Nest#1-High density Interconnect with Variable Electronics (HIVE)
巢
基本信息
- 批准号:10549468
- 负责人:
- 金额:$ 94.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-10 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:3D PrintAcademiaAdoptedAerosolsBiological MarkersBrainCardiacCatalogsCitiesClinicalCommunicationCommunitiesConsumptionDataDevicesElectrodesElectronicsEnsureFPS-FES OncogeneFailureFeedbackFundingGoalsHumanImplantIndustryInvestmentsLasersLeadLibrariesLocationMechanicsMedicalMedical DeviceModificationMonkeysNerveOcular ProsthesisOperative Surgical ProceduresPersonsPilot ProjectsPublishingResearchResearch PersonnelSafetySamplingSpinalSpinal cord injurySystemTechnologyTest ResultTestingTimeTitaniumUtahValidationVendorVisionWeldingWorkbasedensitydesignexperimental studyfirst-in-humanimplantable deviceinnovationmicrochipnanoneural prosthesisnovelopen sourceoperationpowered prosthesispreventprosthetic handprototypesafety testingsealverification and validationwireless communication
项目摘要
Project Summary/Abstract
The Networked Neural Prosthesis (NNP), which forms the basis of the COSMIIC library, is already in use in
people with spinal cord injuries and provides a range of recording and stimulation capabilities. Implanting
multiple modules at the same time enables 10+ channel operation. However, many applications simply require
higher channel count modules for when there is a multichannel electrode array in one location (e.g. Utah
arrays, ECoG style cardiac electrodes, multicontact C-FINE nerve cuffs, spinal paddle electrodes, etc.). The
goal of this NEST, entitled High-density Interconnects with Variable Electronics or “HIVE”, is to design a high
channel count general purpose device for both recording and stimulation. Our team has the unique expertise to
complete this task. The existing NNP provides a great deal of reusable circuitry, and the Chestek Lab has
already designed a 96-channel NNP recording module that is in use in weekly monkey experiments. Medical
device packaging and validation testing experts Drs. Doug Shire and Janet Gbur, meanwhile, have developed
world-leading high-density hermetic packaging for visual prosthetics and Nano-Jet aerosol-3D printed
connector/lead assemblies. We will achieve our goal in the following three specific aims: Aim 1) Create and
validate an electronics module for 64 channel recording. We will design and validate modular circuitry for
64-channel recording, based on our previous published NNP module (Bullard et al. 2019) using microchips
from Intan Technologies. Aim 2) Create and validate a general purpose 64-channel package. We will
create a general purpose 64-channel package compatible with the NNP network, only slightly larger than
existing modules. We will achieve this by using multiple commercial off the shelf 8 channel feedthroughs within
the same welded titanium package. This package will be usable with hardwired connections, and we will also
develop a novel connector system for up to 64 channels. Aim 3) Create and validate a module for 32
channel stimulation and recording. There are many applications that would benefit from higher channel
count stimulation as well as simultaneous recording and stimulation on the same electrodes. Therefore, we will
design and validate modular circuitry for a 32-channel bidirectional module. After we are done, there will be a
catalog of high channel count implantable device components that can be adopted in whole or in part by
academic users or even startup medical companies looking for an initial foothold for a new application. These
designs will be fully documented, including the supply chain, with the verification and validation tests results
and design files provided publicly online.
项目总结/摘要
构成COSMIIC库基础的网络神经假体(NNP)已经在
它为脊髓损伤患者提供了一系列的记录和刺激功能。植入
多个模块同时支持10+通道操作。然而,许多应用程序只需要
当在一个位置(例如,犹他州)存在多通道电极阵列时,通道数更高的模块
阵列、ECoG型心脏电极、多触点C-FINE神经袖带、脊髓桨状电极等)。的
这个名为“可变电子高密度互连”或“HIVE”的NEST的目标是设计一个高密度互连。
用于记录和刺激的通道计数通用设备。我们的团队拥有独特的专业知识,
完成这项任务。现有的NNP提供了大量可重复使用的电路,Chestek实验室已经
已经设计了一个96通道的NNP记录模块,用于每周一次的猴子实验。医疗
