Long-wavelength 1.7-micron optical coherence tomography for otologic imaging and hearing research

用于耳科成像和听力研究的长波长 1.7 微米光学相干断层扫描

• 批准号: 10664863
• 负责人: Jack Chong Wu Tang
• 金额: $ 7.43万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664863
• 关键词: Adult; Affect; Animal Model; Animals; Apical; Area; Blood flow; CBA/CaJ Mouse; Cadaver; Calibration; Cells; Cholesteatoma; Clinic; Clinical; Cochlea; Collaborations; Collection; Computer software; Custom; Data; Devices; Diagnosis; Emergency Situation; Etiology; External auditory canal; Fiber Optics; Functional Imaging; Hearing; Hearing problem; Human; Image; Imaging Device; Imaging technology; Impairment; Labyrinth; Lasers; Lateral; Light; Location; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Meniere' s Disease; Metabolic; Methods; Morphology; Motion; Mus; Noise-Induced Hearing Loss; Optical Coherence Tomography; Organ of Corti; Otitis Media; Otology; Otosclerosis; Otoscopes; Pathology; Penetration; Phase; Physiological; Preparation; Presbycusis; Quality of life; Research; Research Personnel; Resolution; Sampling; Scanning; Sensorineural Hearing Loss; Signal Transduction; Source; Stria Vascularis; Structure; Surface; System; Technology; Testing; Therapeutic; Time; Tissues; Traction; Tympanic Membrane Perforation; Tympanic membrane; United States; Vascularization; Volunteer Group; X-Ray Computed Tomography; animal imaging; arm; awake; capsule; clinical imaging; effective therapy; ex vivo imaging; handheld equipment; hearing impairment; high resolution imaging; human tissue; imaging approach; improved; in vivo; light scattering; meter; middle ear; millimeter; nanometer; non-invasive imaging; optical fiber; recruit; round window; soft tissue; sound frequency; structural imaging; tool; vibration

PROJECT SUMMARY/ABSTRACT Hearing loss affects the quality of life in nearly one-in-four adults in the United States, yet in many cases it is difficult to identify the cause. CT imaging can provide high-resolution contrast in the small bony structures in the middle/inner ear, and MRI can provide medium-resolution contrast in soft tissues, but there exists a need for high-resolution imaging of the soft cochlear tissues. Optical coherence tomography (OCT) is one technology that can fill this need and is gaining traction as a potential method for non-invasive otologic imaging due to its ability to record high-resolution volumetric images, blood flow, and vibrations through several millimeters of tissue. These advantages have also made OCT a popular tool in basic hearing research. Cochlear blood flow is a particularly useful metric to quantify since animal models of noise-induced hearing loss, and cadaveric studies of age-related hearing loss have identified impaired cochlear blood flow as part of their etiology. Vibrometry is another useful metric since in-vivo measurements of cochlear tuning and gain are being used to investigate cochlear mechanics in animal models. However, current OCT systems operating at 1.3 μm are limited in their ability to penetrate the bony otic capsule in humans, and also into the basal turn of the mouse cochlea. Extending the imaging depth of OCT may enable collection of blood flow and vibrometry data from physiologically important locations, such as the stria vascularis in humans and the basal turn of the mouse cochlea, which have been difficult to image using 1.3 µm OCT. Therefore, we aim to develop long- wavelength 1.7 μm OCT systems that will enable deeper imaging due to reduced tissue scattering at 1.7 µm. We aim to develop a handheld OCT otoscope device for non-invasive clinical imaging and blood flow quantification in the human cochlea via the ear canal. This may enable the first non-invasive measurements of cochlear blood flow in humans. We also aim to develop a benchtop stereomicroscope OCT system operating at 1.7 μm to enable OCT vibrometry in the basal turn of the mouse cochlea, where documented differences in cochlear mechanics remain to be explored. Completion of this project will result in the creation of new imaging devices for the otology clinic and for basic hearing research.

项目总结/摘要 听力损失影响美国近四分之一成年人的生活质量，但在许多情况下， 很难确定原因。CT成像可以提供高分辨率的对比度，在小骨结构， 中耳/内耳，MRI可以在软组织中提供中等分辨率的对比度，但仍需要 用于软耳蜗组织的高分辨率成像。光学相干断层扫描（OCT）是一种 一种可以满足这一需求的技术，作为一种潜在的非侵入性耳科成像方法， 由于其能够记录高分辨率的体积图像、血流和通过几个通道的振动， 几毫米的组织这些优点也使OCT成为基础听力研究中的流行工具。 自从噪音诱导听力的动物模型以来，耳蜗血流是一个特别有用的量化指标 与年龄相关的听力损失的尸体研究已经确定耳蜗血流受损是听力损失的一部分。 其病因。振动测量法是另一个有用的度量，因为耳蜗调谐和增益的体内测量是 用于研究动物模型中的耳蜗力学。然而，目前的OCT系统在 1.3μm在穿透人的骨性耳囊以及进入耳的基弯的能力方面是有限的。 小鼠耳蜗。扩展OCT的成像深度可以实现血流和振动测量的收集 来自生理学上重要位置的数据，例如人体中的血管纹和 小鼠耳蜗，使用1.3 µm OCT难以成像。因此，我们的目标是开发长- 波长为1.7 μm的OCT系统，由于在1.7 μm处减少了组织散射，因此能够实现更深的成像。 我们的目标是开发一种手持式OCT耳镜设备，用于非侵入性临床成像和血流 通过耳道在人类耳蜗中进行量化。这可以使得能够进行第一次非侵入性测量， 人类耳蜗的血流。我们还旨在开发一种台式体视显微镜OCT系统， 在1.7 μm处进行OCT振动测量，以在小鼠耳蜗的基底圈中进行OCT振动测量，其中记录了 耳蜗力学仍有待探索。该项目的完成将导致创建新的成像 用于耳科诊所和基础听力研究的设备。