief in-person psychotherapy with context-triggered mobile smartphone
intervention and remote telephone coaching. mSITE builds on preliminary work indicating that blended mobile
interventions are acceptable and both strengthen and shorten cognitive behavioral intervention. Recent work by
our group and others indicates that contexts, such as being at home or alone, exacerbates social defeatist
attitudes and perceptions of social threat. mSITE is unique in that it uses smartphone sensors (e.g., GPS,
conversation sensing) to trigger intervention content tailored to specific social contexts, such as when home
alone for extended periods or after a social interaction in the community, in order for cognitive and behavioral
interventions to be delivered at the “right place, right time.” In addition, the study will be the first to examine
passive sensing measures as outcomes in a clinical trial in SMI, by deriving objective digital markers of negative
symptoms and social engagement using smartphone sensors (GPS and microphone) to monitor distance
traveled, time spent at home, and conversations. In the R61 phase, we will recruit people with SMI who have
limited social engagement. We will then conduct an open trial of mSITE, evaluating whether the intervention
leads to clinically significant changes in the frequency of social interactions (the target mechanism). We will also
determine the dose of app plus remote coaching necessary to achieve this effect, by evaluating change at 12,
18, or 24 weeks. If go/no go criteria are met (medium effect size increase in social interactions and < 20%
dropout) in the R61 phase, the R33 phase will include a randomized trial contrasting mSITE with a therapist and
device time-equivalent supportive contact (SC) condition. We will evaluate whether mSITE leads to greater
improvement in social interactions, negative symptoms and social functioning relative to SC. We also predict
that increases in social interactions will mediate improvements in experiential negative symptoms and social
functioning. Our project responds directly to NIMH Strategic Aim 3.1, by evaluating a new behavioral intervention
that targets functional improvement and by validating new digital biomarkers for objective measurement of social
processes. Our project is also responsive to the NIMH Digital Health Priority Area by advancing digital
assessment and context-aware mobile interventions, which are designed to be scalable to community settings.
项目总结/文摘
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Colin A. Depp其他文献
The intersection of structural social factors, loneliness, and social activity in individuals with psychotic disorders
精神障碍患者中结构性社会因素、孤独感与社交活动的相互关系
- DOI:
10.1016/j.schres.2025.05.028 - 发表时间:
2025-08-01 - 期刊:
- 影响因子:3.500
- 作者:
Lauren E. McBride;Miya M. Gentry;Amy E. Pinkham;Eric Granholm;Philip D. Harvey;Barton W. Palmer;Ellen E. Lee;Colin A. Depp - 通讯作者:
Colin A. Depp
Enhancing Mental Health Treatment Engagement for Vulnerable Older Populations
- DOI:
10.1016/j.jagp.2012.12.041 - 发表时间:
2013-03-01 - 期刊:
- 影响因子:
- 作者:
Amy Kilbourne;Ariel Gildengers;Colin A. Depp;Martha Sajatovic - 通讯作者:
Martha Sajatovic
Social Isolation and Serious Mental Illness: The Role of Context-Aware Mobile Interventions
社会孤立和严重精神疾病:情境感知移动干预的作用
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:1.6
- 作者:
Subigya Nepal;Arvind Pillai;E. Parrish;Jason Holden;Colin A. Depp;Andrew T. Campbell;E. Granholm - 通讯作者:
E. Granholm
Driven by rewards or punishments? Understanding real world social functioning in anxiety and depressive disorders
- DOI:
10.1016/j.xjmad.2024.100097 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:
- 作者:
Angie M. Gross;Madeleine Rassaby;Samantha N. Hoffman;Colin A. Depp;Raeanne C. Moore;Charles T. Taylor - 通讯作者:
Charles T. Taylor
Feasibility and Validity of Smartphone-based Ecological Momentary Assessment for Mood Monitoring in Older Adults
- DOI:
10.1016/j.apmr.2018.07.317 - 发表时间:
2018-10-01 - 期刊:
- 影响因子:
- 作者:
Alex W.K. Wong;Eric J. Lenze;Christopher Metts;Colin A. Depp;Raeanne C. Moore;Thomas L. Rodebaugh;Jiayu Wang;Michael D. Yingling;Michelle L. Voegtle;Julie Loebach Wetherell - 通讯作者:
Julie Loebach Wetherell
Colin A. Depp的其他文献
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{{ truncateString('Colin A. Depp', 18)}}的其他基金
iTEST: Introspective Accuracy as a Novel Target for Functioning in Psychotic Disorders
iTEST:内省准确性作为精神障碍功能的新目标
- 批准号:
10642405 - 财政年份:2023
- 资助金额:
$ 72.77万 - 项目类别:
Transdiagnostic Reward System Dynamics and Social Disconnection in Suicide
跨诊断奖励系统动态和自杀中的社会脱节
- 批准号:
10655760 - 财政年份:2023
- 资助金额:
$ 72.77万 - 项目类别:
Social Cognitive Mechanisms Underlying Disclosure and Help Seeking Behavior in Late-Life Suicide
晚年自杀中披露和寻求帮助行为背后的社会认知机制
- 批准号:
10592120 - 财政年份:2023
- 资助金额:
$ 72.77万 - 项目类别:
Digital detection of social isolation and loneliness markers of risk for Alzheimer's disease
对阿尔茨海默病风险的社会隔离和孤独标记进行数字检测
- 批准号:
10521991 - 财政年份:2022
- 资助金额:
$ 72.77万 - 项目类别:
Context-Aware Mobile Intervention for Social Recovery in Serious Mental Illness
用于严重精神疾病社交康复的情境感知移动干预
- 批准号:
10356328 - 财政年份:2022
- 资助金额:
$ 72.77万 - 项目类别:
Social Cognition and Suicide in Psychotic Disorders
精神障碍中的社会认知和自杀
- 批准号:
10408540 - 财政年份:2019
- 资助金额:
$ 72.77万 - 项目类别:
Rapid Referral to Suicide Specific Intervention in Psychiatric Emergency Care
精神科紧急护理中快速转诊针对自杀的干预措施
- 批准号:
10305695 - 财政年份:2018
- 资助金额:
$ 72.77万 - 项目类别:
Rapid Referral to Suicide Specific Intervention in Psychiatric Emergency Care
精神科紧急护理中快速转诊针对自杀的干预措施
- 批准号:
9607448 - 财政年份:2018
- 资助金额:
$ 72.77万 - 项目类别:
Rapid Referral to Suicide Specific Intervention in Psychiatric Emergency Care
精神科紧急护理中快速转诊针对自杀的干预措施
- 批准号:
10216349 - 财政年份:2018
- 资助金额:
$ 72.77万 - 项目类别:
Development of a mobile heath augmented brief suicide prevention intervention for people with SMI accessing community care
开发移动健康增强了 SMI 患者获得社区护理的简短自杀预防干预措施
- 批准号:
9370600 - 财政年份:2017
- 资助金额:
$ 72.77万 - 项目类别:
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