The Impact of Social, Genetic and Neuroimaging Factors on Cognitive Functioning in the Black Community

社会、遗传和神经影像因素对黑人社区认知功能的影响

• 批准号: 10664484
• 负责人: Kacie Deters
• 金额: $ 21.47万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-15 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664484
• 关键词: Admixture; Affect; African; African American; African ancestry; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Apolipoprotein E; Area; Biological; Biological Markers; Biology; Birth; Black American; Black Populations; Black race; Blood Vessels; Brain; Brain region; Clinical; Cognition; Cognitive; Cognitive aging; Communities; Competence; County; Data; Dementia; Disease; Education; Enrollment; European ancestry; Fathers; Future; Genes; Genetic; Goals; Heterogeneity; Impaired cognition; Impairment; Income; Individual; Knowledge; Life; Life Cycle Stages; Location; Longevity; Los Angeles; Magnetic Resonance Imaging; Measures; Mediating; Memory; Mentored Research Scientist Development Award; Mentors; Mentorship; Methodology; Minority; Mothers; Nerve Degeneration; Neuropsychological Tests; Neuropsychology; Not Hispanic or Latino; Participant; Pathologic; Population; Population Heterogeneity; Populations at Risk; Positioning Attribute; Prevention; Race; Research; Research Personnel; Risk; Risk Factors; Science; Socioeconomic Status; Symptoms; Testing; Training; Training Activity; Variant; White Matter Hyperintensity; apolipoprotein E-4; biological heterogeneity; brain health; childhood adversity; cognitive function; cohort; community engagement; disparity reduction; ethnic disparity; experience; genetic risk factor; health disparity; high risk; member; mild cognitive impairment; multidisciplinary; neighborhood disadvantage; neural correlate; neurocognitive test; neuroimaging; neuroimaging marker; non-demented; perceived discrimination; prevent; racial disparity; racial population; research study; risk prediction; skills; social; social disparities; social factors; tool

PROJECT SUMMARY The applicant seeks this K01 award to gain expertise on integrating social factors and neuropsychological assessments to examine within race heterogeneity for cognitive decline risk factors in the Black community. To achieve these goals, the applicant plans to leverage her strength is quantitative methodology for biomarker data to gain expertise in four critical areas of training: (1) research neuropsychological testing and community engagement; (2) health disparities and lifecourse factors; (3) genetics; and (4) professional training. With the guidance from her expert mentorship team and through a detailed training plan, the applicant will develop an in-depth knowledge in these training areas and enable the applicant to be well positioned to successfully complete the proposed aims of the K01. The overall research goal of this K01 application is to determine how social, neuroimaging markers, and genetic risk factors contribute to cognitive decline in non-demented older Black individuals. Research suggests current “well-established” risk factors for cognitive decline and Alzheimer’s disease (AD), which have been identified primarily in the white community, do not behave the same in Black individuals. Thus, it is critical to explore potential heterogeneity in risk factors within the Black community in order to accurately predict risk for cognitive decline. The first part of aim 1 examines the effect of early and current social factors on neuroimaging measures that have previously been associated with cognition (e.g. structural magnetic resonance imaging measures and vascular burden measured as white matter hyperintensities) in self-identified non-Hispanic Black participants. The second part of aim 1 will determine if these neuroimaging markers mediate the association of social factors and cognitive decline. We hypothesize that more social disadvantage will be inversely associated with AD-specific brain regions and faster rates of cognitive decline. We also hypothesize that neuroimaging measures will partially mediate the association of social factors on cognitive decline. Differences in racial groups may be due to social factors, which members of the Black community are disproportionately impacted. Finally, it is important to remember that race is a social construct and is dependent on self-identification, with no biological root. Moreover, recent studies suggest that genetic ancestry may influence risk for AD and impact pathological features of aging. It is unclear if genetic ancestry and social factors correlate, or if they have unique contributions to cognitive decline. Thus, our final aim will determine if genetic ancestry and/or social factors differentially influence the effect of APOE4 on cognitive decline. The primary hypothesis is that Black participants with more social disadvantage throughout life, will inversely effect these risk factors and have a faster rate of cognitive decline. We will also investigate if this association impacts conversion from mild cognitive impairment to AD dementia. Completion of these aims, along with the training from an experienced multidisciplinary mentoring team, will generate data and support for a future R01 application collecting data from members of the Black community in Los Angeles County.

项目摘要 申请人寻求这个K 01奖，以获得整合社会因素和神经心理学的专业知识。 评估以检查黑人社区中认知能力下降风险因素的种族异质性。到 为了实现这些目标，申请人计划利用她的优势是生物标志物的定量方法学。 数据，以获得培训的四个关键领域的专业知识：（1）研究神经心理测试和社区 参与;（2）健康差异和生命过程因素;（3）遗传学;（4）专业培训。与 在她的专家指导团队的指导下，通过详细的培训计划，申请人将制定一个 在这些培训领域的深入知识，使申请人能够成功地 完成K 01的目标。此K 01应用程序的总体研究目标是确定如何 社会、神经影像学标记物和遗传风险因素导致非痴呆老年人认知能力下降 黑人研究表明，目前认知能力下降的“公认”风险因素， 阿尔茨海默氏病（AD）主要在白色人群中发现， 黑人也是如此。因此，关键是要探索黑人中危险因素的潜在异质性。 为了准确预测认知能力下降的风险。目标1的第一部分审查了 早期和当前的社会因素对神经影像学测量的影响， (e.g.结构磁共振成像测量和血管负荷测量为白色物质 高强度）在自我认定的非西班牙裔黑人参与者中。目标1的第二部分将确定， 这些神经成像标记物介导社会因素和认知能力下降的关联。我们假设 更多的社会劣势将与AD特异性大脑区域和更快的 认知能力下降我们还假设，神经影像学措施将部分介导的关联， 社会因素对认知能力下降的影响种族群体的差异可能是由于社会因素， 黑人社区受到不成比例的影响。最后，重要的是要记住，种族是一种社会 它依赖于自我认同，没有生物学根源。此外，最近的研究表明， 遗传祖先可能影响AD的风险并影响衰老的病理特征。目前尚不清楚是否遗传 祖先和社会因素相关，或者他们对认知能力下降有独特的贡献。因此，我们的最终 目的是确定遗传祖先和/或社会因素是否对APOE 4的作用有不同的影响， 认知能力下降主要假设是，黑人参与者在整个社会中处于更不利的地位。 生活，将对这些风险因素产生相反的影响，并且认知能力下降的速度更快。我们还将调查， 这种关联影响从轻度认知损害到AD痴呆的转化。完成这些目标， 沿着经验丰富的多学科指导团队的培训，将为以下方面提供数据和支持： 未来的R 01应用程序从洛杉矶县的黑人社区成员收集数据。