Wearable modular high-density diffuse optical tomography

可穿戴式模块化高密度漫射光学断层扫描

• 批准号: 10547630
• 负责人: Jason Wayne Trobaugh
• 金额: $ 43.27万
• 依托单位: ESPERIMAGE LLC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10547630
• 关键词: Adult; Affect; BRAIN initiative; Behavioral; Behavioral Symptoms; Brain; Brain Diseases; Brain Mapping; Brain imaging; Child; Child Development; Childhood; Cognitive; Comb animal structure; Communication; Coupling; Detection; Development; Devices; Disease; Early Diagnosis; Early Intervention; Environment; Eye; Fiber; Fiber Optics; Functional Magnetic Resonance Imaging; General Population; Goals; Gold; Grant; Hair; Head; Image; Imaging Device; Impairment; Individual; Infant; Institutional Review Boards; Legal patent; Literature; Logistics; Loudness; Magnetic Resonance Imaging; Maps; Market Research; Methodology; Methods; Modeling; Monitor; Morphologic artifacts; Motion; Motor; Neurodevelopmental Disorder; Neurosciences; Noise; Optics; Outcome; Parents; Patients; Performance; Phase; Phenotype; Physical shape; Play; Predisposition; Prognosis; Protocols documentation; Reporting; Resolution; Rest; Role; Scalp structure; Sensory; Shapes; Signal Transduction; Small Business Technology Transfer Research; Social Development; Source; System; Technology; Toddler; Transcend; Translations; Universities; Validation; Washington; aged; autism spectrum disorder; autistic children; awake; base; cognitive capacity; commercial application; commercialization; density; design; detector; diffuse optical tomography; dyadic interaction; follow-up; functional near infrared spectroscopy; gaze; imaging system; improved; improved outcome; individuals with autism spectrum disorder; innovation; instrument; interest; neuroimaging; nonhuman primate; relating to nervous system; repetitive behavior; response; skill acquisition; skills; social; social attachment; social communication impairment; technological innovation; tomography; treatment response; treatment strategy; visual motor; visual tracking

Project Summary: EsperImage, a startup company out of Washington University (WUSTL), will develop high fidelity, wearable, optical technology that transcends limitations of both previous optical neuroimaging and magnetic resonance imaging (MRI) tools to provide naturalistic brain imaging in adults and children. A neurodevelopmental disorder affecting 1/54 children in the general population, autism spectrum disorder (ASD) presents highly heterogeneous phenotypes; however, core features are impaired development of social-communicative skills plus repetitive behaviors and restricted interests. Additionally, early difficulties with visuo-motor integration and motor imitation may be strongly associated with impairments of social communication widely reported in individuals with ASD. Because early interventions in toddlers with ASD have been proven to result in improved outcomes, innovative methods for early detection of the alterations in brain function underlying ASD prior to manifestation of behavioral symptoms are necessary to advance treatment strategies and improve prognoses. Current brain mapping methods such as functional magnetic resonance imaging (fMRI) offer promising sensitivity yet pose significant methodological challenges in studies of awake, interacting, and moving children due to the loud, constraining environment and susceptibility to motion-induced artifacts. Optical neuroimaging provides a potential surrogate for fMRI. However, image quality with traditional optical technology, functional near infrared spectroscopy (fNIRS), systems had been lacking in comparison to the gold standard of fMRI. Development of high-density diffuse optical tomography (HD-DOT), a tomographic version of fNIRS, has dramatically improved image quality, and maps sensory, motor, and cognitive networks with fidelity comparable to fMRI throughout the outer 1 cm of the cortex. Despite these advances, application of HD-DOT to naturalistic studies in children has been limited by large opto-electronic consoles and bulky fiber optics. Several wearable fiber-less fNIRS instruments are becoming available commercially, but all have multiple deficits - either lower resolution, stronger image distortions, smaller fields of view, or less signal to noise than proposed herein. This Phase-I STTR project will develop a commercialization-ready WHD-DOT device that matches performance of fiber-based HD-DOT for use in pediatric studies including on neurodevelopmental disorders. Long Term Impact: The WHD-DOT imaging systems will enable neuroscience to better understand the mechanisms of disease as well as monitor response to therapy in the developing brain. The goal of Aim 1 is to develop a robust modular scalable WHD-DOT system. The goal of Aim 2 will be to validate the WHD system in healthy adults and in children both typical developing and those with ASD. Validation will establish feasibility through mapping distributed brain activity in untethered adults and children. This will establish a full-head WHD-DOT product for commercialization development in a follow-up Phase-II proposal.

项目概要： EsperImage 是华盛顿大学 (WUSTL) 的一家初创公司，将开发高保真、可穿戴、 超越先前光学神经成像和磁共振局限性的光学技术 成像（MRI）工具为成人和儿童提供自然的脑成像。神经发育障碍 自闭症谱系障碍 (ASD) 影响总人口中 1/54 的儿童，呈现出高度异质性 表型；然而，其核心特征是社交沟通技能发展受损以及重复性行为 行为和受限制的兴趣。此外，视觉运动整合和运动模仿的早期困难 可能与广泛报道的自闭症谱系障碍患者的社交沟通障碍密切相关。 由于对自闭症谱系障碍 (ASD) 幼儿的早期干预已被证明可以改善结果，因此创新 在行为表现之前早期检测自闭症谱系障碍的脑功能改变的方法 症状对于推进治疗策略和改善预后是必要的。目前的大脑图谱 功能磁共振成像 (fMRI) 等方法提供了良好的灵敏度，但也带来了显着的影响 由于大声、限制性的影响，对清醒、互动和移动的儿童的研究面临方法论上的挑战 环境和对运动引起的伪影的敏感性。 光学神经成像为功能磁共振成像提供了潜在的替代品。然而，与传统光学相比，图像质量 与黄金相比，技术、功能近红外光谱 (fNIRS) 和系统一直缺乏 功能磁共振成像标准。开发高密度漫射光学断层扫描 (HD-DOT)，这是一种断层扫描版本 fNIRS 显着提高了图像质量，并以保真度映射感觉、运动和认知网络 与整个皮质外 1 厘米的功能磁共振成像 (fMRI) 相当。尽管取得了这些进步，HD-DOT 的应用 儿童自然主义研究受到大型光电控制台和笨重光纤的限制。一些 可穿戴式无光纤 fNIRS 仪器正在商业化，但都存在多种缺陷 - 要么 比本文提出的分辨率更低、图像失真更强、视场更小或者信噪比更小。 该第一阶段 STTR 项目将开发一款可商业化、性能匹配的 WHD-DOT 器件 基于纤维的 HD-DOT 用于儿科研究，包括神经发育障碍。长期 影响：WHD-DOT 成像系统将使神经科学能够更好地了解 疾病以及监测发育中大脑对治疗的反应。目标 1 的目标是开发一个强大的 模块化可扩展 WHD-DOT 系统。目标 2 的目标是在健康成年人和 对于典型发育儿童和患有自闭症谱系障碍 (ASD) 的儿童。验证将通过绘图确定可行性 不受束缚的成人和儿童的大脑活动分布。这将建立一个全头 WHD-DOT 产品 后续第二阶段提案中的商业化开发。