Core B - Bioanalytical, Mass Spectroscopy, Imaging and Histology Core

核心 B - 生物分析、质谱、成像和组织学核心

• 批准号: 10403630
• 负责人: Barbara T Alexander
• 金额: $ 58.71万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-05 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10403630
• 关键词: Applications Grants; Basic Science; Biochemical; Biological Assay; Blood-Borne Pathogens; Businesses; Cardiovascular Diseases; Centers of Research Excellence; Chemicals; Chemistry; Clinical; Core Facility; Data; Data Analyses; Development; Discipline; Disease; Ensure; Enzyme-Linked Immunosorbent Assay; Equipment; Extramural Activities; Faculty; Fostering; Funding; Funding Agency; Generations; Goals; Grant; Hazardous Chemicals; High Pressure Liquid Chromatography; High Prevalence; Histologic; Histology; Historically Black Colleges and Universities; Human Resources; Image; Immunohistochemistry; In Situ Hybridization; In Vitro; Individual; Infrastructure; Institution; Kidney Diseases; Laboratories; Maintenance; Mass Spectrum Analysis; Mentors; Metabolic; Metabolic Diseases; Mississippi; Morbidity - disease rate; Phase; Population; Procedures; Proteomics; Publications; Radiation; Radioimmunoassay; Recovery; Regulation; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resources; Safety; Scientist; Services; Source; Standardization; Students; Supervision; System; Technical Expertise; Technology; Three-Dimensional Image; Tissue Embedding; Tissues; Training; United States; United States National Institutes of Health; Universities; Update; complement resource; cost; cryostat; experience; imaging capabilities; imaging platform; in vivo imaging; instrumentation; lipidomics; liquid chromatography mass spectrometry; member; mortality; multidisciplinary; new technology; novel strategies; preclinical imaging; programs; success

CORE B – BIOANALYTICAL, MASS SPECTROSCOPY, IMAGING AND HISTOLOGY CORE PROJECT SUMMARY/ABSTRACT The Cardiorenal and Metabolic Diseases Research Center (CMDRC) was established to enhance research infrastructure and provide mentoring to increase the ability of COBRE investigators to successfully compete for independent NIH funding. The Bioanalytical, Mass Spectroscopy, Imaging and Histology Core B was established as a resource for the CMDRC during Phase I, and this core has had a transformative effect on COBRE junior investigators, Pilot Grant investigators, and investigators from local Historically Black Colleges and Universities (HBCUs). During Phase I of COBRE support, Core B established services critical to cardiorenal and metabolic diseases researchers in addition to numerous investigators who collaborate with members of the CMDRC. Core B provides access to technologies and services that would otherwise not be available in Mississippi. This includes consolidated, highly specialized services and state-of-the-art resources staffed by professional personnel who are not only capable of performing a variety of essential research services, but are also able to provide training and assist in the development of new research methods to meet the changing needs of COBRE investigators. Core B has multiple components including the Bioanalytical/Mass Spec Sub-Cores that provide centralized radioimmunoassay (RIA), ELISA, HPLC, LC/Mass spectroscopy, proteomics, lipidomics and other biochemical/chemistry analyses, and the Histology/Imaging Sub-Cores that provide access to state-of–the-art imaging equipment as well as histology, immunohistochemistry, and other key services. Faculty from over 15 different basic science and clinical departments at UMMC in addition to researchers from other institutions including Jackson State University, a HBCU, used services and resources provided by Core B during Phase I of COBRE support. Resources and services provided by Core B were substantially expanded during Phase I and this was supported by the addition of new state-of-the-art equipment to each Sub-Core. Usage of Core B by investigators facilitated the generation of >250 publications and provided direct support for the receipt of many extramural funded grants from NIH and other non-profit funding agencies. Establishment of Sub-Cores as Recharge Centers initiated our business plan for sustainability and Core B will continue to build upon our success so that we can provide continuous support for existing infrastructure, resources and services, and expand Core offerings to meet the needs of cardiorenal and metabolic disease researchers at UMMC.

核心B -生物分析、质谱、成像和组织学核心 项目总结/摘要 建立了肾脏和代谢疾病研究中心（CMDRC），以加强研究 基础设施，并提供指导，以提高COBRE调查人员成功竞争 独立的NIH资助。生物分析、质谱、成像和组织学核心B是 作为CMDRC在第一阶段的资源，这一核心对 COBRE初级调查员、试点补助金调查员和当地历史黑人学院的调查员 大学（HBCU）。在COBRE支持的第一阶段，核心B建立了关键服务， 心肾和代谢疾病的研究人员，除了许多研究人员谁合作， CMDRC的成员。核心B提供了获得技术和服务的机会，否则这些技术和服务将无法获得。 在密西西比有售。这包括高度专业化的综合服务和最先进的资源 由专业人员组成，他们不仅能够进行各种必要的研究， 服务，但也能够提供培训，并协助开发新的研究方法，以满足 COBRE调查人员不断变化的需求。核心B具有多个组件，包括生物分析/质谱 提供集中式放射免疫分析（RIA）、ELISA、HPLC、LC/质谱分析的规范子核心， 蛋白质组学、脂质组学和其他生化/化学分析，以及组织学/成像子核心， 提供最先进的成像设备以及组织学，免疫组织化学和其他 关键服务。来自UMMC超过15个不同基础科学和临床部门的教师， 来自其他机构的研究人员，包括杰克逊州立大学，HBCU，使用的服务和资源 由核心B在COBRE支持的第一阶段提供。核心B提供的资源和服务包括 在第一阶段大幅扩大，这是通过增加新的最先进的支持 每个子核心的设备。研究者使用核心B有助于生成>250篇出版物 并为获得NIH和其他非营利组织的许多校外赠款提供直接支持 供资机构。建立子核心作为充电中心启动了我们的业务计划， 可持续发展和核心B将继续建立在我们的成功，使我们能够提供持续的支持， 现有的基础设施、资源和服务，并扩展核心产品，以满足心肾 和代谢疾病研究人员。