Institutional Career Development Core (KL2)

机构职业发展核心（KL2）

• 批准号: 10664852
• 负责人: STEVEN M. ASCH
• 金额: $ 171.07万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664852
• 关键词: Academia; Address; Appointment; Area; Attitude; Biomedical Research; Clinical Medicine; Clinical Research; Communities; Competence; Development; Development Plans; Education; Elements; Enrollment; Evaluation; Faculty; Funding; Future; Good Clinical Practice; Government; Grant; Individual; Industry; Institution; Instruction; Knowledge; Knowledge acquisition; Leadership; Life Cycle Stages; Longevity; Manuscripts; Mentors; National Center for Advancing Translational Sciences; Positioning Attribute; Prevention; Reproducibility; Research; Research Ethics; Science; Thinking; Training; Training Programs; Translational Research; career; career development; design; improved; innovation; medical specialties; population health; programs; skills; translational medicine; translational pipeline

The core objective of this heavily revised and re-invigorated Stanford CTSA-associated KL2 program is to provide high-quality personalized training in clinical and translational research and education (CTRE) to junior faculty. Training will encompass the entire translational spectrum from T0-1 to T4, irrespective of the individual Scholar’s current research focus. At the completion of their training, these young “CTR” Scholars will have acquired the knowledge, skills, and attitudes necessary to address impactful questions, author grants and manuscripts, compete effectively for external funding, develop mentoring and team building strategies, and understand how to develop and follow their career development plans. We aim to enable our Scholars to excel at their research-based positions in academia and also in government, not-for-profit, and industry-based biomedical research enterprises. We expect that the research careers of our Scholars will be focused on innovation, discovery, implementation, and dissemination of new knowledge, a longstanding Stanford tradition. Specific components will include: • Didactic instruction embedded within a degree opportunity or a more customized selection of courses • A multi-faceted mentoring program, starting with a Career Development Plan, that will meld the perspectives of research mentors with the career mentors and KL2 leadership • A professional development core, organized to cover all topics and competencies identified by NCATS and the CTSAs as central to CTR including research ethics, research reproducibility, compliance, and good clinical practice • Training in team science, community-engaged participatory research, and regulatory sciences within a comprehensive life-course framework. Stanford KL2 appointments will be for two years. We are applying for 4 or 5 new positions per year to result in nine enrolled KL2 Scholars in our training program at steady state. All future Scholars will be on a confirmed path to become Stanford junior faculty. Rigorous short-, medium-, and long-term metrics for evaluations of trainees and the program itself, are designed to assure continuous improvement. Our newly reframed KL2 program will emphasize teamwork and elements of design-based thinking, under the premise that clinical and translational medicine at all stages is a coherent scientific specialty that bridges all disciplinary areas, spanning the life course, from the discovery of targets for treatment and prevention to effecting change at the bedside and advancing the health of populations.

这个经过大量修订和重新修订的斯坦福大学CTSA相关KL 2计划的核心目标是 提供高质量的临床和转化研究和教育（CTRE）的个性化培训，以初级 教师。培训将涵盖从T0-1到T4的整个翻译范围，无论个人如何 学者目前的研究重点。在完成培训后，这些年轻的“CTR”学者将拥有 获得了解决有影响力的问题所需的知识，技能和态度，作者赠款金， 手稿，有效地争取外部资金，制定指导和团队建设战略，以及 了解如何制定和遵循他们的职业发展计划。我们的目标是使我们的学者脱颖而出 在他们的研究为基础的立场，在学术界，也在政府，不以营利为目的，和工业为基础的 生物医学研究企业。我们希望我们的学者的研究生涯将集中在 创新、发现、实施和传播新知识，这是斯坦福大学的悠久传统。 具体内容将包括： ·嵌入学位机会或更定制的课程选择中的教学指导 ·一个多方面的指导计划，从职业发展计划开始，将融合 研究导师与职业导师和KL 2领导层的观点 ·专业发展核心，组织起来涵盖所有主题和能力， NCATS和CTSA是CTR的核心，包括研究伦理，研究再现性， 合规性和良好临床实践 ·团队科学，社区参与式研究和监管科学的培训 全面的生命历程框架。 斯坦福大学KL 2的任期为两年。我们每年申请4或5个新职位， 结果在我们的培训计划在稳定状态九个注册KL 2学者。所有未来的学者将在一个 成为斯坦福大学初级教师的途径。严格的短期、中期和长期指标， 对受训人员和方案本身的评估旨在确保持续改进。我们新 重新设计的KL 2课程将强调团队合作和基于设计的思维元素，前提是 所有阶段的临床和转化医学是一个连贯的科学专业，连接所有学科领域， 从发现治疗和预防的目标到在生命周期中实现改变， 床旁和促进人民的健康。

项目成果

Ex Vivo Modeling of Atrioventricular Valve Mechanics in Single Ventricle Physiology.

单心室生理学中房室瓣力学的离体建模。

• DOI: 10.1007/s10439-023-03178-1
• 发表时间: 2023
• 期刊: Annals of biomedical engineering
• 影响因子: 3.8
• 作者: Moye,StephenC;Kidambi,Sumanth;Lee,JamesY;Cowles,TeaghanH;Gilligan-Steinberg,ShaneD;Bryan,AmeliaY;Wilkerson,Rob;Woo,YJoseph;Ma,MichaelR
• 通讯作者: Ma,MichaelR

Health and Economic Outcomes of Posterior Spinal Fusion for Children With Neuromuscular Scoliosis.

神经肌肉脊柱侧凸儿童后路脊柱融合术的健康和经济成果。

• DOI: 10.1542/hpeds.2019-0153
• 发表时间: 2020
• 期刊: Hospital pediatrics
• 作者: Lin,JodyL;Tawfik,DanielS;Gupta,Ribhav;Imrie,Meghan;Bendavid,Eran;Owens,DouglasK
• 通讯作者: Owens,DouglasK

Cervical Cancer Screening in Low- and Middle-Income Countries-Reply.

低收入和中等收入国家的宫颈癌筛查-答复。

• DOI: 10.1001/jama.2020.25217
• 发表时间: 2021
• 期刊: JAMA
• 作者: Geldsetzer,Pascal;Lemp,JuliaM
• 通讯作者: Lemp,JuliaM

Curbing the COVID-19 pandemic with facility-based isolation of mild cases: a mathematical modeling study.

• DOI: 10.1093/jtm/taaa226
• 发表时间: 2021-02-23
• 期刊: Journal of travel medicine
• 影响因子: 25.7
• 作者: Chen S;Chen Q;Yang J;Lin L;Li L;Jiao L;Geldsetzer P;Wang C;Wilder-Smith A;Bärnighausen T
• 通讯作者: Bärnighausen T

Implications of Extra-cardiac Disease in Patient Selection for Heart Transplantation: Considerations in Cardiac Amyloidosis.

• DOI: 10.15420/cfr.2022.24
• 发表时间: 2023-02
• 期刊: CARDIAC FAILURE REVIEW
• 作者: Punnoose, Lynn Raju;Siddiqi, Hasan;Rosenthal, Julie L.;Kittleson, Michelle;Witteles, Ronald;Alexander, Kevin
• 通讯作者: Alexander, Kevin