Cannabis Vapor Exposure Impacts Reproduction
大麻蒸气暴露影响繁殖
基本信息
- 批准号:10568537
- 负责人:
- 金额:$ 22.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:Abnormal placentationAdultAdverse effectsAffectAgeAmericanApoptosisCannabidiolCannabisCellsChronicCohort EffectConsumptionControl GroupsDNADNA DamageDNA MethylationDNA Modification MethylasesDataDefectDiscipline of NursingDrug usageEpigenetic ProcessEstrous CycleEthicsExhibitsExposure toFemaleFertilityFirst Pregnancy TrimesterGenerationsGerm CellsHealthHumanInheritedKnowledgeMenstruationMusNeonatalOutcomeOvaryPartner in relationshipPaternal ExposurePharmaceutical PreparationsPhenotypePlantsPlasmaPopulationPregnancyPregnant WomenPremature BirthPsychosesPsychotropic DrugsReportingReproductionRiskSocioeconomic FactorsSperm Count ProcedureSperm MotilityStandardizationSurveysTestingTestisTetrahydrocannabinolToxicologyUnited StatesVaginabasebisphenol Adesignhistone methyltransferasehistone modificationin uteroinsightmalemarijuana legalizationmarijuana usemarijuana usermethylomeoffspringpostnatalpregnantreproductivereproductive functionsteroid hormonestillbirthtranscriptometransmission processvapor
项目摘要
Project Summary
Cannabis is considered the most widely used psychoactive drug in the United States and all over the world. In
2020, the National Survey on Drug Use and Health (NSDUH) has reported that over 48 million Americans
(~16% of the population) ages 12 and older used cannabis in the past year. This number has increased due to
the expanding legalization of cannabis consumption in the US. Higher potency strains of cannabis plants have
emerged over the past two decades. Unsurprisingly, adverse health outcomes associated with cannabis
consumption have also been increasing. The proposed study will provide the first impact, which is the
transgenerational effects of in utero and nursing cannabis vapor exposure on phenotypic defects of male and
female reproductive functions. Because cannabis is a psychoactive drug, chronic or frequent use of cannabis
is associated with a variety of adverse health outcomes. However, little is known about its effects on
reproduction, especially the long-term consequences of cannabis on offspring and subsequent generations. To
date, no systematic studies examining reproductive phenotypic defects and their associated mechanisms
caused by cannabis have been performed. In addition, it is entirely unknown whether the adverse effects of
cannabis on reproduction are sustained via germline transmission to subsequent generations. Therefore, this
application proposes as a first step to examine the transgenerational effects of cannabis vapor exposure on
male and female reproductive functions. We will characterize how cannabis vapor exposure during pregnancy
and nursing affects male and female reproductive parameters in neonatal and adult testes and ovaries to
understand paternally or maternally transmitted alterations in male or female germ cells. Because at least 7%
of pregnant women use cannabis throughout pregnancy (~12% during the first trimester and 5.3% daily users),
an appreciation of the impact of cannabis use on reproductive functions in subsequent offspring is crucial.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KANAKO HAYASHI其他文献
KANAKO HAYASHI的其他文献
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{{ truncateString('KANAKO HAYASHI', 18)}}的其他基金
18th Northwest Reproductive Sciences Symposium (NWRSS)
第十八届西北生殖科学研讨会(NWRSS)
- 批准号:
10385401 - 财政年份:2021
- 资助金额:
$ 22.33万 - 项目类别:
Complex inflammatory mechanisms and therapeutic targeting in endometriosis
子宫内膜异位症的复杂炎症机制和治疗靶向
- 批准号:
10376245 - 财政年份:2021
- 资助金额:
$ 22.33万 - 项目类别:
Complex inflammatory mechanisms and therapeutic targeting in endometriosis
子宫内膜异位症的复杂炎症机制和治疗靶向
- 批准号:
10178341 - 财政年份:2021
- 资助金额:
$ 22.33万 - 项目类别:
Complex inflammatory mechanisms and therapeutic targeting in endometriosis
子宫内膜异位症的复杂炎症机制和治疗靶向
- 批准号:
10612802 - 财政年份:2021
- 资助金额:
$ 22.33万 - 项目类别:
Transgenerational epigenetic alterations on male germ cells caused by bisphenol S
双酚S引起的雄性生殖细胞的跨代表观遗传改变
- 批准号:
10183252 - 财政年份:2020
- 资助金额:
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Development of new therapeutic strategies for endometriosis
子宫内膜异位症新治疗策略的开发
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9373498 - 财政年份:2017
- 资助金额:
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Mechanisms of WNT7A-FGF1 signaling and their therapeutic potential in ovarian can
WNT7A-FGF1 信号传导机制及其在卵巢癌中的治疗潜力
- 批准号:
8572502 - 财政年份:2013
- 资助金额:
$ 22.33万 - 项目类别:
Functional Role of Wnt11 in Uterine Development and Adult Function
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8063382 - 财政年份:2010
- 资助金额:
$ 22.33万 - 项目类别:
Functional Role of Wnt11 in Uterine Development and Adult Function
Wnt11 在子宫发育和成人功能中的功能作用
- 批准号:
7585105 - 财政年份:2009
- 资助金额:
$ 22.33万 - 项目类别:
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