One-click Automated 3D Treatment Planning for Radiopharmaceutical Therapy

用于放射性药物治疗的一键式自动化 3D 治疗计划

基本信息

批准号：
10550358
负责人：
Joseph Grudzinski
金额：
$ 20.63万
依托单位：
VOXIMETRY, INC.
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-01 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10550358
关键词：
3-Dimensional Address Algorithms Automation Award Benchmarking Biodistribution Cancer Patient Characteristics Clinical Computer software Deposition Development Discipline of Nuclear Medicine Disseminated Malignant Neoplasm Dose Evaluation Exhibits External Beam Radiation Therapy Funding Goals Grant Hand Healthcare Systems Image Intellectual Property Label Lead Lymphoma Manuals Medical Imaging Metastatic Prostate Cancer Neoplasm Metastasis Neuroendocrine Tumors Normal tissue morphology Organ Outcome Overdose Patient-Focused Outcomes Patients Phase Physicians Physiology Radiation Radioactivity Radiopharmaceuticals Reporting Research Resources Small Business Innovation Research Grant Software Tools Step training Testing Time Treatment outcome Tumor Tissue Update Work base cancer therapy chemotherapy clinical practice cost effective digital dosimetry experience image registration individual patient individualized medicine interest neoplastic cell personalized medicine pharmacokinetic model recruit side effect software development tool treatment planning tumor verification and validation

项目摘要

Radiopharmaceutical therapy (RPT) is an alternative cancer treatment to chemotherapy that has worked well in patients with lymphoma, late-stage, metastatic prostate cancer, and neuroendocrine tumors. A unique characteristic of RPT is that it is possible to calculate how much radiation energy is deposited in tumors and normal tissues within an individual patient (“dosimetry”) by imaging the radiation emitted by the RPT agent within the body. We know that patient-specific prescriptions based on absorbed dose lead to better patient outcomes. Our active Phase 2 SBIR grant aims to provide seamless integration and automation of RPT dosimetry in clinical practices that are currently ill-equipped in terms of expertise and resources to perform advanced dosimetry for RPT. To address this need we are integrating our dosimetry algorithm into an automated treatment planning solution, TorchTM, by adding additional features such as image registration, contour propagation, and pharmacokinetic modeling. However, we have identified that a lack of region of interest (ROI) segmentation is an important feature gap in the software. To address this need, Vox is requesting supplemental funding to achieve the following aims: (1) Develop free-hand and threshold-based segmentation tools to create and edit binary label volumes for normal organs and tumors in Torch. (2) Validate free-hand and threshold-based segmentation tools to create and edit binary label volumes for normal organs and tumors in Torch. Adding segmentation tools to Torch will help Vox achieve the overall goal of the Phase II SBIR award of making RPT treatment planning faster and more accurate.

放射药物治疗（RPT）是化学疗法的替代癌症治疗在淋巴瘤，晚期，转移性前列腺癌和神经内分泌肿瘤。 RPT的独特特征是可以计算多少辐射能沉积在单个患者的肿瘤和正常组织中（“剂量法”）通过对体内RPT发出的辐射进行成像。我们知道基于吸收剂量的患者处方会导致更好的患者结局。我们活跃第2阶段SBIR Grant旨在提供无缝集成和RPT dosimetry的自动化目前在专业知识和资源方面不设置不足的临床实践 RPT的高级剂量测定。为了满足这一需求，我们正在整合剂量学算法通过添加其他功能，例如图像登记，轮廓传播和药代动力学建模。但是，我们有确定缺乏感兴趣区域（ROI）分割是重要的特征差距软件。为了满足这一需求，Vox要求补充资金以实现以下内容目的：（1）开发基于阈值和阈值的分割工具来创建和编辑二进制割炬中正常器官和肿瘤的标签体积。（2）验证基于阈值和阈值用于创建和编辑火炬正常器官和肿瘤的二进制标签量的分割工具。将细分工具添加到火炬将有助于VOX实现II期SBIR的整体目标授予更快，更准确的RPT治疗计划。