Project 2: Oxidative Stress and Harmful Constituent Levels Associated with Little Cigars
项目 2:与小雪茄相关的氧化应激和有害成分水平
基本信息
- 批准号:10665897
- 负责人:
- 金额:$ 25.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-30 至 2028-08-31
- 项目状态:未结题
- 来源:
- 关键词:4-(methylnitrosamino)-1-(3-pyridyl)-1-butanoneAcetaldehydeAcetatesAcroleinAddressAffectAromatic Polycyclic HydrocarbonsAuthorization documentationBiologicalBiological MarkersC-reactive proteinCarcinogensCelluloseCenters for Disease Control and Prevention (U.S.)CharacteristicsChemicalsCigarCigaretteCigarette SmokerCross-Over StudiesDataDevelopmentElectronic cigaretteExhalationFree RadicalsGasesGoalsHealthHispanicHumanHydrogen PeroxideInflammationIntercellular adhesion molecule 1Interleukin-6IsoprostanesKnowledgeLaboratoriesLengthLinear ModelsMainstreamingMeasuresMethodsMissionModelingNicotineNitratesNitrosaminesOutputOxidantsOxidative StressParticulatePersonsPhasePhysical condensationPopulationPriceProductionProtocols documentationRandomizedRegulationResearch DesignRodSamplingShapesSmokeSmokerSmokingTestingTobaccoTobacco DependenceTobacco smokeToxic effectVariantWeightaddictionauthoritybehavior measurementcombustible cigarettedensitydesigne-cigarette aerosolsenvironmental tobacco smoke exposureexposed human populationinflammatory markerlow socioeconomic statusmensecondary outcometobacco exposuretobacco productstoxicantventilation
项目摘要
Project Summary/Abstract: Project 2
The overall goal of this project is to determine the toxicity and harm associated with little cigars, with an
emphasis on measuring the oxidants in mainstream smoke delivery and their biological effects. The project is
responsive to the RFA Scientific Domains of “Toxicity” and “Addiction.” The project helps form the
integrative theme of the overall TCORS that focuses on harm generated from tobacco-related oxidants and
the development of reliable methods for product testing.
Little cigars have become an increasingly popular tobacco product because they offer price
advantages compared to traditional cigarettes. However, emerging evidence by our group and the Tobacco
Products Laboratory of the Centers for Disease Control implicate little cigars as more toxic than even
cigarettes. However, there is still much to be determined about the relative harm from little cigars including
their effects on oxidative stress, damage and inflammation. Our specific aims are:
Aim1. Determine the levels of gas phase and particulate phase free radicals and other Harmful and
Potentially Harmful Constituents (carbonyls, PAHs, NNK,NNN) in the smoke of the 40 most common little cigar
brands under machine-smoked protocols (FTC, CI). The effects of physical and chemical product features
such as filter ventilation level, rod length and tobacco nitrate levels, which can be regulated under FDA
authority, will be modelled against levels of these constituents.
Aim2. Determine the effects of little cigar features on human exposure to tobacco smoke oxidants. In a
balanced randomized cross-over study design in diverse smokers, subjects will be assigned to 6 exposure
groups. These include a high oxidant unflavored little cigar exposure condition, a low oxidant unflavored little
cigar exposure condition, a high oxidant flavored exposure condition, a low oxidant flavored exposure little
cigar exposure condition, their usual cigarette, and a control condition (unlit little cigar). Following the smoking
of each product, exhaled breath condensate samples will be collected at baseline (-15), 30, 60, 90, 120 and
150 minutes. Samples will be analyzed for levels of oxidant/inflammatory markers including hydrogen peroxide,
8-isoprostanes, and C-reactive protein, as well as nicotine, NNK and NNN.
Aim 3. Determine the levels of biomarkers of potential harm in current users of little cigars relative to
other tobacco products, including cigarettes and e-cigarettes in the Population and Tobacco Health Study
(PATH). Aim 3a. Using Wave 1 and Wave 5 data, we will analyze and compare biomarkers of potential harm
including oxidative stress (8-isoprostane) and inflammation (Soluble intercellular adhesion molecule-1,
Interleukin 6). Secondary outcomes will include biomarkers of other tobacco smoke toxicants and nicotine
metabolites, and behavioral measures of tobacco addiction. Aim 3b. Determine the effect of nitrate levels and
rod length on biomarkers of potential harm.
