Nest#1-High density Interconnect with Variable Electronics (HIVE)

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• 批准号: 10549468
• 负责人: Cynthia Anne Chestek
• 金额: $ 94.12万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-10 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10549468
• 关键词: 3D Print; Academia; Adopted; Aerosols; Biological Markers; Brain; Cardiac; Catalogs; Cities; Clinical; Communication; Communities; Consumption; Data; Devices; Electrodes; Electronics; Ensure; FPS-FES Oncogene; Failure; Feedback; Funding; Goals; Human; Implant; Industry; Investments; Lasers; Lead; Libraries; Location; Mechanics; Medical; Medical Device; Modification; Monkeys; Nerve; Ocular Prosthesis; Operative Surgical Procedures; Persons; Pilot Projects; Publishing; Research; Research Personnel; Safety; Sampling; Spinal; Spinal cord injury; System; Technology; Test Result; Testing; Time; Titanium; Utah; Validation; Vendor; Vision; Welding; Work; base; density; design; experimental study; first-in-human; implantable device; innovation; microchip; nano; neural prosthesis; novel; open source; operation; powered prosthesis; prevent; prosthetic hand; prototype; safety testing; seal; verification and validation; wireless communication

Project Summary/Abstract The Networked Neural Prosthesis (NNP), which forms the basis of the COSMIIC library, is already in use in people with spinal cord injuries and provides a range of recording and stimulation capabilities. Implanting multiple modules at the same time enables 10+ channel operation. However, many applications simply require higher channel count modules for when there is a multichannel electrode array in one location (e.g. Utah arrays, ECoG style cardiac electrodes, multicontact C-FINE nerve cuffs, spinal paddle electrodes, etc.). The goal of this NEST, entitled High-density Interconnects with Variable Electronics or “HIVE”, is to design a high channel count general purpose device for both recording and stimulation. Our team has the unique expertise to complete this task. The existing NNP provides a great deal of reusable circuitry, and the Chestek Lab has already designed a 96-channel NNP recording module that is in use in weekly monkey experiments. Medical device packaging and validation testing experts Drs. Doug Shire and Janet Gbur, meanwhile, have developed world-leading high-density hermetic packaging for visual prosthetics and Nano-Jet aerosol-3D printed connector/lead assemblies. We will achieve our goal in the following three specific aims: Aim 1) Create and validate an electronics module for 64 channel recording. We will design and validate modular circuitry for 64-channel recording, based on our previous published NNP module (Bullard et al. 2019) using microchips from Intan Technologies. Aim 2) Create and validate a general purpose 64-channel package. We will create a general purpose 64-channel package compatible with the NNP network, only slightly larger than existing modules. We will achieve this by using multiple commercial off the shelf 8 channel feedthroughs within the same welded titanium package. This package will be usable with hardwired connections, and we will also develop a novel connector system for up to 64 channels. Aim 3) Create and validate a module for 32 channel stimulation and recording. There are many applications that would benefit from higher channel count stimulation as well as simultaneous recording and stimulation on the same electrodes. Therefore, we will design and validate modular circuitry for a 32-channel bidirectional module. After we are done, there will be a catalog of high channel count implantable device components that can be adopted in whole or in part by academic users or even startup medical companies looking for an initial foothold for a new application. These designs will be fully documented, including the supply chain, with the verification and validation tests results and design files provided publicly online.

项目摘要/摘要 网络神经假体(NNP)是COSMIIC库的基础，已经在 有脊髓损伤的人，并提供一系列记录和刺激功能。植入 多个模块同时支持10+通道操作。但是，许多应用程序只需要 更高的通道数模块，用于在一个位置(例如犹他州)有多通道电极阵列时 阵列、ECoG型心脏电极、多触点C-精细神经袖带、脊桨电极等)。这个 这个名为高密度互连与可变电子设备或“蜂巢”的Nest的目标是设计一种高密度 用于记录和刺激的通道计数通用装置。我们的团队拥有独特的专业知识来 完成此任务。现有的NNP提供了大量可重复使用的电路，而Chestek实验室 已经设计了一个96通道的NNP记录模块，用于每周的猴子实验。医疗 与此同时，设备封装和验证测试专家Doug Shire博士和Janet Gbur博士已经开发出 世界领先的视觉假体和Nano-Jet气雾剂高密度密封包装-3D打印 连接器/引线组件。我们将在以下三个具体目标中实现我们的目标：目标1)创造和 验证用于频道录制的电子模块。我们将设计和验证模块化电路 -频道录制，基于我们之前发布的NNP模块(Bullard等人2019)使用微芯片 来自Intan技术公司。目的2)创建并验证通用频道包。我们会 创建与NNP网络兼容的通用频道包，仅略大于 现有模块。我们将通过在8个频道内使用多个现成的商业广告来实现这一点 同样的焊接钛包装。这个包将可用于硬连线连接，我们还将 开发一种最高可达通道的新型连接器系统。目标3)创建并验证适用于32人的模块 通道刺激和记录。有许多应用程序将受益于更高的渠道 计数刺激以及在同一电极上同时记录和刺激。因此，我们将 设计并验证32通道双向模块的模块化电路。在我们完成之后，将会有一个 可全部或部分采用的高通道数植入式设备部件目录 为新应用寻找初始立足点的学术用户，甚至是初创医疗公司。这些 将对设计进行全面记录，包括供应链，并提供验证和确认测试结果 以及在网上公开提供的设计文件。