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Functional organization of the superior temporal gyrus for speech perception

颞上回言语感知的功能组织

基本信息

批准号：
10665793
负责人：
Edward Chang
金额：
$ 68.19万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10665793
关键词：
Acoustics Address Aphasia Auditory Auditory area Behavioral Brain Characteristics Clinical Code Complex Comprehension Cues Development Dimensions Dissociation Dyslexia Electrodes Elements Event Goals Human Implant Individual Investigation Knowledge Language Language Disorders Lateral Linguistics Link Methodology Methods Modeling Music Neurons Neurosciences Neurosurgical Procedures Noise Patients Perception Phonetics Play Population Property Psychophysics Rehabilitation therapy Research Resolution Role Signal Transduction Site Speech Speech Acoustics Speech Perception Speech Sound Stimulus Stress Superior temporal gyrus Surface Temporal Lobe Time Work autism spectrum disorder awake computational neuroscience density experience innovation insight language perception multi-scale modeling neural neuroimaging neurophysiology novel diagnostics phonology remediation response sensory input signal processing sound spatiotemporal speech processing statistics temporal measurement theories

项目摘要

PROJECT SUMMARY The basic mechanisms underlying comprehension of spoken language are still largely unknown. Over the past decade, we have gained new insights to how the human brain extracts the most fundamental linguistic elements (consonants and vowels) from a complex and highly variable acoustic signal. However, the next set of questions await pertaining to the sequencing of those auditory elements and how they are integrated with other features, such as, the amplitude envelope of speech. Further investigation of the cortical representation of speech sounds can likely shed light on these fundamental questions. Previous research has implicated the superior temporal cortex in the processing of speech sounds, but little is known about how these sounds are linked together into the perceptual experience of words and continuous speech. The recording of neural activity directly from the cortical surface is a promising approach to study this since it can provide both high spatial and temporal resolution. This proposal seeks to examine the mechanisms of phonetic encoding by utilizing neurophysiological recordings obtained during neurosurgical procedures. High-density electrode arrays and advanced signal processing will be utilized to unravel both local and population encoding of speech sounds in the lateral temporal cortex. The overall goal is to determine how the brain extracts linguistic elements from a complex acoustic speech signal towards better understanding and remediating human language disorders.

项目摘要口语理解的基本机制在很大程度上仍然是未知的。过去十年来，我们对人类大脑如何提取最基本的语言有了新的认识。从一个复杂的和高度可变的声学信号的元素（辅音和元音）。然而，下一集关于这些听觉元素的顺序以及它们如何与其他特征，例如语音的幅度包络。皮层代表的进一步研究对语音的研究可能会对这些基本问题有所帮助。先前的研究表明，上级颞叶皮层在处理语音，但很少有人知道这些声音是如何连接在一起，形成对单词和连续语音的感知体验。神经活动的记录直接从皮层表面是一种很有前途的研究方法，因为它可以提供高的空间和时间分辨率这项建议旨在研究机制的语音编码，利用在神经外科手术过程中获得的神经生理学记录。高密度电极阵列和先进的信号处理将被用来解开本地和人口编码的语音声音，外侧颞叶皮层总的目标是确定大脑如何从一个语言中提取语言元素。复杂的声学语音信号，以更好地理解和补救人类语言障碍。

项目成果

期刊论文数量（50）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Dissecting neural computations in the human auditory pathway using deep neural networks for speech.

DOI：
10.1038/s41593-023-01468-4
发表时间：
2023-12
期刊：
NATURE NEUROSCIENCE
影响因子：
25
作者：
Li, Yuanning;Anumanchipalli, Gopala K.;Mohamed, Abdelrahman;Chen, Peili;Carney, Laurel H.;Lu, Junfeng;Wu, Jinsong;Chang, Edward F.
通讯作者：
Chang, Edward F.

Intact speech perception after resection of dominant hemisphere primary auditory cortex for the treatment of medically refractory epilepsy: illustrative case.

切除优势半球初级听觉皮层以治疗难治性癫痫后完整的言语感知：说明性案例。

DOI：
10.3171/case22417
发表时间：
2022
期刊：
Journal of neurosurgery. Case lessons
影响因子：
0
作者：
Hullett,PatrickW;Kandahari,Nazineen;Shih,TinaT;Kleen,JonathanK;Knowlton,RobertC;Rao,VikramR;Chang,EdwardF
通讯作者：
Chang,EdwardF

Neural correlates of sine-wave speech intelligibility in human frontal and temporal cortex.

人类额叶和颞叶皮层正弦波语音清晰度的神经相关性。