Translational Research Center for TBI and Stress Disorders (TRACTS)

TBI 和应激障碍转化研究中心 (TRACTS)

• 批准号: 10664963
• 负责人: Catherine Brawn Fortier
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664963
• 关键词: Address; Anxiety Disorders; Area; Back; Behavior; Biological; Biology; Boston; Brain Injuries; Center for Translational Science Activities; Clinical; Clinical Research; Communities; Complex; Development; Diagnostic; Education; Elderly; Ensure; Environment; Epidemiology; Exposure to; Family; Fostering; Freedom; Funding; Glean; Goals; Health; Healthcare Systems; Home; Individual; Infrastructure; Injury; Internships; Knowledge; Life; Long-Term Effects; Longitudinal Studies; Longitudinal cohort study; Medical; Medical center; Mental Health; Mentors; Minority; Mission; Mood Disorders; Multiple Trauma; Nature; Neurobiology; Neuropsychology; Neurosciences Research; Phenotype; Population; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Rehabilitation therapy; Research; Research Personnel; Resources; Risk; Severities; Site; Societies; Substance Use Disorder; Symptoms; Therapeutic; Training; Training and Education; Trauma; Traumatic Brain Injury; Universities; Veterans; War; Work; chronic pain; clinical training; cohort; data repository; effective therapy; endophenotype; experience; functional decline; graduate student; innovation; loved ones; mild traumatic brain injury; multidisciplinary; neuropsychiatry; next generation; operation; outreach; physical conditioning; post 9/11; programs; prospective; psychoeducation; psychoeducational; psychologic; rehabilitation research; rehabilitation strategy; sleep syndrome; stress disorder; stress related disorder; training opportunity; undergraduate student

The VA RR&D TBI National Network Research Center based at VA Boston Healthcare System, with a network site at the Michael E. DeBakey VA Medical Center, called the Translational Research Center for TBI and Stress Disorders (TRACTS) (funded initially in 2009) proposes to continue its mission of conducting multidisciplinary, clinical research aimed at providing a psychological, biological and neurobiological characterization of the effects of traumatic brain injury (TBI) and related stress disorders, and to use this understanding to create effective treatment opportunities for Veterans of Operation Enduring Freedom, Operation Iraqi Freedom, and Operation New Dawn (OEF/OIF/OND). Over the last funding period, TRACTS has made remarkable progress in understanding the synergistic effect of mild traumatic brain injury (mTBI) and exposure to blast munitions on the mental and physical health of Veterans. This foundational work, which holistically has integrated psychological, biological, and epidemiological approaches to the study of the long- term effects of brain injury incurred during war, has led to the emerging concept of “Deployment Trauma” (DT) and helped create a roadmap toward the treatment and rehabilitation of the complex and interacting issues that define the civilian experience of Veterans in the post 9/11 era. It is our overarching goal and unifying mission to identify, understand, and treat the long-term effects of deployment trauma in our post 9/11 Veterans. Over the next funding period, the TRACTS infrastructure will be used to continue to grow and maintain the TRACTS cohort and the TRACTS prospective longitudinal cohort study, as well as the resultant TRACTS Data Repository. In the current application, we propose to investigate three interlocking Focus Areas (FA) that speak to critical gaps in our knowledge that must be addressed if we are to be successful in reaching our goals. These focus areas build upon our foundational observations over the last 8+ years and use this evolving wealth of information regarding the clinical presentation and endophenotypes of deployment trauma in OEF/OIF/OND Veterans to develop rehabilitative treatments that will foster civilian reintegration and reduce psychological and medical symptom severity. The three focus areas are: FA1: Deep phenotyping of DT and its functional consequences; FA 2: Understanding the dynamic interplay between biology and behavior that determines the biological and functional consequences of DT; FA 3: Rehabilitation and treatment of the functional and neurobiological consequences of DT. TRACTS will continue in its mission to provide the next generation of VA researchers with an innovative and outstanding mentoring environment at both the VA Boston and Houston Medical Centers through training in assessment, and rehabilitation and clinical neuroscience research. Our affiliations with other programs within VA, such as the National Centers for PTSD, MAVERIC, PTSD/TBI Brain Bank, as well as our affiliated universities, ensure that we have rich resources for excellence in training opportunities for undergraduates, graduate students, neuropsychology interns and post docs, and geriatric, neuropsychiatry and polytrauma fellows. Finally, TRACTS has initiated a wide-ranging education, outreach and dissemination effort intended to reach a broad audience of researchers, clinicians, Veterans and their families. This effort has included the provision of clinical training/education on the clinical complexities and idiosyncrasies of the OEF/OIF/OND population to researchers and clinicians, development of collaborative relationships within the greater Boston and Houston communities, and provide psychoeducation and resources to returning Veterans and their loved ones. In sum, TRACTS is well poised to continue its cutting-edge work over the next five years. The knowledge gleaned from the neuroscience and rehabilitation research conducted at TRACTS will continue to fill current gaps in diagnostics and therapeutics for Veterans with mTBI, blast, and stress-related disorders.

