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Cannabis Vapor Exposure Impacts Reproduction

大麻蒸气暴露影响繁殖

基本信息

批准号：
10568537
负责人：
KANAKO HAYASHI
金额：
$ 22.33万
依托单位：
WASHINGTON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-15 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10568537
关键词：
Abnormal placentation Adult Adverse effects Affect Age American Apoptosis Cannabidiol Cannabis Cells Chronic Cohort Effect Consumption Control Groups DNA DNA Damage DNA Methylation DNA Modification Methylases Data Defect Discipline of Nursing Drug usage Epigenetic Process Estrous Cycle Ethics Exhibits Exposure to Female Fertility First Pregnancy Trimester Generations Germ Cells Health Human Inherited Knowledge Menstruation Mus Neonatal Outcome Ovary Partner in relationship Paternal Exposure Pharmaceutical Preparations Phenotype Plants Plasma Population Pregnancy Pregnant Women Premature Birth Psychoses Psychotropic Drugs Reporting Reproduction Risk Socioeconomic Factors Sperm Count Procedure Sperm Motility Standardization Surveys Testing Testis Tetrahydrocannabinol Toxicology United States Vagina base bisphenol A design histone methyltransferase histone modification in utero insight male marijuana legalization marijuana use marijuana user methylome offspring postnatal pregnant reproductive reproductive function steroid hormone stillbirth transcriptome transmission process vapor

项目摘要

Project Summary Cannabis is considered the most widely used psychoactive drug in the United States and all over the world. In 2020, the National Survey on Drug Use and Health (NSDUH) has reported that over 48 million Americans (~16% of the population) ages 12 and older used cannabis in the past year. This number has increased due to the expanding legalization of cannabis consumption in the US. Higher potency strains of cannabis plants have emerged over the past two decades. Unsurprisingly, adverse health outcomes associated with cannabis consumption have also been increasing. The proposed study will provide the first impact, which is the transgenerational effects of in utero and nursing cannabis vapor exposure on phenotypic defects of male and female reproductive functions. Because cannabis is a psychoactive drug, chronic or frequent use of cannabis is associated with a variety of adverse health outcomes. However, little is known about its effects on reproduction, especially the long-term consequences of cannabis on offspring and subsequent generations. To date, no systematic studies examining reproductive phenotypic defects and their associated mechanisms caused by cannabis have been performed. In addition, it is entirely unknown whether the adverse effects of cannabis on reproduction are sustained via germline transmission to subsequent generations. Therefore, this application proposes as a first step to examine the transgenerational effects of cannabis vapor exposure on male and female reproductive functions. We will characterize how cannabis vapor exposure during pregnancy and nursing affects male and female reproductive parameters in neonatal and adult testes and ovaries to understand paternally or maternally transmitted alterations in male or female germ cells. Because at least 7% of pregnant women use cannabis throughout pregnancy (~12% during the first trimester and 5.3% daily users), an appreciation of the impact of cannabis use on reproductive functions in subsequent offspring is crucial.

项目总结