与此同时,设备包装和验证测试专家Doug Shire博士和Janet Gbur博士开发了
世界领先的高密度密封包装,用于视觉修复和Nano-Jet气溶胶-3D打印
连接器/导线组件。我们将通过以下三个具体目标来实现我们的目标:目标1)创造和
验证64通道记录的电子模块。我们将设计和验证模块化电路,
64-通道记录,基于我们之前发布的使用微芯片的NNP模块(Bullard等人,2019)
来自Intan Technologies。目标2)创建并验证通用64通道包。我们将
创建与NNP网络兼容的通用64通道封装,仅略大于
现有模块。我们将通过使用多个商用现成的8通道馈源来实现这一点,
同样的焊接钛合金包装该软件包将可用于硬连线连接,我们还将
开发一种新颖的连接器系统,可用于多达64个通道。目标3)创建并验证32个模块
通道刺激和记录。有许多应用程序将受益于更高的通道
计数刺激以及在相同电极上同时记录和刺激。所以我们会
设计并验证32通道双向模块的模块化电路。我们完成后,会有一个
可全部或部分采用的高通道数植入式器械组件目录
学术用户,甚至是正在为新应用程序寻找初始立足点的初创医疗公司。这些
设计将被完整记录,包括供应链,以及验证和确认测试结果
以及在线公开提供的设计文件。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Cynthia Anne Chestek其他文献
Cynthia Anne Chestek的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Cynthia Anne Chestek', 18)}}的其他基金
Nest#1-High density Interconnect with Variable Electronics (HIVE)
巢
- 批准号:
10701813 - 财政年份:2022
- 资助金额:
$ 94.12万 - 项目类别:
Cleveland Open Source Modular Implant Innovators Community (COSMIIC)
克利夫兰开源模块化植入物创新者社区 (COSMIIC)
- 批准号:
10701809 - 财政年份:2022
- 资助金额:
$ 94.12万 - 项目类别:
Cleveland Open Source Modular Implant Innovators Community (COSMIIC)
克利夫兰开源模块化植入物创新者社区 (COSMIIC)
- 批准号:
10549466 - 财政年份:2022
- 资助金额:
$ 94.12万 - 项目类别:
Regenerative Peripheral Nerve Interface for Restoring Individual Finger Movement in People with Upper Limb Amputations
用于恢复上肢截肢患者个体手指运动的再生周围神经接口
- 批准号:
9596051 - 财政年份:2018
- 资助金额:
$ 94.12万 - 项目类别:
Regenerative Peripheral Nerve Interface for Restoring Individual Finger Movement in People with Upper Limb Amputations
用于恢复上肢截肢患者个体手指运动的再生周围神经接口
- 批准号:
10451527 - 财政年份:2018
- 资助金额:
$ 94.12万 - 项目类别:
Regenerative Peripheral Nerve Interface for Restoring Individual Finger Movement in People with Upper Limb Amputations
用于恢复上肢截肢患者个体手指运动的再生周围神经接口
- 批准号:
10213854 - 财政年份:2018
- 资助金额:
$ 94.12万 - 项目类别:
相似海外基金
Conference: Rethinking how language background is described in academia and beyond
会议:重新思考学术界及其他领域如何描述语言背景
- 批准号:
2335912 - 财政年份:2024
- 资助金额:
$ 94.12万 - 项目类别:
Standard Grant
ADVANCE Catalyst: Virtual Observatory of Culture for Equity in Academia at the University of Puerto Rico Rio Piedras (VoCEA)
ADVANCE Catalyst:波多黎各 Rio Piedras 大学学术界平等文化虚拟观察站 (VoCEA)
- 批准号:
2214418 - 财政年份:2023
- 资助金额:
$ 94.12万 - 项目类别:
Standard Grant
Comprehensive development strategy of modality-specific "intellectual property" and "cultivation" with an eye on "pharmaceutical affairs" in academia drug discovery
学术界新药研发着眼“药事”的模式“知识产权”与“培育”综合发展策略
- 批准号:
23K02551 - 财政年份:2023
- 资助金额:
$ 94.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accelerating Research Advancement for Investigators Underrepresented in Academia
加速学术界代表性不足的研究人员的研究进展
- 批准号:
10746315 - 财政年份:2023
- 资助金额:
$ 94.12万 - 项目类别:
Planning: HBCU-UP: Strengthening Data Science Research Capacity and Education Programs through Academia-Industry Partnership
规划:HBCU-UP:通过学术界与工业界合作加强数据科学研究能力和教育计划
- 批准号:
2332161 - 财政年份:2023
- 资助金额:
$ 94.12万 - 项目类别:
Standard Grant
From Academia to Business: Development of Novel Therapeutics Against HPV-Associated Cancer
从学术界到商界:针对 HPV 相关癌症的新型疗法的开发
- 批准号:
10813323 - 财政年份:2023
- 资助金额:
$ 94.12万 - 项目类别:
Academics4Rail: Building a Community of Railway Scientific Researchers and Academia for ERJU and Enabling a Network of PhDs (Academia Teaming with Industry)
Academys4Rail:为二院建立铁路科研人员和学术界社区并启用博士网络(学术界与工业界合作)
- 批准号:
10102850 - 财政年份:2023
- 资助金额:
$ 94.12万 - 项目类别:
EU-Funded
Academics4Rail: Building a community of railway scientific researchers and academia for ERJU and enabling a network of PhDs (academia teaming with industry)
Academys4Rail:为ERJU建立铁路科研人员和学术界社区并建立博士网络(学术界与工业界合作)
- 批准号:
10087488 - 财政年份:2023
- 资助金额:
$ 94.12万 - 项目类别:
EU-Funded
Exploring the overall picture of industry-academia-government collaboration: A spectrum of knowledge transfer through formal and informal channels
探索产学官合作的整体图景:通过正式和非正式渠道进行的一系列知识转移
- 批准号:
22K01692 - 财政年份:2022
- 资助金额:
$ 94.12万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Fostering Ethical Neurotechnology Academia-Industry Partnerships: A Stakeholder Engagement and Toolkit Development Project
促进道德神经技术学术界与工业界的伙伴关系:利益相关者参与和工具包开发项目
- 批准号:
10655632 - 财政年份:2022
- 资助金额:
$ 94.12万 - 项目类别: