Core B - Bioanalytical, Mass Spectroscopy, Imaging and Histology Core

核心 B - 生物分析、质谱、成像和组织学核心

• 批准号: 10159919
• 负责人: Barbara T Alexander
• 金额: $ 58.71万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-05 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159919
• 关键词: Applications Grants; Basic Science; Biochemical; Biological Assay; Blood-Borne Pathogens; Businesses; Cardiovascular Diseases; Centers of Research Excellence; Chemicals; Chemistry; Clinical; Core Facility; Data; Data Analyses; Development; Discipline; Disease; Ensure; Enzyme-Linked Immunosorbent Assay; Enzymes; Equipment; Extramural Activities; Faculty; Fostering; Funding; Funding Agency; Generations; Goals; Grant; Hazardous Chemicals; High Pressure Liquid Chromatography; High Prevalence; Histologic; Histology; Historically Black Colleges and Universities; Human Resources; Image; Immunoassay; Immunohistochemistry; In Situ Hybridization; In Vitro; Individual; Infrastructure; Institution; Kidney Diseases; Laboratories; Link; Maintenance; Mass Spectrum Analysis; Mentors; Metabolic; Metabolic Diseases; Mississippi; Morbidity - disease rate; Phase; Population; Procedures; Proteomics; Publications; Radiation; Radioimmunoassay; Recovery; Regulation; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resources; Safety; Scientist; Services; Source; Standardization; Students; Supervision; System; Technical Expertise; Technology; Three-Dimensional Image; Tissue Embedding; Tissues; Training; United States; United States National Institutes of Health; Universities; Update; complement resource; cost; cryostat; experience; imaging capabilities; imaging platform; in vivo imaging; instrumentation; lipidomics; liquid chromatography mass spectrometry; member; mortality; multidisciplinary; new technology; novel strategies; preclinical imaging; programs; success

CORE B – BIOANALYTICAL, MASS SPECTROSCOPY, IMAGING AND HISTOLOGY CORE PROJECT SUMMARY/ABSTRACT The Cardiorenal and Metabolic Diseases Research Center (CMDRC) was established to enhance research infrastructure and provide mentoring to increase the ability of COBRE investigators to successfully compete for independent NIH funding. The Bioanalytical, Mass Spectroscopy, Imaging and Histology Core B was established as a resource for the CMDRC during Phase I, and this core has had a transformative effect on COBRE junior investigators, Pilot Grant investigators, and investigators from local Historically Black Colleges and Universities (HBCUs). During Phase I of COBRE support, Core B established services critical to cardiorenal and metabolic diseases researchers in addition to numerous investigators who collaborate with members of the CMDRC. Core B provides access to technologies and services that would otherwise not be available in Mississippi. This includes consolidated, highly specialized services and state-of-the-art resources staffed by professional personnel who are not only capable of performing a variety of essential research services, but are also able to provide training and assist in the development of new research methods to meet the changing needs of COBRE investigators. Core B has multiple components including the Bioanalytical/Mass Spec Sub-Cores that provide centralized radioimmunoassay (RIA), ELISA, HPLC, LC/Mass spectroscopy, proteomics, lipidomics and other biochemical/chemistry analyses, and the Histology/Imaging Sub-Cores that provide access to state-of–the-art imaging equipment as well as histology, immunohistochemistry, and other key services. Faculty from over 15 different basic science and clinical departments at UMMC in addition to researchers from other institutions including Jackson State University, a HBCU, used services and resources provided by Core B during Phase I of COBRE support. Resources and services provided by Core B were substantially expanded during Phase I and this was supported by the addition of new state-of-the-art equipment to each Sub-Core. Usage of Core B by investigators facilitated the generation of >250 publications and provided direct support for the receipt of many extramural funded grants from NIH and other non-profit funding agencies. Establishment of Sub-Cores as Recharge Centers initiated our business plan for sustainability and Core B will continue to build upon our success so that we can provide continuous support for existing infrastructure, resources and services, and expand Core offerings to meet the needs of cardiorenal and metabolic disease researchers at UMMC.

核心B - 生物分析，质谱，成像和组织学核心 项目摘要/摘要 建立了心脏和代谢性疾病研究中心（CMDRC），以增强研究 基础架构并提供心理，以提高山核桃研究人员成功竞争的能力 独立的NIH资金。生物分析，质谱，成像和组织学核心B为 在第一阶段作为CMDRC的资源建立，该核心对 柯布尔初级调查人员，试点赠款调查人员和当地历史悠久的黑人学院的调查员 和大学（HBCUS）。在COBRE支持的第一阶段，核心B建立的服务至关重要 除了众多与之合作的研究人员之外，心脏和代谢疾病研究人员 CMDRC的成员。核心B提供了对否则不会是的技术和服务的访问 可在密西西比州购买。这包括合并，高度专业的服务和最先进的资源 由专业人员组成，他们不仅有能力进行各种基本研究 服务，但也能够提供培训并协助开发新的研究方法以满足 毛绒调查员的需求不断变化。 Core B具有多个组件，包括生物分析/质量 提供集中放射免疫分析（RIA），ELISA，HPLC，LC/质谱的SPEC子核， 蛋白质组学，脂质组学和其他生化/化学分析以及组织学/成像子核 提供最先进的成像设备以及组织学，免疫组织化学以及其他访问 关键服务。 UMMC的15多个不同基础科学和临床部门的教师 来自其他机构的研究人员，包括杰克逊州立大学，HBCU，使用的服务和资源 由Core B提供的核心支持期间。核心提供的资源和服务是 在第一阶段大大扩展了，这得到了新的最先进的支持 每个子核心的设备。调查人员使用核心B的使用准备了> 250个出版物的生成 并为收到来自NIH和其他非营利组织的许多外部资助的赠款提供了直接支持 资金机构。建立子核作为充值中心启动了我们的业务计划 可持续性和核心B将继续以我们的成功为基础，以便我们可以为 现有的基础设施，资源和服务，并扩展核心产品以满足心脏的需求 以及UMMC的代谢疾病研究人员。