Biostatistics and Data Management Core

项目摘要/摘要：生物统计和数据管理核心 生物统计和数据管理核心将为三个主要项目、试点项目和 实习生。核心拥有一支由经验丰富的生物统计学家和其他具有广泛多样性的量化专家组成的团队 技能，包括创新的统计分析、RedCap数据库设计和管理、临床试验 监测和报告以及生物信息学。Core在之前的一年中开发了一个大型基础设施 (宾夕法尼亚州立大学TCORS；P50 DA036107)，并与每个项目负责人密切合作。 核心将成为整个项目不可或缺的一部分。它的成员将参加定期的项目会议 并将通过欢迎现场讨论和数据快速周转来提供及时和高质量的服务 分析(1-3个工作日)。核心主任还将向每个外部咨询机构提交进度报告 董事会会议。核心将采取措施加强研究的严谨性和再现性，使用 Redcapp数据库管理系统，以确保数据的准确性，提供研究进展的每周报告， 并确保在数据收集和分析开始之前有一套明确定义的科学问题， 使用最佳做法和透明的统计方法。总体而言，三个主要项目，试点和 职业发展活动检验关于烟草产品的假设及其对成瘾和毒性的影响 以及对健康的影响。生物统计学核心员工已经非常精通烟草研究，并与人合著了 TCORS出版物，并就与烟草具体问题有关的统计方法提供咨询意见。 他们将参加职业提升培训计划，包括指导学生和服务 作为TCORS认可课程的班主任。此外，他们还将担任试点项目的统计顾问 项目，包括在电力计算、设计问题和结果统计分析方面提供协助。

PROJECT SUMMARY / ABSTRACT: Biostatistics and Data Management Core The Biostatistics and Data Management Core will provide support for the three Main Projects, Pilot Projects and trainees. The Core has a team of experienced biostatisticians and other quantitative experts with a wide diversity of skills, including innovative statistical analysis, REDCAP database design and management, clinical trials monitoring and reporting and bioinformatics. The Core has developed a large infrastructure in the previous funding period (Penn State TCORS; P50 DA036107) and has worked closely with each of the project leaders. The Core will be an integral part of the whole Project. Its members will participate in regular project meetings and will provide timely and high-quality service by welcoming walk-in discussion and by quick turnaround in data analysis (1-3 workdays). The Core Director will also present progress reports at each of the External Advisory Board meetings. The core will take steps to enhance the rigor and reproducibility of the research, using the REDCAP database management system to ensure data accuracy, providing weekly reports of study progress, and ensuring that have a set of clearly defined scientific questions before data collection and analysis begins, using best-practice and transparent statistical methods. Overall, the three Main Projects, Pilot Projects and Career Development activities test hypotheses about tobacco products and their impact on addiction, toxicity and health effects. The biostatistics Core staff have become well versed in tobacco research, have co-authored TCORS publications, and provide advice on statistical approaches as they relate to tobacco-specific issues. They will participate in the Career Enhancement Training Program, including mentoring of students and serving as class instructors in the TCORS-accredited courses. Additionally, they will be statistical consultants to the pilot projects, including providing assistance with power calculations, design issues and statistical analyses of results.