项目概要/摘要:项目2
该项目的总体目标是确定与小雪茄相关的毒性和危害,
重点是测量主流烟气输送中的氧化剂及其生物效应。该项目
响应RFA科学领域的“毒性”和“成瘾”。该项目有助于形成
整体TCORS的综合主题,重点关注烟草相关氧化剂产生的危害,
开发可靠的产品测试方法。
小雪茄已经成为一种越来越受欢迎的烟草产品,因为它们提供价格
与传统香烟相比,然而,我们小组和烟草公司的新证据表明,
美国疾病控制中心的产品实验室暗示,小雪茄的毒性甚至比
香烟然而,关于小雪茄的相对危害还有很多有待确定的地方,包括
它们对氧化应激、损伤和炎症的影响。我们的具体目标是:
目标1.测定气相和颗粒相自由基和其他有害和
40种最常见的小雪茄烟雾中的潜在有害成分(羰基化合物,多环芳烃,NNK,NNN)
根据机器吸烟协议(联邦贸易委员会,CI)的品牌。产品物理和化学特性的影响
例如过滤器通风水平、杆长度和烟草硝酸盐水平,这些可以在FDA下进行调节
将根据这些选民的级别进行建模。
目标2。确定小雪茄特征对人体暴露于烟草烟雾氧化剂的影响。中
在不同吸烟者中进行的平衡随机交叉研究设计,受试者将被分配至6个暴露组
组这些包括高氧化剂无味少雪茄暴露条件,低氧化剂无味少
雪茄暴露条件,高氧化剂味暴露条件,低氧化剂味暴露条件,
雪茄暴露条件,他们通常的香烟,和控制条件(未点燃的小雪茄)。吸烟后
在每种产品中,将在基线(-15)、30、60、90、120和
150分钟将分析样品的氧化剂/炎症标志物水平,包括过氧化氢,
8-异前列腺素和C-反应蛋白,以及尼古丁、NNK和NNN。
目标3。确定当前小雪茄使用者中潜在危害的生物标志物水平,
人口与烟草健康研究中的其他烟草产品,包括香烟和电子烟
(PATH)。目标3a。使用Wave 1和Wave 5数据,我们将分析和比较潜在危害的生物标志物
包括氧化应激(8-异前列腺素)和炎症(可溶性细胞间粘附分子-1,
白细胞介素6)。次要结果将包括其他烟草烟雾毒物和尼古丁的生物标志物
代谢物和烟草成瘾的行为测量。目标3b。确定硝酸盐水平的影响,
潜在伤害生物标志物上的棒长度。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('JOSHUA E MUSCAT', 18)}}的其他基金
Time to first cigarette and early detection in the National Lung Screening Trial
国家肺部筛查试验中首次吸烟的时间和早期发现
- 批准号:
9022934 - 财政年份:2015
- 资助金额:
$ 25.17万 - 项目类别:
Project 1: Switching to Progressively Reduced Nicotine Content Cigarett p212-247
项目 1:改用逐渐降低尼古丁含量的香烟 p212-247
- 批准号:
8594386 - 财政年份:2013
- 资助金额:
$ 25.17万 - 项目类别:
Developmental/Pilot Research (Component II) p386-397
发展/试点研究(第二部分)p386-397
- 批准号:
8594396 - 财政年份:2013
- 资助金额:
$ 25.17万 - 项目类别:
Socioeconomic status and smoking exposure in Appalachia
阿巴拉契亚地区的社会经济状况和吸烟暴露
- 批准号:
8181854 - 财政年份:2011
- 资助金额:
$ 25.17万 - 项目类别:
Socioeconomic status and smoking exposure in Appalachia
阿巴拉契亚地区的社会经济状况和吸烟暴露
- 批准号:
8662214 - 财政年份:2011
- 资助金额:
$ 25.17万 - 项目类别:
Socioeconomic status and smoking exposure in Appalachia
阿巴拉契亚地区的社会经济状况和吸烟暴露
- 批准号:
8722076 - 财政年份:2011
- 资助金额:
$ 25.17万 - 项目类别:
Socioeconomic status and smoking exposure in Appalachia
阿巴拉契亚地区的社会经济状况和吸烟暴露
- 批准号:
8478072 - 财政年份:2011
- 资助金额:
$ 25.17万 - 项目类别:
Socioeconomic status and smoking exposure in Appalachia
阿巴拉契亚地区的社会经济状况和吸烟暴露
- 批准号:
8328974 - 财政年份:2011
- 资助金额:
$ 25.17万 - 项目类别:
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