VA RR & D TBI国家网络研究中心位于VA波士顿医疗保健系统， 在Michael E. DeBakey VA医疗中心，称为TBI转化研究中心， 应激障碍（TRACTS）（最初于2009年获得资助）建议继续其使命， 多学科的临床研究，旨在提供一个心理，生物和神经生物学 描述创伤性脑损伤（TBI）和相关应激障碍的影响，并使用此 理解为持久自由行动的退伍军人创造有效的治疗机会， 新黎明行动（OEF/OIF/OND）。在上一个供资期间，TRACTS 在理解轻度创伤性脑损伤（mTBI）的协同作用方面取得了显着进展， 暴露于爆炸弹药对退伍军人的身心健康的影响。这项基础性工作， 从整体上综合了心理学，生物学和流行病学的方法来研究长期的， 战争期间脑损伤的长期影响，导致了“部署创伤”（DT）的概念出现 并帮助制定了一个治疗和康复复杂和相互作用的问题的路线图， 定义退伍军人在后9/11时代的平民经历。这是我们的首要目标， 使命是识别、理解和治疗9/11事件后部署创伤的长期影响 老兵在下一个融资期内，TRACTS基础设施将用于继续增长， 维持TRACTS队列和TRACTS前瞻性纵向队列研究，以及由此产生的 TRACTS数据存储库。在当前的应用中，我们建议调查三个相互关联的重点领域 (FA)这说明了我们知识中的关键差距，如果我们要成功地实现 我们的目标这些重点领域建立在我们过去8年多的基本观察基础上， 关于展开创伤的临床表现和内表型的丰富信息， * 持久自由行动/法语国家组织/布隆迪观察团退伍军人发展康复治疗，促进平民重返社会， 心理和医学症状的严重程度。这三个重点领域是：FA1：DT的深层表型及其 功能后果; FA 2：理解生物学和行为之间的动态相互作用， 确定DT的生物学和功能后果; FA 3： DT的功能和神经生物学后果。 TRACTS将继续其使命，为下一代VA研究人员提供创新和 通过培训，在VA波士顿和休斯顿医疗中心提供出色的指导环境， 评估、康复和临床神经科学研究。我们与其他项目的联系 VA，如国家创伤后应激障碍中心，MAVERIC，创伤后应激障碍/TBI脑库，以及我们的附属机构 大学，确保我们有丰富的资源，为本科生提供卓越的培训机会， 研究生，神经心理学实习生和博士后，以及老年病，神经精神病学和多发性创伤 伙计们 最后，旅游景点跟踪服务机构还发起了一项广泛的教育、外联和传播工作，目的是使 研究人员、临床医生、退伍军人及其家属的广泛受众。这一努力包括提供 关于OEF/OIF/OND人群临床复杂性和特异性的临床培训/教育， 研究人员和临床医生，在大波士顿和休斯顿发展合作关系 社区，并提供心理教育和资源，以返回退伍军人和他们的亲人。 总之，TRACTS已做好准备，在今后五年继续开展其尖端工作。知识 从TRACTS进行的神经科学和康复研究中收集的信息将继续填补目前的空白。 患有mTBI、爆炸和应激相关疾病的退伍军人的诊断和治疗方面存在差距。

项目成果

Childhood trauma differentially impacts depression and stress associations with reintegration challenges among post-9/11 U.S. veterans.

童年创伤对 9/11 事件后美国退伍军人的抑郁和压力与重返社会挑战的影响存在差异。

• DOI: 10.1016/j.outlook.2021.10.008
• 发表时间: 2022
• 期刊: Nursing outlook
• 影响因子: 4.3
• 作者: Etchin,AnnaG;Fonda,JenniferR;Howard,ElizabethP;Fortier,CatherineB;Milberg,WilliamP;Pounds,Karen;McGlinchey,ReginaE
• 通讯作者: McGlinchey,ReginaE

Reporting of symptoms associated with concussion by OEF/OIF/OND Veterans: Comparison between research and clinical contexts.

OEF/OIF/OND 退伍军人报告与脑震荡相关的症状：研究与临床背景之间的比较。

• DOI: 10.1080/02699052.2017.1280740
• 发表时间: 2017
• 期刊: Brain injury
• 影响因子: 1.9
• 作者: Jackson,ColleenE;Nordstrom,Leslie;Fonda,JenniferR;Fortier,CatherineB;Milberg,WilliamP;McGlinchey,ReginaE
• 通讯作者: McGlinchey,ReginaE

Associations between Post-Traumatic stress disorder symptoms and automobile driving behaviors: A review of the literature.

创伤后应激障碍症状与汽车驾驶行为之间的关联：文献综述。

• DOI: 10.1016/j.aap.2022.106648
• 发表时间: 2022-06
• 期刊: ACCIDENT ANALYSIS AND PREVENTION
• 影响因子: 5.9
• 作者: Bernstein, John P. K.;Milberg, William P.;McGlinchey, Regina E.;Fortier, Catherine B.
• 通讯作者: Fortier, Catherine B.

Elevated rates of memory impairment in military service-members and veterans with posttraumatic stress disorder.

患有创伤后应激障碍的军人和退伍军人的记忆障碍率升高。

• DOI: 10.1080/13803395.2016.1264575
• 发表时间: 2017
• 期刊: Journal of clinical and experimental neuropsychology
• 影响因子: 2.2
• 作者: Stricker,NikkiH;Lippa,SaraM;Green,DeborahL;McGlynn,SusanM;Grande,LauraJ;Milberg,WilliamP;McGlinchey,ReginaE
• 通讯作者: McGlinchey,ReginaE

Intimate Partner Violence Predicts Posttraumatic Stress Disorder Severity Independent of Early Life and Deployment-Related Trauma in Deployed Men and Women Veterans.

亲密伴侣暴力可以预测退役男女退伍军人的创伤后应激障碍严重程度，与早年生活和服役相关创伤无关。

• DOI: 10.1177/0886260520938514
• 发表时间: 2022
• 期刊: Journal of interpersonal violence
• 影响因子: 2.5
• 作者: Pierce,MeghanE;Fortier,Catherine;Fonda,JenniferR;Milberg,William;McGlinchey,Regina
• 通讯作者: McGlinchey,Regina