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Associative learning and brain structure in individuals at risk for dementia

有痴呆风险的个体的联想学习和大脑结构

基本信息

批准号：
8667382
负责人：
Catherine Brawn Fortier
金额：
$ 15.65万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-01 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8667382
关键词：
Address Adult Age Age-associated memory impairment Aging Aging-Related Process Alcoholism Alleles Alzheimer&apos s Disease Alzheimer&apos s disease risk Amnesia Anatomy Animals Apolipoproteins Area Behavior Behavioral Blinking Blood Glucose Brain Brain imaging Brain region Calculi Cerebrovascular Disorders Cholesterol Classification Clinical Cognition Cognition Disorders Cognitive Complex Conditioned Stimulus Cues Dementia Development Diabetes Mellitus Diagnosis Diffusion Magnetic Resonance Imaging Discrimination Discrimination Learning Disease Dissociation Elderly Ensure Environment Epidemiology Episodic memory Genetic Genetic Risk Health Transition Hippocampus (Brain)Histopathology Hypertension Image Impairment Individual Instruction Investigation Learning Life Link Magnetic Resonance Imaging Maps Measurable Measures Medial Memory Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Methodology Nature Neurobiology Neurologic Neuropsychological Tests Neuropsychology Patients Pattern Performance Phase Physiological Population Preparation Process Prosencephalon Research Research Project Grants Research Training Resources Reversal Learning Risk Risk Factors Stimulus Structure Structure-Activity Relationship System Techniques Temporal Lobe Time Training Variant Vascular Dementia age related career classical conditioning cognitive change cognitive neuroscience conditioning disorder risk executive function follow-up frontal lobe gray matter hypercholesterolemia middle age morphometry neuroimaging neuropsychological relating to nervous system response skills stem white matter

项目摘要

DESCRIPTION (provided by applicant): This application for a Mentored Patient-Oriented Research Career Development Award (K23) is intended to provide specific skills and mentorship to the candidate in complementary and integrative areas of cognitive neuroscience in preparation for an independent research career. This proposal describes a comprehensive five- year training plan focused on expanding the candidate's skills and developing expertise in the following three areas: (1) theoretical and applied aspects of the neuropsychology of aging and dementia risk, (2) structural imaging methodologies with an emphasis on diffusion tensor imaging (DTI), and (3) the integration of these two areas with an experimental learning paradigm, eyeblink classical conditioning (EBCC), to better understand the nature of brain structure-function relationships. The focus of this proposal and training plan lies in the strength of each approach and the synergy gained through their integration. This will be accomplished with advanced training, mentorship, didactics, and formal instruction in these content areas in an enriched training environment with a team of skilled and dedicated mentors, consultants, and advisors. The training environments will provide excellent institutional support and tremendous resources to the candidate. The mentors, advisors, and consultants include experts in each facet of proposed training and research areas and will ensure exemplary guidance. The proposed research project will use the eyeblink classical conditioning paradigm and neuropsychological assessment to link behavioral changes to underlying neuropathological changes in a population of aging individuals at risk for Alzheimer's disease (AD) and cerebrovascular disease (CVD). AD and CVD adversely impact the brain in different regions and are characterized by distinct neuroanatomical and neuropsychological underpinnings. These brain regions have been implicated in the circuit underlying the acquisition and expression of EBCC associative responses. This proposal has three specific aims: (1) to determine if performance in a complex EBCC learning task can dissociate individuals at risk AD from CVD, (2) to determine if these learning impairments will be associated with dissociable morphometric changes, and (3) to examine the rates of decline longitudinally.

描述（由申请人提供）：本申请以患者为导向的研究职业发展奖（K23）旨在为候选人提供认知神经科学互补和综合领域的特定技能和指导，为独立研究生涯做好准备。该提案描述了一项全面的五年培训计划，重点是扩展候选人的技能并发展以下三个领域的专业知识：（1）衰老和痴呆风险神经心理学的理论和应用方面，（2）结构成像方法，重点是扩散张量成像（DTI），以及（3）将这两个领域与实验学习范式（眨眼经典条件反射）相结合（EBCC），更好地理解大脑结构与功能关系的本质。该提案和培训计划的重点在于每种方法的优势以及通过整合所获得的协同作用。这将通过在丰富的培训环境中通过这些内容领域的高级培训、指导、教学和正式指导来实现，团队由熟练且专注的导师、顾问和顾问组成。培训环境将为候选人提供良好的机构支持和巨大的资源。导师、顾问和顾问包括拟议培训和研究领域各个方面的专家，并将确保提供模范指导。拟议的研究项目将使用眨眼经典调节范式和神经心理学评估，将存在阿尔茨海默病（AD）和脑血管疾病（CVD）风险的老年人群的行为变化与潜在的神经病理学变化联系起来。 AD 和 CVD 对不同区域的大脑产生不利影响，并且具有不同的神经解剖学和神经心理学基础。这些大脑区域与 EBCC 联想反应的获取和表达的回路有关。该提案有三个具体目标：(1) 确定复杂 EBCC 学习任务的表现是否可以将 AD 风险个体与 CVD 分离，(2) 确定这些学习障碍是否与可分离的形态变化相关，(3) 纵向检查下降率。