One-click Automated 3D Treatment Planning for Radiopharmaceutical Therapy

放射药物治疗(RPT)是一种替代化疗的癌症治疗方法，具有 在淋巴瘤、晚期转移性前列腺癌和 神经内分泌肿瘤。RPT的一个独特特征是可以计算出 辐射能量储存在个体患者体内的肿瘤和正常组织中。 (“剂量学”)通过成像RPT试剂在体内发射的辐射。我们知道 基于吸收剂量的针对患者的处方会导致更好的患者结果。我们的现役军人 第二阶段SBIR GRANT旨在提供RPT剂量测量的无缝集成和自动化 目前在专业知识和资源方面装备不足的临床实践 RPT的高级剂量测量。为了满足这一需求，我们正在整合我们的剂量测量算法 集成到自动化治疗计划解决方案TorchTM中，方法是添加以下附加功能 图像配准、轮廓传播和药代动力学建模。然而，我们有 发现缺少感兴趣区域(ROI)分割是 软件。为了满足这一需求，VOX正在申请补充资金，以实现以下目标 目标：(1)开发手写和基于阈值的分割工具来创建和编辑二进制 在Torch中标记正常器官和肿瘤的体积。(2)徒手验证和门限验证 分割工具，用于创建和编辑Torch中正常器官和肿瘤的二进制标签体。 将细分工具添加到Torch将帮助Vox实现第二阶段SBIR的总体目标 使RPT治疗计划更快、更准确的奖项。

Radiopharmaceutical therapy (RPT) is an alternative cancer treatment to chemotherapy that has worked well in patients with lymphoma, late-stage, metastatic prostate cancer, and neuroendocrine tumors. A unique characteristic of RPT is that it is possible to calculate how much radiation energy is deposited in tumors and normal tissues within an individual patient (“dosimetry”) by imaging the radiation emitted by the RPT agent within the body. We know that patient-specific prescriptions based on absorbed dose lead to better patient outcomes. Our active Phase 2 SBIR grant aims to provide seamless integration and automation of RPT dosimetry in clinical practices that are currently ill-equipped in terms of expertise and resources to perform advanced dosimetry for RPT. To address this need we are integrating our dosimetry algorithm into an automated treatment planning solution, TorchTM, by adding additional features such as image registration, contour propagation, and pharmacokinetic modeling. However, we have identified that a lack of region of interest (ROI) segmentation is an important feature gap in the software. To address this need, Vox is requesting supplemental funding to achieve the following aims: (1) Develop free-hand and threshold-based segmentation tools to create and edit binary label volumes for normal organs and tumors in Torch. (2) Validate free-hand and threshold-based segmentation tools to create and edit binary label volumes for normal organs and tumors in Torch. Adding segmentation tools to Torch will help Vox achieve the overall goal of the Phase II SBIR award of making RPT treatment planning faster and more accurate.