Center for Interdisciplinary Research on Nicotine Addiction (CIRNA)

尼古丁成瘾跨学科研究中心 (CIRNA)

• 批准号: 8530980
• 负责人: CARYN LERMAN
• 金额: $ 153.94万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8530980
• 关键词: Abstinence; Address; Behavioral; Behavioral Mechanisms; Biological; Biostatistics Core; Brain; Brain region; Clinical Research; Disease; Electrophysiology (science); Emotional; Goals; Human; Interdisciplinary Study; Knowledge; Molecular; Mus; Neurobehavioral Manifestations; Neurobiology; Nicotine; Nicotine Dependence; Pharmaceutical Preparations; Pharmacology; Pilot Projects; Postdoctoral Fellow; Process; Relapse; Research; Research Personnel; Resource Sharing; Sensory Process; Smoking; Symptoms; Tobacco; Tobacco Dependence; Transdisciplinary Tobacco Research Center; United States National Institutes of Health; Work; base; career development; data management; data sharing; improved; innovation; interdisciplinary approach; mouse model; neuroimaging; novel; novel strategies; pre-clinical; relating to nervous system; response; screening; smoking relapse; tobacco prevention

Abstinence from smoking produces aversive symptoms that prompt relapse, often within the first week following a quit attempt. Clarifying the neurobiological and behavioral underpinnings of these early abstinence symptoms is, therefore, critical to develop more efficacious treatments. The proposed Center for Interdisciplinary Research on Nicotine Addiction (CIRNA) extends nine years of research conducted in the Transdisciplinary Tobacco Use Research Center (TTURC) at UPENN. Spanning from preclinical to clinical studies, CIRNA includes a highly interactive set of projects and cores that seek to: (1) discover the cellular, molecular, neural, and behavioral basis of early nicotine abstinence effects that contribute to relapse; (2) identify brain and behavioral mechanisms through which efficacious therapies modulate these processes; and (3) validate novel medication screening approaches. Project 1 uses neurobiology and pharmacology to elucidate the molecular and behavioral basis of emotional and cognitive symptoms of nicotine abstinence and re-exposure in a mouse model. Project 2 uses electrophysiology and pharmacology to explore the effects of nicotine abstinence and re-exposure on sensory processing in key brain regions in mice. Project 3 uses human neuroimaging to examine the neural substrates of early abstinence symptoms and medication response. Project 4 extends this work by validating novel approaches to improve the sensitivity of early human medication screening paradigms for nicotine dependence. Shared resources, including an Administrative Core, a Data Management and Biostatistics Core, and a Biospecimen Core provide value-added, as well as support for a comprehensive data sharing plan. A Career Development Core promotes involvement of post-doctoral fellows and junior investigators in these projects, and supports pilot projects to facilitate career development. Thus, the CIRNA addresses the clinically important problem of nicotine dependence using innovative multidisciplinary approaches, with the ultimate goal of developing more efficacious medications for tobacco dependence and prevention of tobacco-related disease. The CIRNA is proposed to replace the TTURC, since this NIH initiative is ending.

戒烟会产生令人厌恶的症状，促使复发，通常在戒烟尝试后的第一周内。因此，澄清这些早期禁欲症状的神经生物学和行为基础对于开发更有效的治疗方法至关重要。拟议中的尼古丁成瘾跨学科研究中心（CIRNA）延长了在宾夕法尼亚大学跨学科烟草使用研究中心（TTURC）进行的九年研究。从临床前到临床研究，CIRNA包括一系列高度互动的项目和核心，旨在：（1）发现导致复发的早期尼古丁戒断效应的细胞，分子，神经和行为基础;（2）确定有效治疗调节这些过程的大脑和行为机制;（3）验证新型药物筛选方法。项目1使用神经生物学和药理学来阐明小鼠模型中尼古丁戒断和再暴露的情绪和认知症状的分子和行为基础。项目2使用电生理学和药理学来探索尼古丁戒断和重新暴露对小鼠关键脑区感觉处理的影响。项目3使用人类神经影像学检查早期戒断症状和药物反应的神经基质。项目4通过验证新方法来扩展这项工作，以提高尼古丁依赖早期人类药物筛选范式的灵敏度。共享资源，包括行政核心，数据管理和生物统计核心，以及生物标本核心提供增值，以及支持全面的数据共享计划。职业发展核心促进博士后研究员和初级研究人员参与这些项目，并支持试点项目，以促进职业发展。因此，CIRNA使用创新的多学科方法解决尼古丁依赖的临床重要问题，最终目标是开发更有效的烟草依赖药物和预防烟草相关疾病。CIRNA被提议取代TTURC，因为NIH的这一倡议即将结束。

项目成果

Divergent functional effects of sazetidine-a and varenicline during nicotine withdrawal.

尼古丁戒断过程中萨泽替丁-a 和伐尼克兰的不同功能作用。

• DOI: 10.1038/npp.2013.105
• 发表时间: 2013
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• 作者: Turner,JillR;Wilkinson,DerekS;Poole,RachelLf;Gould,ThomasJ;Carlson,GregoryC;Blendy,JulieA
• 通讯作者: Blendy,JulieA

Evaluating the Effects of Varenicline on Craving, Withdrawal, and Affect in a Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Varenicline for Smokeless Tobacco Dependence in India.

在印度进行的瓦伦尼克兰治疗无烟烟草依赖的随机、双盲、安慰剂对照临床试验中评估瓦伦尼克兰对渴望、戒断和影响的影响。

• DOI: 10.1080/02791072.2015.1075092
• 发表时间: 2015
• 期刊: Journal of psychoactive drugs
• 影响因子: 2.8
• 作者: Jhanjee,Sonali;Jain,Raka;Jain,Veena;Gupta,Tina;Mittal,Swati;Goelz,Patricia;Schnoll,RobertA
• 通讯作者: Schnoll,RobertA

Time dependency of craving and response inhibition during nicotine abstinence.

• DOI: 10.3109/16066359.2014.953940
• 发表时间: 2015
• 期刊: Addiction research & theory
• 影响因子: 2.9
• 作者: Tsaur S;Strasser AA;Souprountchouk V;Evans GC;Ashare RL
• 通讯作者: Ashare RL

Sensitivity and specificity of a procedure for early human screening of novel smoking cessation medications.

新型戒烟药物早期人体筛查程序的敏感性和特异性。

• DOI: 10.1111/add.12273
• 发表时间: 2013
• 期刊: Addiction (Abingdon, England)
• 作者: Perkins,KennethA;Lerman,Caryn;Karelitz,JoshuaL;Jao,NancyC;Chengappa,KNRoy;Sparks,GarrettM
• 通讯作者: Sparks,GarrettM

Extrasynaptic targeting of NMDA receptors following D1 dopamine receptor activation and cocaine self-administration.

D1多巴胺受体激活和可卡因自我给药后，NMDA受体的外突触靶向。

• DOI: 10.1523/jneurosci.5730-12.2013
• 发表时间: 2013-05-29
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Ortinski PI;Turner JR;Pierce RC
• 通讯作者: Pierce RC