Optimizing cochlear implants for music perception

优化人工耳蜗的音乐感知

• 批准号: 10463082
• 负责人: Katelyn Berg
• 金额: $ 6.76万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-29 至 2024-12-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463082
• 关键词: Action Potentials; Address; Adult; Affect; Apical; Auditory; Awareness; Behavioral; Cochlear Implants; Communication; Counseling; Cueing for speech; Cues; Data; Development; Devices; Discrimination; Effectiveness; Electric Stimulation; Electrodes; Faculty; Foundations; Frequencies; Funding; Future; Goals; Image; Implanted Electrodes; Knowledge; Lead; Liquid substance; Manufacturer Name; Measures; Mediating; Methods; Mirza; Modeling; Music; Neurobiology; Noise; Outcome; Outcomes Research; Participant; Patients; Pattern; Perception; Performance; Pitch Discrimination; Pitch Perception; Psychophysics; Quality of life; Research; Research Personnel; Rest; Sensorineural Hearing Loss; Speech; Speech Acoustics; Statistical Data Interpretation; Stimulus; Techniques; Testing; Training Programs; United States National Institutes of Health; Universities; Width; Work; base; design; evidence based guidelines; experimental study; implantation; improved; instrument; interest; member; noise perception; novel strategies; open data; relating to nervous system; signal processing; simulation; skills; sound; speech in noise; speech recognition; standard care; tenure track

PROJECT SUMMARY / ABSTRACT Cochlear implants (CIs) are the standard treatment for adults with moderate sloping to profound sensorineural hearing loss and enable sound awareness and spoken communication to a high majority of recipients. However, CI outcomes that rely on high-fidelity spectral encoding, such as music perception and speech understanding in noise, remain highly variable. One of the biggest contributors to this variability is channel interaction, but the relationship between spectral-dependent tasks (i.e., pitch, melody, timbre, and speech in noise perception) and channel interaction is not clearly defined. This study aims to manipulate channel interaction via spectral blurring in adult CI recipients to directly measure the effects of channel interaction on spectral-dependent tasks. We will also explore the use of image-based electrode selection as an approach for reducing channel interaction and its impact on music perception. Given that our preliminary data suggest a relationship between electrode placement and psychophysical pitch discrimination, we hypothesize that there will be a negative relationship between channel interaction and music perception outcomes. This hypothesis will be tested using a newly developed method of manipulating the excitation patterns of stimulation directly in CI recipients to investigate the causal relationship between channel interaction and outcomes. This model is advantageous over previous methods because it accounts for the effects of electrical stimulation, neural excitation, and sensorineural hearing loss present in actual CI-mediated listening. Primary Aim 1 will characterize the effects of channel interaction and the impact of spread of excitation (SOE) and electrode placement on pitch discrimination in all participants. Exploratory Aim 2 will measure the degree of image-based electrode selection benefit for CI-mediated pitch discrimination in a subset of participants. Collectively, these data will quantify channel interaction effects directly in CI recipients and provide a model to enable more detailed studies targeting potential uses of image-based electrode selection to improve CI-mediated listening. More broadly, this research should help improve signal processing methods for how stimuli, such as music and speech in noise, are encoded in CI stimulation, and lead to increased utilization of CIs by addressing CI recipient-driven concerns for variable outcomes. The training program will result in the development of knowledge and skills in: 1) auditory neurobiology and the consequences of sensorineural hearing loss, 2) CI signal processing and its limitations, 3) administering behavioral tasks of music perception to CI recipients, and 4) programming and administering direct stimulation experiments. It will also improve essential skills in grantspersonship, professional development, statistical analyses, and open science practices. Each of these skills is critical to achieving the applicant's goal of becoming a tenure-track faculty member at a research- intensive university with an independent line of NIH-funded CI outcomes research.

项目总结/摘要 髋关节植入物（CI）是成人中度倾斜至深度感觉神经性疼痛的标准治疗方法。 听力损失，并使声音意识和口头沟通，以大多数收件人。 然而，依赖于高保真频谱编码的CI结果，如音乐感知和语音， 噪声中的理解，仍然高度可变。造成这种变化的最大因素之一是渠道 相互作用，但是光谱相关任务之间的关系（即，音高、旋律、音色和语音， 噪声感知）和信道交互没有被清楚地定义。这项研究旨在操纵通道 在成人CI接受者中通过频谱模糊的相互作用来直接测量通道相互作用对 光谱相关的任务。我们还将探索使用基于图像的电极选择作为一种方法， 减少声道交互及其对音乐感知的影响。鉴于我们的初步数据显示 电极放置和心理物理音高辨别之间的关系，我们假设， 通道交互和音乐感知结果之间存在负相关关系。这一假设 将使用一种新开发的方法进行测试，该方法直接操纵刺激的兴奋模式， CI接受者调查渠道互动和结果之间的因果关系。该模型 由于其考虑了电刺激、神经刺激和神经刺激的影响， 兴奋和感觉神经性听力损失存在于实际CI介导的听力。目标1将 表征通道相互作用的影响以及激励传播（SOE）和电极的影响 在所有参与者中进行音高辨别。探索性目标2将衡量基于图像的 电极选择有利于参与者子集中CI介导的音高辨别。总的来说，这些 数据将直接量化CI接受者的渠道交互效应，并提供一个模型， 针对基于图像的电极选择的潜在用途以改善CI介导的听力的详细研究。 更广泛地说，这项研究应该有助于改善信号处理方法，以了解刺激，如音乐和 噪声中的语音被编码在CI刺激中，并通过寻址CI而导致CI的利用率增加 对可变结果的顺从性驱动的关注。培训计划将导致发展 知识和技能：1）听觉神经生物学和感音神经性听力损失的后果，2）CI 信号处理及其局限性，3）向CI接受者管理音乐感知的行为任务，以及 4)编程和管理直接刺激实验。它还将提高基本技能， 奖学金、专业发展、统计分析和开放科学实践。这一切成功都 技能是至关重要的，以实现申请人的目标，成为终身教职的研究， 一所拥有独立的NIH资助的CI成果研究的密集型大学。