Optimizing cochlear implants for music perception

优化人工耳蜗的音乐感知

• 批准号: 10544724
• 负责人: Katelyn Berg
• 金额: $ 7.18万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-29 至 2024-12-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10544724
• 关键词: Action Potentials; Address; Adult; Affect; Apical; Auditory; Awareness; Behavioral; Cochlear Implants; Communication; Counseling; Cueing for speech; Cues; Data; Development; Devices; Discrimination; Effectiveness; Electric Stimulation; Electrodes; Faculty; Frequencies; Funding; Future; Goals; Image; Implanted Electrodes; Knowledge; Liquid substance; Manufacturer; Measures; Mediating; Methods; Mirza; Modeling; Music; Neurobiology; Noise; Outcome; Outcomes Research; Participant; Patients; Pattern; Perception; Performance; Pitch Discrimination; Pitch Perception; Psychophysics; Quality of life; Research; Research Personnel; Rest; Sensorineural Hearing Loss; Speech; Speech Acoustics; Statistical Data Interpretation; Stimulus; Techniques; Testing; Training Programs; United States National Institutes of Health; Universities; Width; Work; design; evidence based guidelines; experimental study; implantation; improved; instrument; interest; member; neural; noise perception; novel strategies; open data; signal processing; simulation; skills; sound; speech in noise; speech recognition; standard care; tenure track

PROJECT SUMMARY / ABSTRACT Cochlear implants (CIs) are the standard treatment for adults with moderate sloping to profound sensorineural hearing loss and enable sound awareness and spoken communication to a high majority of recipients. However, CI outcomes that rely on high-fidelity spectral encoding, such as music perception and speech understanding in noise, remain highly variable. One of the biggest contributors to this variability is channel interaction, but the relationship between spectral-dependent tasks (i.e., pitch, melody, timbre, and speech in noise perception) and channel interaction is not clearly defined. This study aims to manipulate channel interaction via spectral blurring in adult CI recipients to directly measure the effects of channel interaction on spectral-dependent tasks. We will also explore the use of image-based electrode selection as an approach for reducing channel interaction and its impact on music perception. Given that our preliminary data suggest a relationship between electrode placement and psychophysical pitch discrimination, we hypothesize that there will be a negative relationship between channel interaction and music perception outcomes. This hypothesis will be tested using a newly developed method of manipulating the excitation patterns of stimulation directly in CI recipients to investigate the causal relationship between channel interaction and outcomes. This model is advantageous over previous methods because it accounts for the effects of electrical stimulation, neural excitation, and sensorineural hearing loss present in actual CI-mediated listening. Primary Aim 1 will characterize the effects of channel interaction and the impact of spread of excitation (SOE) and electrode placement on pitch discrimination in all participants. Exploratory Aim 2 will measure the degree of image-based electrode selection benefit for CI-mediated pitch discrimination in a subset of participants. Collectively, these data will quantify channel interaction effects directly in CI recipients and provide a model to enable more detailed studies targeting potential uses of image-based electrode selection to improve CI-mediated listening. More broadly, this research should help improve signal processing methods for how stimuli, such as music and speech in noise, are encoded in CI stimulation, and lead to increased utilization of CIs by addressing CI recipient-driven concerns for variable outcomes. The training program will result in the development of knowledge and skills in: 1) auditory neurobiology and the consequences of sensorineural hearing loss, 2) CI signal processing and its limitations, 3) administering behavioral tasks of music perception to CI recipients, and 4) programming and administering direct stimulation experiments. It will also improve essential skills in grantspersonship, professional development, statistical analyses, and open science practices. Each of these skills is critical to achieving the applicant's goal of becoming a tenure-track faculty member at a research- intensive university with an independent line of NIH-funded CI outcomes research.

项目摘要/摘要 人工耳蜗植入物(Cis)是成人中度斜度至深感觉神经病的标准治疗方法。 听力损失，使绝大多数接受者能够感知声音和进行口头交流。 然而，依赖于高保真频谱编码的CI结果，如音乐感知和语音 在噪音中的理解，仍然是高度可变的。造成这种变化的最大因素之一是渠道 交互作用，但依赖于光谱的任务(即，音高、旋律、音色和语音)之间的关系 噪声感知)和通道交互没有明确定义。本研究旨在操控渠道 在成年CI患者中通过光谱模糊进行相互作用，以直接测量通道相互作用对 光谱相关任务。我们还将探索使用基于图像的电极选择作为一种方法 减少渠道互动及其对音乐感知的影响。鉴于我们的初步数据表明 电极放置和心理物理音调辨别之间的关系，我们假设 渠道互动与音乐感知结果之间会存在负相关关系。这一假设 将使用一种新开发的方法进行测试，该方法直接操作刺激的激发模式 CI接受者调查渠道互动和结果之间的因果关系。这个型号是 与以前的方法相比具有优势，因为它考虑了电刺激、神经刺激的影响 在实际的CI介导的听力中，存在兴奋和感觉神经性听力损失。主要目标1将 描述通道相互作用的影响以及激励扩散(SOE)和电极的影响 所有参赛者的音高歧视排名。探索性目标2将测量基于图像的程度 在一部分参与者中，电极选择有利于CI介导的音调辨别。总而言之，这些 数据将直接量化CI接受者中的渠道交互影响，并提供一个模型以实现更多 详细的研究针对基于图像的电极选择的潜在用途，以改善CI中介的听力。 更广泛地说，这项研究应该有助于改进如何刺激的信号处理方法，如音乐和 噪声中语音，在CI刺激中编码，并通过寻址CI来提高CI的利用率 接受者驱动的对可变结果的担忧。该培训计划将导致发展 具备以下方面的知识和技能：1)听觉神经生物学和感音神经性耳聋的后果；2)CI 信号加工及其局限性；3)对CI接受者进行音乐知觉行为任务的管理； 4)设计和实施直接刺激实验。它还将提高以下基本技能： 授予人格、专业发展、统计分析和开放的科学实践。这其中的每一个 要实现申请者成为研究机构终身教职员工的目标，技能至关重要。 拥有由NIH资助的CI结果研究的独立路线的密集大学。