Nest#1-High density Interconnect with Variable Electronics (HIVE)

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• 批准号: 10549468
• 负责人: Cynthia Anne Chestek
• 金额: $ 94.12万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-10 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10549468
• 关键词: 3D Print; Academia; Adopted; Aerosols; Biological Markers; Brain; Cardiac; Catalogs; Cities; Clinical; Communication; Communities; Consumption; Data; Devices; Electrodes; Electronics; Ensure; FPS-FES Oncogene; Failure; Feedback; Funding; Goals; Human; Implant; Industry; Investments; Lasers; Lead; Libraries; Location; Mechanics; Medical; Medical Device; Modification; Monkeys; Nerve; Ocular Prosthesis; Operative Surgical Procedures; Persons; Pilot Projects; Publishing; Research; Research Personnel; Safety; Sampling; Spinal; Spinal cord injury; System; Technology; Test Result; Testing; Time; Titanium; Utah; Validation; Vendor; Vision; Welding; Work; base; density; design; experimental study; first-in-human; implantable device; innovation; microchip; nano; neural prosthesis; novel; open source; operation; powered prosthesis; prevent; prosthetic hand; prototype; safety testing; seal; verification and validation; wireless communication

Project Summary/Abstract The Networked Neural Prosthesis (NNP), which forms the basis of the COSMIIC library, is already in use in people with spinal cord injuries and provides a range of recording and stimulation capabilities. Implanting multiple modules at the same time enables 10+ channel operation. However, many applications simply require higher channel count modules for when there is a multichannel electrode array in one location (e.g. Utah arrays, ECoG style cardiac electrodes, multicontact C-FINE nerve cuffs, spinal paddle electrodes, etc.). The goal of this NEST, entitled High-density Interconnects with Variable Electronics or “HIVE”, is to design a high channel count general purpose device for both recording and stimulation. Our team has the unique expertise to complete this task. The existing NNP provides a great deal of reusable circuitry, and the Chestek Lab has already designed a 96-channel NNP recording module that is in use in weekly monkey experiments. Medical device packaging and validation testing experts Drs. Doug Shire and Janet Gbur, meanwhile, have developed world-leading high-density hermetic packaging for visual prosthetics and Nano-Jet aerosol-3D printed connector/lead assemblies. We will achieve our goal in the following three specific aims: Aim 1) Create and validate an electronics module for 64 channel recording. We will design and validate modular circuitry for 64-channel recording, based on our previous published NNP module (Bullard et al. 2019) using microchips from Intan Technologies. Aim 2) Create and validate a general purpose 64-channel package. We will create a general purpose 64-channel package compatible with the NNP network, only slightly larger than existing modules. We will achieve this by using multiple commercial off the shelf 8 channel feedthroughs within the same welded titanium package. This package will be usable with hardwired connections, and we will also develop a novel connector system for up to 64 channels. Aim 3) Create and validate a module for 32 channel stimulation and recording. There are many applications that would benefit from higher channel count stimulation as well as simultaneous recording and stimulation on the same electrodes. Therefore, we will design and validate modular circuitry for a 32-channel bidirectional module. After we are done, there will be a catalog of high channel count implantable device components that can be adopted in whole or in part by academic users or even startup medical companies looking for an initial foothold for a new application. These designs will be fully documented, including the supply chain, with the verification and validation tests results and design files provided publicly online.

项目总结/摘要 构成COSMIIC库基础的网络神经假体（NNP）已经在 它为脊髓损伤患者提供了一系列的记录和刺激功能。植入 多个模块同时支持10+通道操作。然而，许多应用程序只需要 当在一个位置（例如，犹他州）存在多通道电极阵列时，通道数更高的模块 阵列、ECoG型心脏电极、多触点C-FINE神经袖带、脊髓桨状电极等）。的 这个名为“可变电子高密度互连”或“HIVE”的NEST的目标是设计一个高密度互连。 用于记录和刺激的通道计数通用设备。我们的团队拥有独特的专业知识， 完成这项任务。现有的NNP提供了大量可重复使用的电路，Chestek实验室已经 已经设计了一个96通道NNP记录模块，用于每周的猴子实验。医疗 与此同时，设备包装和验证测试专家Doug Shire博士和Janet Gbur博士开发了 世界领先的高密度密封包装，用于视觉修复和Nano-Jet气溶胶-3D打印 连接器/导线组件。我们将通过以下三个具体目标来实现我们的目标：目标1）创造和 验证64通道记录的电子模块。我们将设计和验证模块化电路， 64-通道记录，基于我们之前发布的使用微芯片的NNP模块（Bullard等人，2019） 来自Intan Technologies。目标2）创建并验证通用64通道包。我们将 创建与NNP网络兼容的通用64通道封装，仅略大于 现有模块。我们将通过使用多个商用现成的8通道馈源来实现这一点， 同样的焊接钛合金包装该软件包将可用于硬连线连接，我们还将 开发一种新颖的连接器系统，可用于多达64个通道。目标3）创建并验证32个模块 通道刺激和记录。有许多应用程序将受益于更高的通道 计数刺激以及在相同电极上同时记录和刺激。所以我们会 设计并验证32通道双向模块的模块化电路。我们完成后，会有一个 可全部或部分采用的高通道数植入式器械组件目录 学术用户，甚至是正在为新应用程序寻找初始立足点的初创医疗公司。这些 设计将被完整记录，包括供应链，以及验证和确认测试结果 以及在线公开提供的设计文件。