Bioanalytical, Cardiometabolic Phenotyping, Imaging and Histology Core

生物分析、心脏代谢表型、成像和组织学核心

• 批准号: 10630579
• 负责人: Barbara T Alexander
• 金额: $ 26.43万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630579
• 关键词: Basic Science; Behavioral; Biochemical; Biological Assay; Blood-Borne Pathogens; Businesses; Capital; Cardiorenal syndrome; Cardiovascular Diseases; Centers of Research Excellence; Charge; Chemistry; Clinical; Core Facility; Coupled; Data; Development; Discipline; Disease; Ensure; Enzyme-Linked Immunosorbent Assay; Equipment; Extramural Activities; Faculty; Fee-for-Service Plans; Fostering; Funding; Funding Agency; Generations; Genetic; Goals; Grant; Hazardous Chemicals; High Prevalence; Histologic; Histology; Historically Black Colleges and Universities; Human Resources; Image; Immunohistochemistry; In Vitro; Individual; Industry; Infrastructure; Institution; Kidney Diseases; Laboratories; Maintenance; Measurement; Mentors; Metabolic; Metabolic Diseases; Mississippi; Modeling; Morbidity - disease rate; Obesity; Phase; Phenotype; Physiological; Policies; Population; Postdoctoral Fellow; Procedures; Publications; Radiation; Radioimmunoassay; Recovery; Regulation; Research; Research Infrastructure; Research Methodology; Research Personnel; Resources; Safety; Scientist; Services; Standardization; Students; Supervision; System; Technical Expertise; Technology; Testing; Training; United States; United States National Institutes of Health; Universities; Update; cardiometabolism; cost; doctoral student; experience; improved; in vivo; in vivo imaging; instrumentation; member; mortality; multidisciplinary; new technology; novel strategies; pharmacologic; pre-doctoral; service utilization; success

CORE B – BIOANALYTICAL, CARDIOMETABOLIC PHENOTYPING, IMAGING AND HISTOLOGY CORE PROJECT SUMMARY/ABSTRACT The Cardiorenal and Metabolic Diseases Research Center (CMDRC) was established to enhance research infrastructure and provide mentoring to increase the ability of CMDRC investigators to successfully compete for independent NIH funding. The Bioanalytical, Cardiometabolic Phenotyping, Imaging and Histology Sub-Cores were established during Phases 1 and 2 to serve as a resource for the CMDRC, and Core B has had a transformative effect on COBRE Junior Investigators and Pilot Grant investigators, and other users of Core B. During Phase 1 and Phase 2 of COBRE support, Core B established consolidated, highly specialized services and state-of-the-art resources critical to cardiorenal and metabolic diseases researchers; technologies and services that would otherwise not be available to individual investigators. Core B is staffed by professional personnel who are not only capable of performing a variety of essential research services, but are also able to provide training and assist in the development of new research methods to meet the changing needs of COBRE investigators. Core B has multiple components that include: the Bioanalytical Sub-Core that provides centralized radioimmunoassay (RIA), ELISA, and other chemistry analyses; the Cardiometabolic Phenotyping Sub-Core that provides centrally located, state-of-the-art, highly specialized in vivo phenotypical testing to characterize physiological and behavioral parameters in genetic and pharmacological research models of obesity, cardiovascular and metabolic disease; and the Imaging and Histology Sub-Cores that provide access to state- of–the-art imaging equipment as well as histology, immunohistochemistry, and other key services. Over 88 investigators from 18 basic science and clinical departments at UMMC and 11 researchers from 8 other institutions including Jackson State University, a Historically Black Colleges and Universities (HBCUs), used Core B services and resources. Usage of Core B facilitated the generation of >260 publications and the funding of 135 extramural grants from NIH and other non-profit funding agencies. Establishment of Core B as a Fee-for Service Recharge Center initiated our Business Plan for our Model for Sustainability. The incorporation of Centralized Billing and initiation of an Online Core Management System coupled to the commitment by UMMC for continued support for capital maintenance and updates for capital equipment, and the significant increase in independent extramural funding by users of Core B that established our Research Pool will ensure long-term sustainability. Core B will continue to build upon our success so we can provide continuous support for existing infrastructure and expand Core offerings.

核心 B – 生物分析、心脏代谢表型、成像和组织学核心 项目概要/摘要 成立心肾及代谢疾病研究中心（CMDRC）以加强研究 基础设施并提供指导，以提高 CMDRC 调查员成功竞争的能力 独立的 NIH 资助。生物分析、心脏代谢表型、成像和组织学子核心 是在第一阶段和第二阶段建立的，作为 CMDRC 的资源，核心 B 拥有 对 COBRE 初级研究者和 Pilot Grant 研究者以及 Core B 的其他用户产生变革性影响。 在 COBRE 支持的第一阶段和第二阶段，核心 B 建立了整合的、高度专业化的服务 以及对心肾和代谢疾病研究人员至关重要的最先进的资源；技术和 个别调查人员无法获得的服务。 Core B配备了专业人士 不仅能够执行各种基本研究服务的人员，而且还能够 提供培训并协助开发新的研究方法，以满足 COBRE 不断变化的需求 调查人员。核心 B 具有多个组件，其中包括： 提供集中式处理的生物分析子核心 放射免疫分析 (RIA)、ELISA 和其他化学分析；心脏代谢表型分型核心 提供位于中心的、最先进的、高度专业化的体内表型测试来表征 肥胖遗传和药理学研究模型中的生理和行为参数， 心血管和代谢疾病；以及提供状态访问的成像和组织学子核心 最先进的成像设备以及组织学、免疫组织化学和其他关键服务。 88岁以上 来自 UMMC 18 个基础科学和临床部门的研究人员以及来自其他 8 个部门的 11 名研究人员 包括杰克逊州立大学在内的一所历史悠久的黑人学院和大学 (HBCU) 等机构使用 核心 B 服务和资源。核心 B 的使用促进了超过 260 种出版物的产生和资助 来自 NIH 和其他非营利资助机构的 135 项校外资助。建立核心B作为收费 服务充值中心启动了可持续发展模式的业务计划。纳入 集中计费和启动在线核心管理系统以及 UMMC 的承诺 持续支持资本维护和资本设备更新，以及显着增加 建立我们研究池的核心 B 用户的独立外部资助将确保长期 可持续性。核心 B 将继续在我们的成功基础上继续发展，以便我们能够为现有的 基础设施并扩展核心产品。