Long-wavelength 1.7-micron optical coherence tomography for otologic imaging and hearing research

用于耳科成像和听力研究的长波长 1.7 微米光学相干断层扫描

• 批准号: 10664863
• 负责人: Jack Chong Wu Tang
• 金额: $ 7.43万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664863
• 关键词: Adult; Affect; Animal Model; Animals; Apical; Area; Blood flow; CBA/CaJ Mouse; Cadaver; Calibration; Cells; Cholesteatoma; Clinic; Clinical; Cochlea; Collaborations; Collection; Computer software; Custom; Data; Devices; Diagnosis; Emergency Situation; Etiology; External auditory canal; Fiber Optics; Functional Imaging; Hearing; Hearing problem; Human; Image; Imaging Device; Imaging technology; Impairment; Labyrinth; Lasers; Lateral; Light; Location; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Meniere' s Disease; Metabolic; Methods; Morphology; Motion; Mus; Noise-Induced Hearing Loss; Optical Coherence Tomography; Organ of Corti; Otitis Media; Otology; Otosclerosis; Otoscopes; Pathology; Penetration; Phase; Physiological; Preparation; Presbycusis; Quality of life; Research; Research Personnel; Resolution; Sampling; Scanning; Sensorineural Hearing Loss; Signal Transduction; Source; Stria Vascularis; Structure; Surface; System; Technology; Testing; Therapeutic; Time; Tissues; Traction; Tympanic Membrane Perforation; Tympanic membrane; United States; Vascularization; Volunteer Group; X-Ray Computed Tomography; animal imaging; arm; awake; capsule; clinical imaging; effective therapy; ex vivo imaging; handheld equipment; hearing impairment; high resolution imaging; human tissue; imaging approach; improved; in vivo; light scattering; meter; middle ear; millimeter; nanometer; non-invasive imaging; optical fiber; recruit; round window; soft tissue; sound frequency; structural imaging; tool; vibration

PROJECT SUMMARY/ABSTRACT Hearing loss affects the quality of life in nearly one-in-four adults in the United States, yet in many cases it is difficult to identify the cause. CT imaging can provide high-resolution contrast in the small bony structures in the middle/inner ear, and MRI can provide medium-resolution contrast in soft tissues, but there exists a need for high-resolution imaging of the soft cochlear tissues. Optical coherence tomography (OCT) is one technology that can fill this need and is gaining traction as a potential method for non-invasive otologic imaging due to its ability to record high-resolution volumetric images, blood flow, and vibrations through several millimeters of tissue. These advantages have also made OCT a popular tool in basic hearing research. Cochlear blood flow is a particularly useful metric to quantify since animal models of noise-induced hearing loss, and cadaveric studies of age-related hearing loss have identified impaired cochlear blood flow as part of their etiology. Vibrometry is another useful metric since in-vivo measurements of cochlear tuning and gain are being used to investigate cochlear mechanics in animal models. However, current OCT systems operating at 1.3 μm are limited in their ability to penetrate the bony otic capsule in humans, and also into the basal turn of the mouse cochlea. Extending the imaging depth of OCT may enable collection of blood flow and vibrometry data from physiologically important locations, such as the stria vascularis in humans and the basal turn of the mouse cochlea, which have been difficult to image using 1.3 µm OCT. Therefore, we aim to develop long- wavelength 1.7 μm OCT systems that will enable deeper imaging due to reduced tissue scattering at 1.7 µm. We aim to develop a handheld OCT otoscope device for non-invasive clinical imaging and blood flow quantification in the human cochlea via the ear canal. This may enable the first non-invasive measurements of cochlear blood flow in humans. We also aim to develop a benchtop stereomicroscope OCT system operating at 1.7 μm to enable OCT vibrometry in the basal turn of the mouse cochlea, where documented differences in cochlear mechanics remain to be explored. Completion of this project will result in the creation of new imaging devices for the otology clinic and for basic hearing research.

项目摘要/摘要 听力损失会影响美国近四分之一成年人的生活质量，但在许多情况下是 难以识别原因。 CT成像可以在小奖金结构中提供高分辨率对比 中耳/内耳和MRI可以在柔软的时机中提供中半分辨率的对比，但存在 用于对软系组织的高分辨率成像。光学相干断层扫描（OCT）是一个 可以满足这一需求并作为非侵入性耳诺成像的潜在方法而获得吸引力的技术 由于它能够记录高分辨率体积图像，血流和通过几个 组织的毫米。这些优势也使OCT成为基本听力研究的流行工具。 耳蜗血流是量化的特别有用的指标，因为噪声引起的听力模型 损失和与年龄相关的听力损失的尸体研究已经确定了耳蜗血流受损的一部分 他们的病因。振动法是另一个有用的指标，因为耳蜗调整和增益的体内测量 用于研究动物模型中的人工耳蜗。但是，当前的OCT系统在 1.3μm的限制是其穿透人类骨质胶囊的能力，也有限 小鼠耳蜗。扩展OCT的成像深度可能会促进血流和振动的收集 来自物理上重要位置的数据，例如人类中的Stria Vascularis和 小鼠耳蜗很难使用1.3 µm OCT进行成像。因此，我们旨在发展长期 波长为1.7μmOCT系统，该系统将由于减少的组织散射在1.7μm时能够更深的成像。 我们旨在开发用于非侵入性临床成像和血流的手持式OCT耳镜设备 通过耳道在人耳蜗中进行定量。这可能使第一个非侵入性测量值 人类的人工血流在人类中。我们还旨在开发台式立体显微镜OCT系统运行 在1.7μm处，在小鼠耳蜗的基本转弯中启用OCT振动法，其中有记录的差异 人工耳蜗仍有待探索。该项目的完成将导致创建新成像 耳鼻喉科诊所和基本听力研究的设备。