Bioanalytical, Cardiometabolic Phenotyping, Imaging and Histology Core

生物分析、心脏代谢表型、成像和组织学核心

• 批准号: 10630579
• 负责人: Barbara T Alexander
• 金额: $ 26.43万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630579
• 关键词: Basic Science; Behavioral; Biochemical; Biological Assay; Blood-Borne Pathogens; Businesses; Capital; Cardiorenal syndrome; Cardiovascular Diseases; Centers of Research Excellence; Charge; Chemistry; Clinical; Core Facility; Coupled; Data; Development; Discipline; Disease; Ensure; Enzyme-Linked Immunosorbent Assay; Equipment; Extramural Activities; Faculty; Fee-for-Service Plans; Fostering; Funding; Funding Agency; Generations; Genetic; Goals; Grant; Hazardous Chemicals; High Prevalence; Histologic; Histology; Historically Black Colleges and Universities; Human Resources; Image; Immunohistochemistry; In Vitro; Individual; Industry; Infrastructure; Institution; Kidney Diseases; Laboratories; Maintenance; Measurement; Mentors; Metabolic; Metabolic Diseases; Mississippi; Modeling; Morbidity - disease rate; Obesity; Phase; Phenotype; Physiological; Policies; Population; Postdoctoral Fellow; Procedures; Publications; Radiation; Radioimmunoassay; Recovery; Regulation; Research; Research Infrastructure; Research Methodology; Research Personnel; Resources; Safety; Scientist; Services; Standardization; Students; Supervision; System; Technical Expertise; Technology; Testing; Training; United States; United States National Institutes of Health; Universities; Update; cardiometabolism; cost; doctoral student; experience; improved; in vivo; in vivo imaging; instrumentation; member; mortality; multidisciplinary; new technology; novel strategies; pharmacologic; pre-doctoral; service utilization; success

CORE B – BIOANALYTICAL, CARDIOMETABOLIC PHENOTYPING, IMAGING AND HISTOLOGY CORE PROJECT SUMMARY/ABSTRACT The Cardiorenal and Metabolic Diseases Research Center (CMDRC) was established to enhance research infrastructure and provide mentoring to increase the ability of CMDRC investigators to successfully compete for independent NIH funding. The Bioanalytical, Cardiometabolic Phenotyping, Imaging and Histology Sub-Cores were established during Phases 1 and 2 to serve as a resource for the CMDRC, and Core B has had a transformative effect on COBRE Junior Investigators and Pilot Grant investigators, and other users of Core B. During Phase 1 and Phase 2 of COBRE support, Core B established consolidated, highly specialized services and state-of-the-art resources critical to cardiorenal and metabolic diseases researchers; technologies and services that would otherwise not be available to individual investigators. Core B is staffed by professional personnel who are not only capable of performing a variety of essential research services, but are also able to provide training and assist in the development of new research methods to meet the changing needs of COBRE investigators. Core B has multiple components that include: the Bioanalytical Sub-Core that provides centralized radioimmunoassay (RIA), ELISA, and other chemistry analyses; the Cardiometabolic Phenotyping Sub-Core that provides centrally located, state-of-the-art, highly specialized in vivo phenotypical testing to characterize physiological and behavioral parameters in genetic and pharmacological research models of obesity, cardiovascular and metabolic disease; and the Imaging and Histology Sub-Cores that provide access to state- of–the-art imaging equipment as well as histology, immunohistochemistry, and other key services. Over 88 investigators from 18 basic science and clinical departments at UMMC and 11 researchers from 8 other institutions including Jackson State University, a Historically Black Colleges and Universities (HBCUs), used Core B services and resources. Usage of Core B facilitated the generation of >260 publications and the funding of 135 extramural grants from NIH and other non-profit funding agencies. Establishment of Core B as a Fee-for Service Recharge Center initiated our Business Plan for our Model for Sustainability. The incorporation of Centralized Billing and initiation of an Online Core Management System coupled to the commitment by UMMC for continued support for capital maintenance and updates for capital equipment, and the significant increase in independent extramural funding by users of Core B that established our Research Pool will ensure long-term sustainability. Core B will continue to build upon our success so we can provide continuous support for existing infrastructure and expand Core offerings.

核心B -生物分析、心脏代谢表型、成像和组织学核心 项目总结/摘要 建立了肾脏和代谢疾病研究中心（CMDRC），以加强研究 基础设施，并提供指导，以提高CMDRC调查人员成功竞争 独立的NIH资助。生物分析、心脏代谢表型、成像和组织学子核心 在第1和第2阶段期间建立，作为CMDRC的资源，而核心B已经 对COBRE初级研究者和试点补助金研究者以及核心B的其他用户产生了变革性影响。 在COBRE支持的第1阶段和第2阶段，Core B建立了统一的、高度专业化的服务 以及对心肾和代谢疾病研究人员至关重要的最先进的资源;技术和 调查人员个人本来无法获得的服务。核心B由专业人员 人员谁不仅能够执行各种基本的研究服务，但也能够 提供培训并协助开发新的研究方法，以满足COBRE不断变化的需求 investigators.核心B有多个组件，包括：生物分析子核心，提供集中的 放射免疫测定（RIA）、ELISA和其他化学分析;心脏代谢表型分型子核心， 提供位于中心的、最先进的、高度专业化的体内表型检测， 肥胖症的遗传和药理学研究模型中的生理和行为参数， 心血管和代谢疾病;以及成像和组织学子核心，提供访问状态- 最先进的成像设备以及组织学、免疫组织化学和其他关键服务。超过88 来自UMMC 18个基础科学和临床部门的研究人员和来自其他8个部门的11名研究人员 机构，包括杰克逊州立大学，历史上黑人学院和大学（HBCUs），使用 核心B服务和资源。核心B的使用促进了超过260种出版物的产生和资金的筹措 来自NIH和其他非营利资助机构的135项校外赠款。建立核心B作为收费 服务充值中心启动了我们的可持续发展模式的业务计划。掺入 集中计费和启动在线核心管理系统，与UMMC的承诺相结合 继续支持资本维护和资本设备更新，以及 由核心B的用户建立我们的研究池的独立校外资金将确保长期 持续发展核心B将继续巩固我们的成功，以便我们能够为现有的 基础设施和扩展核心产品。