Community-Level Effects of Structural Racism on Women's Circadian Rhythm Pattern and Heatlh

项目总结 本补充资料的目的是研究社区层面的结构性影响之间的联系 年照顾幼儿的妇女中的种族主义、昼夜节律模式和健康指标 服务不足的社区。昼夜节律紊乱与不良的健康结局有关，包括 心血管疾病、糖尿病、肥胖症、癌症和抑郁症，以及产妇患病和贫穷 分娩结果包括妊娠期糖尿病、先兆子痫、低出生体重和早产。活着的女性 在服务不足的社区，由于社区层面的影响，昼夜节律扰乱的风险很高 结构性种族主义，如噪音污染、光污染和社区暴力。女性照顾者 由于性别差异的照顾，幼儿被打乱昼夜节律的风险也增加了 责任，包括夜间照看任务。然而，昼夜节律的结构和社会决定因素 没有对生活在服务不足社区的妇女的节律模式进行审查。在这 作为补充，我们利用了主要调查者的母公司R00研究的数据，这是一项横断面研究 母子二元组，寻求检查潜在的生物，行为和遗传机制 有毒应激的代际传递。在拟议的补编中，我们将使用妇女的措施 昼夜节律模式(通过活动记录实现的休息-活动节律)和健康(压力生物标记物、人体测量学、 身体/精神健康)，在父母R00中收集作为关键结果变量。与 康涅狄格大学地理系和康涅狄格州儿童医学中心的专家 中心(CCMC)地理信息系统(GIS)实验室，我们将使用GIS和空间分析来 为结构性种族主义的社区影响构建创新的、客观的衡量标准。基于国家 少数民族健康和健康差距研究所(NIMHD)研究框架，社区一级变量 将包括物理/建筑环境(光污染、噪音污染)和社会文化指标 环境(枪支暴力、社会脆弱性)。通过利用与父母R00中的女性收集的数据 并使用二次分析开发新的、客观的社区级变量，本附录提供了 以创新、高效的方法解决与妇女健康有关的新研究问题，同时还 产生有价值的数据，为父母的研究提供信息。拟议的补编与联合国经济及社会理事会的优先事项 国立卫生研究院，包括《跨国立卫生研究院妇女健康战略计划》中概述的目标 研究和2021年NIH睡眠研究计划。我们期待这项研究的结果将提供批判性的、新颖的 对可能导致女性照顾者健康和健康不平等的结构性因素的见解 许多儿童生活在服务不足的社区。

PROJECT SUMMARY The purpose of this supplement is to examine associations between community-level effects of structural racism, circadian rhythm patterns, and indicators of health among women caring for young children living in underserved communities. Circadian rhythm disruption is associated with poor health outcomes including cardiovascular disease, diabetes, obesity, cancer, and depression, as well as maternal morbidities and poor birth outcomes including gestational diabetes, preeclampsia, low birth weight, and preterm birth. Women living in underserved communities are at high-risk for circadian rhythm disruption due to the community-level effects of structural racism, such as noise pollution, light pollution, and community violence. Women caregivers of young children are also at increased risk for disrupted circadian rhythm due to gendered caregiving responsibilities, including nighttime caregiving tasks. However, structural and social determinants of circadian rhythm patterns among women living in underserved communities have not been examined. In this supplement, we leverage data from the Principal Investigator’s Parent R00 study, a cross-sectional study of maternal-child dyads that seeks to examine biological, behavioral, and genetic mechanisms underlying the intergenerational transmission of toxic stress. In the proposed supplement, we will use measures of women’s circadian rhythm patterns (rest-activity rhythms via actigraphy) and health (stress biomarkers, anthropometrics, physical/mental health) that are collected in the Parent R00 as key outcome variables. In collaboration with experts from the University of Connecticut Department of Geography and the Connecticut Children’s Medical Center (CCMC) Geographic Information Systems (GIS) laboratory, we will use GIS and spatial analysis to construct innovative, objective measures of community-level effects of structural racism. Based on the National Institute on Minority Health and Health Disparities (NIMHD) Research Framework, community-level variables will include indicators of the physical/built environment (light pollution, noise pollution) and the sociocultural environment (gun violence, social vulnerability). By leveraging data collected with women in the Parent R00 and developing new, objective community-level variables using secondary analyses, this supplement offers an innovative, efficient approach to addressing new research questions pertinent to women’s health while also generating valuable data to inform the parent study. The proposed supplement is aligned with priorities of the National Institutes of Health, including goals outlined in the Trans-NIH Strategic Plan for Women’s Health Research and the 2021 NIH Sleep Research Plan. We expect results of this study will provide critical, novel insights into the structural factors that may contribute to health and health inequities among women caregivers of young children living in underserved communities.