USC Tobacco Center of Regulatory Science

南加州大学烟草监管科学中心

• 批准号: 10664805
• 负责人: CARYN LERMAN
• 金额: $ 400万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10664805
• 关键词: Achievement; Address; Adolescent and Young Adult; Adult; Age; Area; Automobile Driving; Behavior; Characteristics; Cigarette Smoker; Classification; Collaborations; Communication; Communities; Creativeness; Data; Data Analyses; Data Analytics; Databases; Development; Electronic cigarette; Epidemiology; Esthesia; Ethnic Origin; Fostering; Future; Gender Identity; Harm Reduction; Immersion; Infrastructure; Leadership; Longitudinal cohort study; Marketing; Measures; Mental Health; Mentors; Methods; Modernization; Monitor; Names; Nicotine; Oral; Pattern; Peer Review; Persons; Pilot Projects; Policies; Population; Postdoctoral Fellow; Predisposition; Productivity; Publishing; Race; Reduce health disparities; Regulation; Research; Research Personnel; Risk; Sales; Sampling; Science; Scientist; Sexual and Gender Minorities; Speed; Stimulus; Surveys; Testing; TikTok; Time; Tobacco; Tobacco use; Training; Youth; abuse liability; addiction; career; cohort; computerized data processing; crowdsourcing; data management; design; electronic cigarette user; experimental study; health disparity; innovation; next generation; nicotine use; novel; outreach; post-market; prevent; programs; progression risk; recruit; response; social media; synergism; tobacco advertising; tobacco products; tobacco regulatory science; trend; uptake; virtual visit; young adult

SUMMARY/ABSTRACT: USC TCORS OVERALL In response to new FDA landmark policies targeting tobacco products with flavors and other youth-attracting features, the non-combustible market is evolving in ways that could perpetuate adolescent and young adult (AYA) use. Shifts to the non-combustible tobacco market include the emergence of modern oral nicotine products (ONPs; flavored nicotine pouches, non-therapeutic gums, lozenges, gummies) with rapidly increasing sales, e-cigarettes and ONPs with novel flavors and higher nicotine concentrations (e.g., concept flavors with ambiguous flavor names that are difficult for the FDA to classify but offer fruity sensations and e-cigarettes with >6% nicotine), and novel marketing platforms (TikTok and other social media that highly engage AYAs). USC TCORS responds to these challenges with a theme of “Informing regulation of the evolving market of non- combustible products to protect young people.” The overall Center specific aims are: Aim 1) Conduct four interrelated projects that will: (a) determine how modern ONPs and e-cigarettes impact AYA tobacco product use uptake, escalation, abuse liability, and poly-use patterns across populations; (b) identify product characteristics and marketing approaches that amplify these impacts; Aim 2) Augment our Center’s infrastructure with three cores that will optimize the productivity and impact of our regulatory science (Administrative Core, Measures and Materials Core, Data Processing and Analysis Core); and Aim 3) Develop the next generation of tobacco regulatory scientists via developing the careers of doctoral and post-doctoral trainees, and investigators transitioning to tobacco regulatory science (TRS). Collectively, USC TCORS will provide key evidence determining whether availability of certain non-combustible product classes (e.g., new ONPs), types (e.g., products that can be used discreetly), characteristics (e.g., e-cigarettes and ONPs in concept flavors), and marketing strategies (e.g., social media influencers) increase AYA’s risk of initiating and progressing along the tobacco use trajectory, including in key AYA subpopulations (e.g., sexual/gender minorities). This research will directly inform FDA’s responses to numerous e-cigarette, ONP, and other illegally marketed non-combustible products. It will provide rigorous actionable evidence to guide FDA decisions on pending marketing applications from tobacco product companies. The data will also inform FDA policies regarding which illegally-marketed products should be targeted as enforcement priorities. These achievements will build upon our successful USC TCORS Centers that, since 2013, has published 237 peer reviewed articles (166 of these published since 2018). Further, we have a substantial track record of: (a) providing foundational evidence informing FDA’s development of new policies; and (b) rapidly adapting our research to inform FDA revision of previous policies to keep pace with the evolving market; this is evidenced by 31 citations of TCORS research in FDA policy documents. FDA Scientific Areas: Behavior, Addiction and Marketing

摘要/摘要：USC TCORS总体 回应FDA针对具有风味和其他吸引年轻人的烟草产品的新的里程碑式的政策 不可燃物市场正在以一种可能使青少年和年轻人永久化的方式发展 (阿雅)使用。向不可燃烟草市场的转移包括现代口服尼古丁的出现 产品(ONPs；加味尼古丁胶囊、非治疗性口香糖、含片、口香糖)迅速增加 销售、电子烟和具有新口味和更高尼古丁浓度的ONPs(例如，具有 模糊的味道名称，FDA很难分类，但提供水果味和电子烟 以及新颖的营销平台(TikTok和其他高度吸引AYA的社交媒体)。南加州大学 为应对这些挑战，TCORS的主题是：向监管部门通报不断变化的非 保护年轻人的可燃产品。中心的总体具体目标是：目标1)开展四项活动 相互关联的项目，将：(A)确定现代ONPs和电子烟对Aya烟草产品的影响 跨人群的使用情况、升级、滥用倾向和多用途模式；(B)确定产品 放大这些影响的特点和营销方法；目标2)增强我们中心的基础设施 三个核心将优化我们的监管科学的工作效率和影响(管理核心、 测量和材料核心、数据处理和分析核心)；以及目标3)开发下一代 烟草监管科学家通过发展博士后和博士后实习生和调查人员的职业生涯 向烟草监管科学(TRS)过渡。总体而言，南加州大学TCORS将提供关键证据 确定某些不可燃产品类别(例如，新的ONP)、类型(例如， 可谨慎使用的产品)、特性(例如，电子烟和概念口味中的ONPs)；以及 营销策略(例如，社交媒体影响者)增加了Aya启动和发展的风险 烟草使用轨迹，包括关键的Aya亚群(例如，性/性别少数群体)。这项研究将 直接通知FDA对大量电子烟、ONP和其他非法销售的不可燃物品的回应 产品。它将提供严格的可操作的证据，以指导FDA对未决的营销申请做出决定 来自烟草产品公司。这些数据还将告知FDA关于哪些非法销售的政策 应将产品作为执法重点。这些成就将建立在我们成功的南加州大学的基础上 TCORS中心，自2013年以来，已经发表了237篇同行评议文章(其中166篇是2018年以来发表的)。 此外，我们在以下方面有很好的记录：(A)为FDA的发展提供基本证据 新政策；以及(B)迅速调整我们的研究，以便向FDA通报先前政策的修订，以跟上步伐 随着市场的发展，FDA政策文件中对TCORS研究的31次引用证明了这一点。 FDA科学领域：行为、成瘾和营销

项目成果

An Assessment of Vape Shop Products in California before and after Implementation of FDA and State Regulations.

• DOI: 10.3390/ijerph192315827
• 发表时间: 2022-11-28
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Galstyan, Ellen;Galimov, Artur;Meza, Leah;Huh, Jimi;Berg, Carla J.;Unger, Jennifer B.;Baezconde-Garbanati, Lourdes;Sussman, Steve
• 通讯作者: Sussman, Steve

Examining tobacco-related social media research in government policy documents: systematic review.

• DOI: 10.1093/ntr/ntad172
• 发表时间: 2023-09
• 期刊: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
• 作者: Trista A. Beard;S. Donaldson;Jennifer B. Unger;Jon-Patrick Allem

Hypothetical flavour ban and intention to vape among vape shop customers: the role of flavour preference and e-cigarette dependence.

• DOI: 10.1136/tobaccocontrol-2020-056321
• 发表时间: 2023-01
• 期刊: Tobacco control
• 影响因子: 5.2
• 作者: Huh J;Yu S;Galimov A;Meza LR;Galstyan E;Medel D;Unger JB;Baezconde-Garbanati L;Sussman S
• 通讯作者: Sussman S

Prevalence of disposable pod use and consumer preference for e-cigarette product characteristics among vape shop customers in Southern California: a cross-sectional study.

• DOI: 10.1136/bmjopen-2021-049604
• 发表时间: 2021-10-05
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Galimov A;Leventhal A;Meza L;Unger JB;Huh J;Baezconde-Garbanati L;Sussman SY
• 通讯作者: Sussman SY

Trajectories of Nicotine Use Leading to Dual and Cyclical Tobacco Product Use in Young Adults.

尼古丁使用轨迹导致年轻人双重和周期性使用烟草产品。

• DOI: 10.1093/ntr/ntab249
• 发表时间: 2022
• 期刊: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
• 作者: Kechter,Afton;Simpson,KelseyA;Ceasar,RachelCarmen;Schiff,SaraJ;Yamaguchi,Naosuke;Bluthenthal,RickyN;Smiley,SabrinaL;Barrington-Trimis,JessicaL
• 通讯作者: Barrington-Trimis,JessicaL